Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Zhuozhuang Lu"'
Autor:
Zhichao Zhang, Xiaojuan Guo, Wenzhe Hou, Xiaohui Zou, Yongjin Wang, Shuqing Liu, Zhuozhuang Lu
Publikováno v:
Viruses, Vol 16, Iss 5, p 761 (2024)
Mouse adenoviruses (MAdV) play important roles in studying host–adenovirus interaction. However, easy-to-use reverse genetics systems are still lacking for MAdV. An infectious plasmid pKRMAV1 was constructed by ligating genomic DNA of wild-type MAd
Externí odkaz:
https://doaj.org/article/4e8dde3fbfd74996bb5420da01bd893e
Publikováno v:
Genes, Vol 15, Iss 4, p 467 (2024)
The variable domain of a heavy-chain antibody (VHH) has the potential to be used to redirect the cell tropism of adenoviral vectors. Here, we attempted to establish platforms to simplify the screening of VHHs for their specific targeting function whe
Externí odkaz:
https://doaj.org/article/b9622f5b89ce4a24b29bbdf2eb210b75
Autor:
Matvey V. Sprindzhuk, Aleksandr S. Vladyko, Zhuozhuang Lu, Leonid P. Titov, Vasiliy I. Bernik
Publikováno v:
Измерение, мониторинг, управление, контроль, Iss 3 (2023)
Background. The coronavirus epidemic continues, but there is evidence that the society has already mastered effective measures for the prevention and treatment of this disease. The unresolved problems are prevention, early diagnosis and timely treatm
Externí odkaz:
https://doaj.org/article/ab300e7b913549bea9559ef4c4909431
Autor:
Juan Chen, Xiaojuan Guo, Xiaohui Zou, Min Wang, Chunlei Yang, Wenzhe Hou, Matvey V. Sprindzuk, Zhuozhuang Lu
Publikováno v:
Viruses, Vol 16, Iss 4, p 550 (2024)
The administration route affects the biodistribution of a gene transfer vector and the expression of a transgene. A simian adenovirus 1 vector carrying firefly luciferase and GFP reporter genes (SAdV1-GFluc) were constructed, and its biodistribution
Externí odkaz:
https://doaj.org/article/52c89e0c306c4f77945db13190192fda
Autor:
Xinglong Liu, Xiaohui Zou, Wenfeng Zhang, Xiaojuan Guo, Min Wang, Yingtao Lv, Tao Hung, Zhuozhuang Lu
Publikováno v:
Microbiology Spectrum, Vol 10, Iss 3 (2022)
ABSTRACT Essential genus-specific genes have not been discovered for fowl adenovirus (FAdV), which hampers the development of FAdV-based vectors and attenuated FAdV vaccines. Reverse genetics approaches were employed to construct FAdV-4 mutants carry
Externí odkaz:
https://doaj.org/article/6cf34e573ae043e5acf40d74f09d0942
Publikováno v:
Viruses, Vol 15, Iss 2, p 529 (2023)
The transcriptome of fowl adenovirus has not been comprehensively revealed. Here, we attempted to analyze the fowl adenovirus 4 (FAdV-4) transcriptome by deep sequencing. RNA samples were extracted from chicken LMH cells at 12, 18 or 26 h post-FAdV-4
Externí odkaz:
https://doaj.org/article/590013003bcd4c0da4ed1f1e02003cd1
Publikováno v:
Genes, Vol 13, Iss 12, p 2316 (2022)
Fowl adenovirus 4 (FAdV-4) has the potential to be constructed as a gene transfer vector for human gene therapy or vaccine development to avoid the pre-existing immunity to human adenoviruses. To enhance the transduction of FAdV-4 to human cells, CEL
Externí odkaz:
https://doaj.org/article/d86c5ed79d5e44e1bc0d7ce53cb0c720
Autor:
Xiaojuan Guo, Yangyang Sun, Juan Chen, Xiaohui Zou, Wenzhe Hou, Wenjie Tan, Tao Hung, Zhuozhuang Lu
Publikováno v:
Viruses, Vol 14, Iss 3, p 546 (2022)
Gene therapy and vaccine development need more novel adenovirus vectors. Here, we attempt to provide strategies to construct adenovirus vectors based on restriction-assembly for researchers with little experience in this field. Restriction-assembly i
Externí odkaz:
https://doaj.org/article/40e31cbe0cf042e5a4bc023003f2e631
Autor:
Bingyu Yan, Xiaohui Zou, Xinglong Liu, Jiaming Zhao, Wenfeng Zhang, Xiaojuan Guo, Min Wang, Yingtao Lv, Zhuozhuang Lu
Publikováno v:
Viruses, Vol 12, Iss 3, p 301 (2020)
A novel fowl adenovirus 4 (FAdV-4) has caused significant economic losses to the poultry industry in China since 2015. We established an easy-to-use reverse genetics system for modification of the whole right and partial left ends of the novel FAdV-4
Externí odkaz:
https://doaj.org/article/06d5f55f1b944d829e6ac279c54e8f5a
Autor:
Jiaming Lan, Yao Deng, Hong Chen, Guangwen Lu, Wen Wang, Xiaojuan Guo, Zhuozhuang Lu, George F Gao, Wenjie Tan
Publikováno v:
PLoS ONE, Vol 9, Iss 11, p e112602 (2014)
The development of an effective vaccine is critical for prevention of a Middle East respiratory syndrome coronavirus (MERS-CoV) pandemic. Some studies have indicated the receptor-binding domain (RBD) protein of MERS-CoV spike (S) is a good candidate
Externí odkaz:
https://doaj.org/article/f0246ad6df0c4c40a1c08a856267f714