Interplay of m6A and histone modifications contributes to temozolomide resistance in glioblastoma

Autor: Fuxi Li, Siyun Chen, Jiaming Yu, Zhuoxing Gao, Zhangyi Sun, Yang Yi, Teng Long, Chuanxia Zhang, Yuzhe Li, Yimin Pan, Chaoying Qin, Wenyong Long, Qing Liu, Wei Zhao

Publikováno v: Clinical and Translational Medicine, Vol 11, Iss 9, Pp n/a-n/a (2021)

Abstract Background Despite the development of new treatment protocols for glioblastoma (GBM), temozolomide (TMZ) resistance remains a primary hindrance. Previous studies, including our study, have shown that aberrant N6‐methyladenosine (m6A) modif

Externí odkaz: https://doaj.org/article/7854cee962c142b590ebd42800c8d82d

Figure S1-S6,Table S1,Supplementary Methods from Epigenetic Profiling Identifies LIF as a Super-enhancer-Controlled Regulator of Stem Cell–like Properties in Osteosarcoma

Autor: Wei Zhao, Changye Zou, Guohao Lu, Zhuoxing Gao, Jiayan Yang, Zhenguo Liu, Li Wang, Jincan He, Yangyang He, Bing Lu

Supplementary Figure 1. Super-enhancers (SEs) in osteosarcoma cells. Related to Figure 1. Supplementary Figure 2. LIF promotes epithelial-mesenchymal transition (EMT) gene expression. Related to Figure 2. Supplementary Figure 3. GSK-J4 inhibits stem

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1844ada275bfd540abfe3e5472be2e66
https://doi.org/10.1158/1541-7786.22512982.v1

Epigenetic Profiling Identifies LIF as a Super-enhancer-Controlled Regulator of Stem Cell–like Properties in Osteosarcoma

Autor: Li Wang, Guohao Lu, Zhuoxing Gao, Jiayan Yang, Bing Lu, Zhenguo Liu, Jincan He, Changye Zou, Wei Zhao, Yangyang He

Publikováno v: Molecular Cancer Research. 18:57-67

Osteosarcoma is an aggressive malignancy with poor prognosis. Super-enhancers (SE) have been highlighted as critical oncogenic elements required for maintaining the cancer cell characteristics. However, the regulatory role of SEs in osteosarcoma prop

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8441aa219f83b54bc8072225b6c3fe2d
https://doi.org/10.1158/1541-7786.mcr-19-0470

Targeting Super‐Enhancers via Nanoparticle‐Facilitated BRD4 and CDK7 Inhibitors Synergistically Suppresses Pancreatic Ductal Adenocarcinoma

Autor: Xinru You, Zhuoxing Gao, Xiao-Yu Yin, Qiong-Cong Xu, Chunlei Dai, Jun Wu, Xi-Tai Huang, Fuxi Li, Shi-Jin Li, Wei Zhao, Jie-Qin Wang, Li Wang, Chen-Song Huang

Publikováno v: Advanced Science, Vol 7, Iss 7, Pp n/a-n/a (2020)
Advanced Science

Pancreatic ductal adenocarcinoma (PDAC) is a lethal malignant cancer with complex genomic variations, and no targetable genomic lesions have been found yet. Super‐enhancers (SEs) have been found to contribute to the continuous and robust oncogenic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc54790d6cdc69a1351a93e6d4e83b44
https://doaj.org/article/75cfbdf60b16442eaa694c781357745f

Interplay of m⁶A and histone modifications contributes to temozolomide resistance in glioblastoma.

Autor: Li, Fuxi^1,2,3 (AUTHOR), Chen, Siyun³ (AUTHOR), Yu, Jiaming³ (AUTHOR), Gao, Zhuoxing² (AUTHOR), Sun, Zhangyi³ (AUTHOR), Yi, Yang³ (AUTHOR), Long, Teng³ (AUTHOR), Zhang, Chuanxia² (AUTHOR), Li, Yuzhe⁴ (AUTHOR), Pan, Yimin⁴ (AUTHOR), Qin, Chaoying⁴ (AUTHOR), Long, Wenyong⁴ (AUTHOR) wylongdr@csu.edu.cn, Liu, Qing⁴ (AUTHOR) liuqingdr@csu.edu.cn, Zhao, Wei² (AUTHOR) zhaowei23@mail.sysu.edu.cn

Publikováno v: Clinical & Translational Medicine. Sep2021, Vol. 11 Issue 9, p1-19. 19p.