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Akademický článek

Stochastic RNA editing of the Complexin C-terminus within single neurons regulates neurotransmitter release

Autor: Elizabeth A. Brija, Zhuo Guan, Suresh K. Jetti, J. Troy Littleton

Publikováno v: Cell Reports, Vol 42, Iss 9, Pp 113152- (2023)

Summary: Neurotransmitter release requires assembly of the SNARE complex fusion machinery, with multiple SNARE-binding proteins regulating when and where synaptic vesicle fusion occurs. The presynaptic protein Complexin (Cpx) controls spontaneous and

Externí odkaz: https://doaj.org/article/65f65c0673bb4aa78e4790b769dd0ec2

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Akademický článek

Drosophila Synaptotagmin 7 negatively regulates synaptic vesicle release and replenishment in a dosage-dependent manner

Autor: Zhuo Guan, Monica C Quiñones-Frías, Yulia Akbergenova, J Troy Littleton

Publikováno v: eLife, Vol 9 (2020)

Synchronous neurotransmitter release is triggered by Ca2+ binding to the synaptic vesicle protein Synaptotagmin 1, while asynchronous fusion and short-term facilitation is hypothesized to be mediated by plasma membrane-localized Synaptotagmin 7 (SYT7

Externí odkaz: https://doaj.org/article/e4534965bc0e4d46978afeb75b413c4d

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Akademický článek

A synaptotagmin suppressor screen indicates SNARE binding controls the timing and Ca2+ cooperativity of vesicle fusion

Autor: Zhuo Guan, Maria Bykhovskaia, Ramon A Jorquera, Roger Bryan Sutton, Yulia Akbergenova, J Troy Littleton

Publikováno v: eLife, Vol 6 (2017)

The synaptic vesicle Ca2+ sensor Synaptotagmin binds Ca2+ through its two C2 domains to trigger membrane interactions. Beyond membrane insertion by the C2 domains, other requirements for Synaptotagmin activity are still being elucidated. To identify

Externí odkaz: https://doaj.org/article/796dd2201f724a17b712406d80733c18

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