Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Zhuoliang Chen"'
Autor:
Upendra Argikar, Markus Blatter, Dallas Bednarczyk, Zhuoliang Chen, Young Shin Cho, Michaël Doré, Jennifer L. Dumouchel, Samuel Ho, Klemens Hoegenauer, Toshio Kawanami, Simon Mathieu, Erik Meredith, Henrik Möbitz, Stephen K. Murphy, Saravanan Parthasarathy, Carole Pissot Soldermann, Jobette Santos, Serena Silver, Suzanne Skolnik, Aleksandar Stojanovic
Publikováno v:
Journal of medicinal chemistry. 65(18)
An imidazolone → triazolone replacement addressed the limited passive permeability of a series of protein arginine methyl transferase 5 (PRMT5) inhibitors. This increase in passive permeability was unexpected given the increase in the hydrogen bond
Autor:
Subarna Shakya, José S. Duca, Elizabeth R. Sprague, Xin Chen, Zhuoliang Chen, Carol Joud, Yaping Wang, John William Giraldes, Wenlin Shao, Simon Mathieu, Chen Christine Hiu-Tung, Yanqiu Yuan, Kristen Hurov, B. Barry Touré, Christopher Sean Straub
Publikováno v:
Journal of Medicinal Chemistry. 60:2155-2161
While adding the structural features that are more favored by on-target activity is the more common strategy in selectivity optimization, the opposite strategy of subtracting the structural features that contribute more to off-target activity can als
Autor:
Yaping Wang, Xin Chen, Zhuoliang Chen, John William Giraldes, Kirk Wright, Sean Kim, José S. Duca, Eric J. Martin, J. Tres Brazell, Kristen Hurov, Elizabeth R. Sprague, Yun Feng, David E. Puleo, Subarna Shakya, Yanqiu Yuan, David Sage, Matthew J. Meyer, Yuji Mishina, Yan Yan-Neale, Christopher Sean Straub, Li Tian, Simon Mathieu, Dongshu Chen, Wenlin Shao, B. Barry Touré, Troy Smith
Publikováno v:
Journal of Medicinal Chemistry. 59:4711-4723
MELK kinase has been implicated in playing an important role in tumorigenesis. Our previous studies suggested that MELK is involved in the regulation of cell cycle and its genetic depletion leads to growth inhibition in a subset of high MELK-expressi
Autor:
Oljan Repic, Joseph Mckenna, Song Xue, Zhuoliang Chen, Run-Ming Wang, Kapa Prasad, Wen-Chung Shieh
Publikováno v:
Tetrahedron Letters. 49:5359-5362
Our study demonstrated that 4-(4,6-dimethoxy-1,3,5-triazine-2-yl)-4-methyl-morpholinium chloride (DMTMM) is a versatile coupling reagent for the synthesis of sterically-hindered peptidomimetics. It is superior to HBTU/HOBt and CDMT in controlling rac
Autor:
Kavitha Venkatesan, Jaison Jacob, Shumei Liu, Fei Feng, Brandon Antonakos, Zhao B. Kang, Jonathan R. LaRochelle, Jason R. Dobson, Hui Gao, Laura R. La Bonte, Huaixiang Hao, Rajesh Karki, Samuel B. Ho, Guizhi Yang, Markus Warmuth, Ping Zhu, Matthew J. LaMarche, Brant Firestone, Matthew J. Meyer, Stephen C. Blacklow, Edmund Price, Kathy Hsiao, Jorge Garcia-Fortanet, Zhuoliang Chen, Chen Christine Hiu-Tung, Palermo Mark G, Vesselina G. Cooke, Cary Fridrich, Jay Larrow, Ping Wang, Sarah Williams, Ying-Nan P. Chen, Subarna Shakya, William R. Sellers, Nicholas Keen, Jing Yuan, Michael Shultz, Gang Liu, Michelle Fodor, Michael G. Acker, Pascal D. Fortin, Ho Man Chan, Timothy Michael Ramsey, Zhan Deng, Ji-Hu Zhang, Mitsunori Kato, Dyuti Majumdar, Peter Fekkes, Minying Pu, Travis Stams
Publikováno v:
Cancer Research. 77:2084-2084
The non-receptor protein tyrosine phosphatase (PTP) SHP2 is an important component of RTK signaling in response to growth factor stimulus and sits just upstream of the RAS-MAPK signaling cascade. The first oncogenic phosphatase to be identified, SHP2
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 11:2111-2115
Two well-defined oxidative chlorination–cyclization processes have been developed for the stereoselective synthesis of a variety of 4-amido-isothiazolidinone oxide derivatives. The stereochemistry of the cyclization products was confirmed by X-ray
Autor:
Ronald L. Halterman, Zhuoliang Chen
Publikováno v:
Organometallics. 13:3932-3942
Publikováno v:
ChemInform. 23
Autor:
Ronald L. Halterman, Zhuoliang Chen
Publikováno v:
ChemInform. 23
Publikováno v:
ChemInform. 25