Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Zhuofan Lei"'
Autor:
Chanhee Park, Zhuofan Lei, Yun Li, Boyang Ren, Junyun He, Huang Huang, Fengqian Chen, Hui Li, Kavitha Brunner, Jing Zhu, Steven M. Jay, Brittney Williams, Wei Chao, Junfang Wu, Lin Zou
Publikováno v:
Journal of Neuroinflammation, Vol 21, Iss 1, Pp 1-18 (2024)
Abstract Background Neuroinflammation reportedly plays a critical role in the pathogenesis of sepsis-associated encephalopathy (SAE). We previously reported that circulating plasma extracellular vesicles (EVs) from septic mice are proinflammatory. In
Externí odkaz:
https://doaj.org/article/d60a7bbe0e264e1fb338959b5dcccdc8
Publikováno v:
Cells, Vol 13, Iss 18, p 1584 (2024)
Spinal cord injury (SCI) triggers microglial/monocytes activation with distinct pro-inflammatory or inflammation-resolving phenotypes, which potentiate tissue damage or facilitate functional repair, respectively. The major integrin Mac-1 (CD11b/CD18)
Externí odkaz:
https://doaj.org/article/d26c20afb6504351977a2a9f4e69f842
Publikováno v:
Journal of Neuroinflammation, Vol 20, Iss 1, Pp 1-23 (2023)
Abstract Background Medical advances have made it increasingly possible for spinal cord injury (SCI) survivors to survive decades after the insult. But how SCI affects aging changes and aging impacts the injury process have received limited attention
Externí odkaz:
https://doaj.org/article/b803d186d5184b4782eb990906fa3386
Autor:
Wendy W. Yang, Jessica J. Matyas, Yun Li, Hangnoh Lee, Zhuofan Lei, Cynthia L. Renn, Alan I. Faden, Susan G. Dorsey, Junfang Wu
Publikováno v:
Cells, Vol 13, Iss 9, p 759 (2024)
Strain differences have been reported for motor behaviors, and only a subset of spinal cord injury (SCI) patients develop neuropathic pain, implicating genetic or genomic contribution to this condition. Here, we evaluated neuropsychiatric behaviors i
Externí odkaz:
https://doaj.org/article/203884880b32467aa70a941d920b6a2e
Autor:
Brendan Puls, Yan Ding, Fengyu Zhang, Mengjie Pan, Zhuofan Lei, Zifei Pei, Mei Jiang, Yuting Bai, Cody Forsyth, Morgan Metzger, Tanvi Rana, Lei Zhang, Xiaoyun Ding, Matthew Keefe, Alice Cai, Austin Redilla, Michael Lai, Kevin He, Hedong Li, Gong Chen
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 8 (2020)
Spinal cord injury (SCI) often leads to impaired motor and sensory functions, partially because the injury-induced neuronal loss cannot be easily replenished through endogenous mechanisms. In vivo neuronal reprogramming has emerged as a novel technol
Externí odkaz:
https://doaj.org/article/1a07aef89a7545cc974b29af742685e0
Autor:
Lei Zhang, Zhuofan Lei, Ziyuan Guo, Zifei Pei, Yuchen Chen, Fengyu Zhang, Alice Cai, Gabriel Mok, Grace Lee, Vishal Swaminathan, Fan Wang, Yuting Bai, Gong Chen
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 14 (2020)
Injuries in the central nervous system (CNS) often causes neuronal loss and glial scar formation. We have recently demonstrated NeuroD1-mediated direct conversion of reactive glial cells into functional neurons in adult mouse brains. Here, we further
Externí odkaz:
https://doaj.org/article/ef8319f2130841b89b01b4f9cd97c751
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 11 (2017)
Associative learning is a common way for information acquisition, and the integrative storage of multiple associated signals is essential for associative thinking and logical reasoning. In terms of the cellular mechanism for associative memory, our s
Externí odkaz:
https://doaj.org/article/94677be70bca4cb3916136ba3d2adbfe
Autor:
Zhuofan Lei, Balaji Krishnamachary, Rodney M. Ritzel, Niaz Z. Khan, Yun Li, Hui Li, Kavitha Brunner, Alan I. Faden, Junfang Wu
Approximately 20% of all spinal cord injuries (SCI) occur in persons aged 65 years or older. Longitudinal, population-based studies showed that SCI is a risk factor for dementia. However, little research has addressed the potential mechanisms of SCI-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::352b3e423399042a2c6ff96c7030d865
https://doi.org/10.21203/rs.3.rs-2821858/v1
https://doi.org/10.21203/rs.3.rs-2821858/v1
Autor:
Rodney M. Ritzel, Yun Li, Yun Jiao, Zhuofan Lei, Sarah J. Doran, Junyun He, Rami A. Shahror, Rebecca J. Henry, Romeesa Khan, Chunfeng Tan, Shaolin Liu, Bogdan A. Stoica, Alan I. Faden, Gregory Szeto, David J. Loane, Junfang Wu
Publikováno v:
Science Advances. 9
Lipofuscin is an autofluorescent (AF) pigment formed by lipids and misfolded proteins, which accumulates in postmitotic cells with advanced age. Here, we immunophenotyped microglia in the brain of old C57BL/6 mice (>18 months old) and demonstrate tha
Autor:
Rodney M. Ritzel, Yun Li, Zhuofan Lei, Jordan Carter, Junyun He, Harry M. C. Choi, Niaz Khan, Hui Li, Samantha Allen, Marta M. Lipinski, Alan I. Faden, Junfang Wu
Publikováno v:
GeroScience. 44:1407-1440
Elderly patients with traumatic brain injury (TBI) have greater mortality and poorer outcomes than younger individuals. The extent to which old age alters long-term recovery and chronic microglial activation after TBI is unknown, and evidence for the