Zobrazeno 1 - 10
of 196
pro vyhledávání: '"Zhuohua Zhang"'
Autor:
Lu Geng, Wenqing Gao, Hexige Saiyin, Yuanyuan Li, Yu Zeng, Zhifei Zhang, Xue Li, Zuolong Liu, Qiang Gao, Ping An, Ning Jiang, Xiaofei Yu, Xiangjun Chen, Suhua Li, Lei Chen, Boxun Lu, Aiqun Li, Guoyuan Chen, Yidong Shen, Haibing Zhang, Mei Tian, Zhuohua Zhang, Jixi Li
Publikováno v:
Molecular Neurodegeneration, Vol 18, Iss 1, Pp 1-21 (2023)
Abstract Parkinson’s disease (PD), one of the most devastating neurodegenerative brain disorders, is characterized by the progressive loss of dopaminergic neurons in the substantia nigra (SN) and deposits of α-synuclein aggregates. Currently, phar
Externí odkaz:
https://doaj.org/article/79ee10d8aa2f4485b33d230d91c6cd8d
Drying Over Eastern China Driven by the Depletion of Arctic Stratospheric Ozone During Boreal Spring
Publikováno v:
Geophysical Research Letters, Vol 51, Iss 8, Pp n/a-n/a (2024)
Abstract Given the significant importance of spring precipitation for agricultural production in China and the presence of the spring predictability barrier, scientists have dedicated extensive efforts to understand the factors influencing spring pre
Externí odkaz:
https://doaj.org/article/5e94ca78db094192a06fe1064ef8c55a
Autor:
Haibin Yu, Dandan Liu, Yaowen Zhang, Ruijun Tang, Xunan Fan, Song Mao, Lu Lv, Fang Chen, Hongtao Qin, Zhuohua Zhang, Daan MF van Aalten, Bing Yang, Kai Yuan
Publikováno v:
eLife, Vol 13 (2024)
O-GlcNAcylation is a dynamic post-translational modification that diversifies the proteome. Its dysregulation is associated with neurological disorders that impair cognitive function, and yet identification of phenotype-relevant candidate substrates
Externí odkaz:
https://doaj.org/article/6c6eefd4c2924060b89bc0e379a659a4
Autor:
Bin He, Liping Quan, Chengban Li, Wei Yan, ZhuoHua Zhang, LiuFan Zhou, Qinjiang Wei, Zhile Li, Jianjiao Mo, Zhen Zhang, Xingshou Pan, JianJun Huang, Li Liu
Publikováno v:
Heliyon, Vol 10, Iss 5, Pp e25572- (2024)
Background: Dilated cardiomyopathy (DCM) is widely recognized as a significant contributor to heart failure. Nevertheless, the absence of pharmaceutical interventions capable of reversing disease progression and improving prognosis underscores the im
Externí odkaz:
https://doaj.org/article/6b4c16a252e04277b9ac66ab8c7f59a1
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 16 (2024)
Parkinson’s disease (PD) is the second most common neurodegenerative disease with currently no cure. Most PD cases are sporadic, and about 5–10% of PD cases present a monogenic inheritance pattern. Mutations in more than 20 genes are associated w
Externí odkaz:
https://doaj.org/article/e48b704dc34743ccb056568daae3516b
Publikováno v:
Axioms, Vol 13, Iss 5, p 320 (2024)
In this paper, we prove the stability of the Brunn–Minkowski inequality for multiple convex bodies in terms of the concept of relative asymmetry. Using these stability results and the relationship of the compact support of functions, we establish t
Externí odkaz:
https://doaj.org/article/a198f6b07a644158a85889c5a84deda2
Autor:
Hongxu Pan, Zhenhua Liu, Jinghong Ma, Yuanyuan Li, Yuwen Zhao, Xiaoxia Zhou, Yaqin Xiang, Yige Wang, Xun Zhou, Runcheng He, Yali Xie, Qiao Zhou, Kai Yuan, Qian Xu, Qiying Sun, Junling Wang, Xinxiang Yan, Hainan Zhang, Chunyu Wang, Lifang Lei, Weiguo Liu, Xuejing Wang, Xuebing Ding, Tao Wang, Zheng Xue, Zhentao Zhang, Ling Chen, Qing Wang, Yonghong Liu, Jiayu Tang, Xuewei Zhang, Shifang Peng, Chaodong Wang, Jianqing Ding, Chunfeng Liu, Lijuan Wang, Haibo Chen, Lu Shen, Hong Jiang, Xinyin Wu, Hongzhuan Tan, Dan Luo, Shuiyuan Xiao, Xiang Chen, Jieqiong Tan, Zhengmao Hu, Chao Chen, Kun Xia, Zhuohua Zhang, Jia Nee Foo, Cornelis Blauwendraat, Mike A. Nalls, Andrew B. Singleton, Jun Liu, Piu Chan, Houfeng Zheng, Jinchen Li, Jifeng Guo, Jian Yang, Beisha Tang, the Parkinson’s Disease & Movement Disorders Multicenter Database and Collaborative Network in China (PD-MDCNC)
Publikováno v:
npj Parkinson's Disease, Vol 9, Iss 1, Pp 1-11 (2023)
Abstract Genome-wide association studies (GWASs) have identified numerous susceptibility loci for Parkinson’s disease (PD), but its genetic architecture remains underexplored in populations of non-European ancestry. To identify genetic variants ass
Externí odkaz:
https://doaj.org/article/86fb62f9c0a34c348b16d10a5ad12710
Autor:
Panlin Liao, Yanchun Yuan, Zhen Liu, Xiaorong Hou, Wanzhen Li, Jin Wen, Kexuan Zhang, Bin Jiao, Lu Shen, Hong Jiang, Jifeng Guo, Beisha Tang, Zhuohua Zhang, Zhonghua Hu, Junling Wang
Publikováno v:
Translational Neurodegeneration, Vol 11, Iss 1, Pp 1-13 (2022)
Abstract Background Amyotrophic lateral sclerosis (ALS) is a devastating progressive neurodegenerative disease that affects neurons in the central nervous system and the spinal cord. As in many other neurodegenerative disorders, the genetic risk fact
Externí odkaz:
https://doaj.org/article/e622460aa7a44d2f899825593ad0ffc4
Autor:
Chunhong Yu, Xiaoyun Lei, Fang Chen, Song Mao, Lu Lv, Honglu Liu, Xueying Hu, Runhan Wang, Licong Shen, Na Zhang, Yang Meng, Yunfan Shen, Jiale Chen, Pishun Li, Shi Huang, Changwei Lin, Zhuohua Zhang, Kai Yuan
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
Here the authors show mutation of the BAF chromatin remodeler subunit ARID1A results in an ARID1B-dependent upregulation of HERVH, an ERV required for the pluripotency regulatory network. These HERVH RNAs can partition into BRD4 foci, affecting BRD4-
Externí odkaz:
https://doaj.org/article/1d0dd3de6fdc4b3681275cbd5f470c8c
Autor:
Zhenhua Liu, Nannan Yang, Jie Dong, Wotu Tian, Lisa Chang, Jinghong Ma, Jifeng Guo, Jieqiong Tan, Ao Dong, Kaikai He, Jingheng Zhou, Resat Cinar, Junbing Wu, Armando G. Salinas, Lixin Sun, Mantosh Kumar, Breanna T. Sullivan, Braden B. Oldham, Vanessa Pitz, Mary B. Makarious, Jinhui Ding, Justin Kung, Chengsong Xie, Sarah L. Hawes, Lupeng Wang, Tao Wang, Piu Chan, Zhuohua Zhang, Weidong Le, Shengdi Chen, David M. Lovinger, Cornelis Blauwendraat, Andrew B. Singleton, Guohong Cui, Yulong Li, Huaibin Cai, Beisha Tang
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
2- arachidonoylglycerol (2-AG), an abundant endocannabinoid in the brain, regulates diverse neural functions. Here, the authors identified four loss-of-function mutations in dicylglycerol lipase β (DAGLB) from six patients with early onset Parkinson
Externí odkaz:
https://doaj.org/article/4a94e3b86d214217aab9a2b47dae2413