Zobrazeno 1 - 10
of 65
pro vyhledávání: '"Zhuo-Hua Pan"'
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 18, Iss , Pp 15-23 (2020)
The loss of photoreceptors in individuals with retinal degenerative diseases leads to partial or complete blindness. Optogenetic therapy is a promising approach for restoring vision to the blind. Multiple strategies have been employed by targeting ge
Externí odkaz:
https://doaj.org/article/efb8d8de260f40978eadb453d1fb108d
Publikováno v:
PLoS ONE, Vol 10, Iss 11, p e0142052 (2015)
The axon initial segment (AIS) is essential for initiating action potentials and maintaining neuronal excitability in axon-bearing neurons in the CNS. There is increasing interest in the targeting of optogenetic tools to subcellular compartments, inc
Externí odkaz:
https://doaj.org/article/4d006416f66e44b9a947b0bf1dfe5aaf
Publikováno v:
PLoS ONE, Vol 9, Iss 6, p e98924 (2014)
The ectopic expression of microbial opsin-based optogenetic sensors, such as channelrhodopsin-2 (ChR2) in surviving inner retinal neurons, is a promising approach to restoring vision after retinal degeneration. However, a major limitation in using na
Externí odkaz:
https://doaj.org/article/246b2f216f454782acaefa34a78918f1
Publikováno v:
PLoS ONE, Vol 8, Iss 6, p e66332 (2013)
Expression of optogenetic tools in surviving inner retinal neurons to impart retinal light sensitivity has been a new strategy for restoring vision after photoreceptor degeneration. One potential approach for restoring retinal light sensitivity after
Externí odkaz:
https://doaj.org/article/ff9e748af6ba454f9015d19adc502d9d
Autor:
Camasamudram Vijayasarathy, Yong Zeng, Dario Marangoni, Lijin Dong, Zhuo-Hua Pan, Elizabeth M. Simpson, Robert N. Fariss, Paul A. Sieving
Publikováno v:
Investigative ophthalmology & visual science, vol 63, iss 11
PurposeLoss of retinoschisin (RS1) function underlies X-linked retinoschisis (XLRS) pathology. In the retina, both photoreceptor inner segments and bipolar cells express RS1. However, the loss of RS1 function causes schisis primarily in the inner ret
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b490931997a78774f2eae794406f4ac
https://escholarship.org/uc/item/78q6t7m5
https://escholarship.org/uc/item/78q6t7m5
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 18, Iss, Pp 15-23 (2020)
Molecular Therapy. Methods & Clinical Development
Molecular Therapy. Methods & Clinical Development
The loss of photoreceptors in individuals with retinal degenerative diseases leads to partial or complete blindness. Optogenetic therapy is a promising approach for restoring vision to the blind. Multiple strategies have been employed by targeting ge
Effect of Proteasome Inhibitors on the AAV-Mediated Transduction Efficiency in Retinal Bipolar Cells
Publikováno v:
Current Gene Therapy. 19:404-412
Background: Adeno-associated Virus (AAV) vectors are the most promising vehicles for therapeutic gene delivery to the retina. To develop a practical gene delivery tool, achieving high AAV transduction efficiency in specific cell types is often requir
Autor:
Valentina Emiliani, Emilia Entcheva, Rainer Hedrich, Peter Hegemann, Kai R. Konrad, Christian Lüscher, Mathias Mahn, Zhuo-Hua Pan, Ruth R. Sims, Johannes Vierock, Ofer Yizhar
Publikováno v:
NAURE REVIEWS | METhOdS PrimE
Nature Reviews Methods Primers
Nature Reviews Methods Primers, 2022, 2, pp.55. ⟨10.1038/s43586-022-00136-4⟩
Nature Reviews Methods Primers
Nature Reviews Methods Primers, 2022, 2, pp.55. ⟨10.1038/s43586-022-00136-4⟩
International audience; Optogenetic techniques have been developed to allow control over the activity of selected cells within a highly heterogeneous tissue, using a combination of genetic engineering and light. Optogenetics employs natural and engin
Autor:
Qi, Lu, Zhuo-Hua, Pan
Publikováno v:
Advances in experimental medicine and biology. 1293
The loss of photoreceptor cells caused by retinal degenerative diseases leads to blindness. The optogenetic approach for restoring vision involves converting the surviving inner retinal neurons into photosensitive cells, thus imparting light sensitiv
Autor:
Zhuo-Hua Pan, Qi Lu
Publikováno v:
Advances in Experimental Medicine and Biology ISBN: 9789811587627
The loss of photoreceptor cells caused by retinal degenerative diseases leads to blindness. The optogenetic approach for restoring vision involves converting the surviving inner retinal neurons into photosensitive cells, thus imparting light sensitiv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::05f4585f69e6e45ad2ae0742c635bf7a
https://doi.org/10.1007/978-981-15-8763-4_38
https://doi.org/10.1007/978-981-15-8763-4_38