Zobrazeno 1 - 10
of 169
pro vyhledávání: '"Zhuo-wei Hu"'
Autor:
Feng Wang, Yunxuan Li, Zhaona Yang, Wenbin Cao, Ying Liu, Luyao Zhao, Tingting Zhang, Chenxi Zhao, Jinmei Yu, Jiaojiao Yu, Jichao Zhou, Xiaowei Zhang, Ping-Ping Li, Mingzhe Han, Sizhou Feng, Billy Wai-Lung Ng, Zhuo-Wei Hu, Erlie Jiang, Ke Li, Bing Cui
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract Dysregulated hematopoietic niches remodeled by leukemia cells lead to imbalances in immunological mediators that support leukemogenesis and drug resistance. Targeting immune niches may ameliorate disease progression and tyrosine kinase inhib
Externí odkaz:
https://doaj.org/article/a0b495b6660245fb8cd8dc9c76ab3a66
Autor:
Ji-Chao Zhou, Cai-Cai Jin, Xiao-Li Wei, Rui-Bing Xu, Ruo-Yu Wang, Zhi-Meng Zhang, Bo Tang, Jin-Mei Yu, Jiao-Jiao Yu, Shuang Shang, Xiao-Xi Lv, Fang Hua, Ping-Ping Li, Zhuo-Wei Hu, Yong-Mei Shen, Feng-Peng Wang, Xiu-Ying Ma, Bing Cui, Fu-Neng Geng, Xiao-Wei Zhang
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Aberrant mitophagy has been identified as a driver for energy metabolism disorder in most cardiac pathological processes. However, finding effective targeted agents and uncovering their precise modulatory mechanisms remain unconquered. Fuzi, the late
Externí odkaz:
https://doaj.org/article/ac2647d0d2cd476885f204369d00439a
Autor:
Ke Li, Feng Wang, Zhao-na Yang, Ting-ting Zhang, Yu-fen Yuan, Chen-xi Zhao, Zaiwuli Yeerjiang, Bing Cui, Fang Hua, Xiao-xi Lv, Xiao-wei Zhang, Jiao-jiao Yu, Shan-shan Liu, Jin-mei Yu, Shuang Shang, Yang Xiao, Zhuo-wei Hu
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-20 (2020)
c-MYC is often deregulated in human cancers including lymphomas. Here, the authors show that a member of the pseudokinase family, tribbles homologue 3 (TRIB3), interacts with c-MYC to suppress c-MYC ubiquitination and degradation, leading to increase
Externí odkaz:
https://doaj.org/article/9c78c5b2b4e747f5a5bbf0ce19770f93
Autor:
Jiao-jiao Yu, Dan-dan Zhou, Xiao-xiao Yang, Bing Cui, Feng-wei Tan, Junjian Wang, Ke Li, Shuang Shang, Cheng Zhang, Xiao-xi Lv, Xiao-wei Zhang, Shan-shan Liu, Jin-mei Yu, Feng Wang, Bo Huang, Fang Hua, Zhuo-Wei Hu
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
Depletion of tribbles pseudokinase 3 (TRIB3) is known to suppress the expression of several tumor-promoting factors, including EGFR. Here, the authors show that TRIB3 interacts with EGFR and regulates its stability and activity, and perturbing EGFR-T
Externí odkaz:
https://doaj.org/article/dd56caddb5794e359d42000db61b7459
Autor:
Jin-mei Yu, Wei Sun, Zhen-he Wang, Xiao Liang, Fang Hua, Ke Li, Xiao-xi Lv, Xiao-wei Zhang, Yu-ying Liu, Jiao-jiao Yu, Shan-shan Liu, Shuang Shang, Feng Wang, Zhao-na Yang, Chen-xi Zhao, Xue-ying Hou, Ping-ping Li, Bo Huang, Bing Cui, Zhuo-Wei Hu
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
Cancer stem cells contribute to breast cancer metastasis and recurrence. Here the authors show that TRIB3 enhances breast cancer stemness through interaction with AKT to promote FOXO1 stability, which then increases SOX2 activity.
Externí odkaz:
https://doaj.org/article/b1e7a79e5d3d4b7f8ef165185b467013
Autor:
Yuying Liu, Xiaoyu Liang, Xiaonan Yin, Jiadi Lv, Ke Tang, Jingwei Ma, Tiantian Ji, Huafeng Zhang, Wenqian Dong, Xun Jin, Degao Chen, Yanchun Li, Songyan Zhang, Heidi Q. Xie, Bin Zhao, Tong Zhao, Jinzhi Lu, Zhuo-Wei Hu, Xuetao Cao, F. Xiao-Feng Qin, Bo Huang
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
Tumour repopulating cells (TRC) are stem-like cells that can escape immune-mediated killing. Here, the authors show IFN-γ results in either dormancy or apoptosis of TRC depending on the activation of the IDO1 metabolic pathway, and that combining IF
Externí odkaz:
https://doaj.org/article/20f327dfca6c464ba7984c61c7778da5
Autor:
Peng Liu, Hua‐Yan Bao, Cai‐Cai Jin, Ji‐Chao Zhou, Fang Hua, Ke Li, Xiao‐Xi Lv, Bing Cui, Zhuo‐Wei Hu, Xiao‐Wei Zhang
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 8, Iss 20 (2019)
Background Heart failure (HF) is one of the most significant causes of morbidity and mortality for the cardiovascular risk population. We found previously that extracellular HSP70 (heat shock protein) is an important trigger in cardiac hypertrophy an
Externí odkaz:
https://doaj.org/article/c5982cc2dfc140b99a5cfba04d533994
Publikováno v:
Molecular & Cellular Oncology, Vol 4, Iss 4 (2017)
Pseudokinase tribbles (Trib) family, Trib1 and Trib2, but not Trib3, act as oncogene to drive acute leukemia by destabilizing the myeloid transcription factor CCAAT/enhancer-binding protein α (C/EBPα) and inhibiting myeloid differentiation. A recen
Externí odkaz:
https://doaj.org/article/e2ddb2546c50406692f735a91d4cf7d6
Publikováno v:
PLoS ONE, Vol 8, Iss 7, p e68631 (2013)
A similar immune response is implicated in the pathogenesis of pulmonary fibrosis and allergic disorders. We investigated the potential therapeutic efficacy and mechanism of rupatadine, a dual antagonist of histamine and platelet-activation factor (P
Externí odkaz:
https://doaj.org/article/a2df4253bba44592b64c9ed8a389f629
Publikováno v:
PLoS ONE, Vol 8, Iss 10, p e74130 (2013)
Hepatocellular carcinoma (HCC) remains one of the most deadly solid tumor malignancies worldwide. We recently find that the loss of toll-like receptor 2 (TLR2) activities promotes the diethylnitrosamine (DEN) induced hepatocellular carcinogenesis and
Externí odkaz:
https://doaj.org/article/31ff1923d41b4167af1b9d4a98aa8133