Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Zhuoxun Wu"'
Autor:
Lei Zhang, Yidong Li, Qianchao Wang, Zhuo Chen, Xiaoyun Li, Zhuoxun Wu, Chaohua Hu, Dan Liao, Wei Zhang, Zhe-Sheng Chen
Publikováno v:
Molecular Cancer, Vol 19, Iss 1, Pp 1-18 (2020)
Abstract Background PI3K/AKT is a vital signaling pathway in humans. Recently, several PI3K/AKT inhibitors were reported to have the ability to reverse cancer multidrug resistance (MDR); however, specific targets in the PI3K/AKT pathways and the mech
Externí odkaz:
https://doaj.org/article/950f8b4c745b48e8a7162241b04d0384
ABCB1 limits the cytotoxic activity of TAK-243, an inhibitor of the ubiquitin-activating enzyme UBA1
Autor:
Zhuoxun Wu, Yuqi Yang, Zining Lei, Silpa Narayanan, Jingquan Wang, Qiuxu Teng, Megumi Murakami, Suresh V. Ambudkar, Fengfeng Ping, Zhesheng Chen
Publikováno v:
Frontiers in Bioscience-Landmark, Vol 27, Iss 1, p 005 (2022)
Background: One of the major concerns of cancer therapy is the emergence of multidrug resistance (MDR). The MDR-associated ATP-binding cassette sub-family B member 1 (ABCB1) transporter is established to mediate resistance against numerous anticancer
Externí odkaz:
https://doaj.org/article/b7b1f87232c0400688827ff7e6f9b2fb
ABCB1 limits the cytotoxic activity of TAK-243, an inhibitor of the ubiquitin-activating enzyme UBA1
Autor:
Zhesheng Chen, Fengfeng Ping, Suresh V. Ambudkar, Megumi Murakami, Qiuxu Teng, Jingquan Wang, Silpa Narayanan, Zining Lei, Yuqi Yang, Zhuoxun Wu
Publikováno v:
Front Biosci (Landmark Ed)
BACKGROUND: One of the major concerns of cancer therapy is the emergence of multidrug resistance (MDR). The MDR-associated ATP-binding cassette sub-family B member 1 (ABCB1) transporter is established to mediate resistance against numerous anticancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d0253bab88963d2ffe739e0502c0290
https://europepmc.org/articles/PMC10258814/
https://europepmc.org/articles/PMC10258814/
Autor:
Zhuoxun Wu, Qiu-Xu Teng, Yuqi Yang, Nikita Acharekar, Jing-Quan Wang, Min He, Sabesan Yoganathan, Jun Lin, Jian Wang, Zhe-Sheng Chen
Publikováno v:
Cancer Research. 82:409-409
ABCG2/BCRP transporter-mediated Multidrug resistance (MDR) in cancers has been considered as one of the obstacles to the cancer chemotherapy. Our recent study characterized the MET inhibitor tepotinib as a potent ABCB1 inhibitor. In the present study
Autor:
Zhang, Lei, Yidong Li, Qianchao Wang, Chen, Zhuo, Xiaoyun Li, Zhuoxun Wu, Chaohua Hu, Liao, Dan, Zhang, Wei, Zhe-Sheng Chen
Additional file 5: Figure S5 JC-1 analysis of the apoptosis of KB-C2 and H460/MX80 cells and the derivative cells with deficiency of P110β. JC-1 staining indicating mitochondrial membrane potential showed severe depolarization of the mitochondrial m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a2351cb9e5f20b2f86dcb299e64ce5c
Autor:
Zhang, Lei, Yidong Li, Qianchao Wang, Chen, Zhuo, Xiaoyun Li, Zhuoxun Wu, Chaohua Hu, Liao, Dan, Zhang, Wei, Zhe-Sheng Chen
Additional file 2: Figure S2 Activity of BAY-1082439 to alter the efflux property of P-gp and BCRP transporters in the MDR cancer cells. (A) ATPase variance of P-gp and BCRP at different concentrations of BAY-1082439. The curves corresponding to non-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6a0bc38059d24ebf855dccdbe58da153
Autor:
Zhang, Lei, Yidong Li, Qianchao Wang, Chen, Zhuo, Xiaoyun Li, Zhuoxun Wu, Chaohua Hu, Liao, Dan, Zhang, Wei, Zhe-Sheng Chen
Additional file 2: Figure S2 Activity of BAY-1082439 to alter the efflux property of P-gp and BCRP transporters in the MDR cancer cells. (A) ATPase variance of P-gp and BCRP at different concentrations of BAY-1082439. The curves corresponding to non-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f8a7babdfce50dfb056225fd83ca164f
Autor:
Zhang, Lei, Yidong Li, Qianchao Wang, Chen, Zhuo, Xiaoyun Li, Zhuoxun Wu, Chaohua Hu, Liao, Dan, Zhang, Wei, Zhe-Sheng Chen
Additional file 3: Figure S3 Long-term influence of BAY-1082439 on the accumulation of doxorubicin within the MDR and drug-sensitive cell lines. (A) BAY-1082439 induced higher ratios of MDR KB-C2 and H460/MX80 cells with a weakened ability to efflux
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::40f9341c421e0535fb0b968ea0686bb7
Autor:
Zhang, Lei, Yidong Li, Qianchao Wang, Chen, Zhuo, Xiaoyun Li, Zhuoxun Wu, Chaohua Hu, Liao, Dan, Zhang, Wei, Zhe-Sheng Chen
Additional file 3: Figure S3 Long-term influence of BAY-1082439 on the accumulation of doxorubicin within the MDR and drug-sensitive cell lines. (A) BAY-1082439 induced higher ratios of MDR KB-C2 and H460/MX80 cells with a weakened ability to efflux
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f4de43baa61ba241fc28646845be593d
Autor:
Zhang, Lei, Yidong Li, Qianchao Wang, Chen, Zhuo, Xiaoyun Li, Zhuoxun Wu, Chaohua Hu, Liao, Dan, Zhang, Wei, Zhe-Sheng Chen
Additional file 4: Figure S4 Immunofluorescent microscopy showing target knockout of P110 subunits. Knockout of target P110 subunit (P110α/PIK3CA or P110β/PIK3CB) in the objective cell populations showed absence of the fluorescent signals that indi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5a77ca4ebd9e145e3573a4aa67b62ee3