Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Zhuocheng Su"'
Autor:
Kevin K Ogden, Wenjuan Chen, Sharon A Swanger, Miranda J McDaniel, Linlin Z Fan, Chun Hu, Anel Tankovic, Hirofumi Kusumoto, Gabrielle J Kosobucki, Anthony J Schulien, Zhuocheng Su, Joseph Pecha, Subhrajit Bhattacharya, Slavé Petrovski, Adam E Cohen, Elias Aizenman, Stephen F Traynelis, Hongjie Yuan
Publikováno v:
PLoS Genetics, Vol 13, Iss 1, p e1006536 (2017)
N-methyl-D-aspartate receptors (NMDARs), ligand-gated ionotropic glutamate receptors, play key roles in normal brain development and various neurological disorders. Here we use standing variation data from the human population to assess which protein
Externí odkaz:
https://doaj.org/article/60f8bb0309e04853b4d0c688c30b36ad
Publikováno v:
The Journal of General Physiology
Mammalian hyperpolarization-activated cyclic-nucleotide–modulated (HCN) channels bind cAMP preferably in the open state. Using sea urchin HCN channels, Idikuda et al. reveal less cAMP binding to the closed state and further reduced binding to the i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec242aa4d9c17acbd11748c4e7c3e3fa
https://doi.org/10.1085/jgp.201812019
https://doi.org/10.1085/jgp.201812019
Singlet oxygen modification abolishes voltage-dependent inactivation of the sea urchin spHCN channel
Publikováno v:
The Journal of General Physiology
Singlet oxygen modifies several different proteins within cells. Idikuda et al. show that, in the case of the sea urchin hyperpolarization-activated cyclic nucleotide–gated channel, a histidine residue in S6 is essential for the abolition of voltag
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf30e0db3e955f71b5018558ffffdf70
https://doi.org/10.1085/jgp.201711961
https://doi.org/10.1085/jgp.201711961
Publikováno v:
The Journal of General Physiology
The number of channels on a patch of membrane is a fundamental quantity for biophysical studies of ion channel mechanisms. Liu et al. develop a new method of channel counting based on patch-clamp fluorometry and use it to measure the single-channel c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e3b79075c7588f41649d5a44557a957
http://europepmc.org/articles/PMC4924933
http://europepmc.org/articles/PMC4924933
Publikováno v:
The Journal of General Physiology
Singlet oxygen acts through a histidine residue to delay HCN channel deactivation and enhance voltage-insensitive current.
Singlet oxygen (1O2), which is generated through metabolic reactions and oxidizes numerous biological molecules, has been
Singlet oxygen (1O2), which is generated through metabolic reactions and oxidizes numerous biological molecules, has been
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0bce4996d9a45355488164dd532a3b90
https://doi.org/10.1085/jgp.201311112
https://doi.org/10.1085/jgp.201311112
Autor:
Shengjun Wu, Qinglian Liu, Changan Xie, Lei Zhou, Zhuocheng Su, Sabisha Shrestha, Weihua Gao, Farzana Marni, Faik N. Musayev, Xinping Xu
Publikováno v:
Structure (London, England : 1993). 20(12)
SummaryHyperpolarization-activated, cAMP-gated (HCN) channels sense membrane potential and intracellular cAMP levels. A mutation identified in the cAMP binding domain (CNBD) of the human HCN4 channel, S672R, severely reduces the heart rate, but the m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::701eac5847aa943ec3eeddd11c22a976
https://pubmed.ncbi.nlm.nih.gov/23217679
https://pubmed.ncbi.nlm.nih.gov/23217679
Publikováno v:
Biophysical Journal. 108:290a
The hyperpolarization activated cyclic nucleotide gated ion channels (HCN channels) are nonspecific cation channels that play vital role in the generation of rhythmic activities in the brain and the heart. Among the various members of HCN channels, s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02bc93ea0cb35b1ee93a5abd3af7ca3e
https://doi.org/10.1016/j.bpj.2014.11.1582
https://doi.org/10.1016/j.bpj.2014.11.1582
Publikováno v:
Biophysical Journal. 106:758a
Molecule oxygen has three electronic configurations, the triplet ground state, the first and the second singlet excited states. Singlet oxygen (1O2) is highly reactive and oxidizes a wide range of biomolecules including DNA and protein. Because of th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a3e1d8c1730a7112d27a75570fcd627
https://doi.org/10.1016/j.bpj.2013.11.4170
https://doi.org/10.1016/j.bpj.2013.11.4170
Publikováno v:
Biophysical Journal. 104:278a
Direct estimation of the number of channels on a membrane path is important for channel biophysics. It is a classical question and has been addressed elegantly by previous studies. Especially, pioneering researchers took the advantage of fluctuations
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e67af8bb6e0a6347b95c53007440ed8
https://doi.org/10.1016/j.bpj.2012.11.1562
https://doi.org/10.1016/j.bpj.2012.11.1562
Publikováno v:
Biophysical Journal. 104:278a
In response to both voltage and ligand, HCN channels play important physiological roles in the brain and the heart. HCN channels are activated by membrane hyperpolarization and the direct binding of intracellular cAMP. The spHCN channel was cloned fr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c806d4e8f40957c5479982d0afb33bd5
https://doi.org/10.1016/j.bpj.2012.11.1561
https://doi.org/10.1016/j.bpj.2012.11.1561