Zobrazeno 1 - 10
of 84
pro vyhledávání: '"Zhumei Shi"'
Autor:
Jianxing Yin, Xiefeng Wang, Xin Ge, Fangshu Ding, Zhumei Shi, Zehe Ge, Guang Huang, Ningwei Zhao, Dongyin Chen, Junxia Zhang, Sameer Agnihotri, Yuandong Cao, Jing Ji, Fan Lin, Qianghu Wang, Qigang Zhou, Xiuxing Wang, Yongping You, Zhimin Lu, Xu Qian
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract Temozolomide (TMZ) is a standard treatment for glioblastoma (GBM) patients. However, TMZ has moderate therapeutic effects due to chemoresistance of GBM cells through less clarified mechanisms. Here, we demonstrate that TMZ-derived 5-aminoimi
Externí odkaz:
https://doaj.org/article/222d6b61d74e4688bf6df0cc6f4060e8
Autor:
Jianxing Yin, Fangshu Ding, Zhangchun Cheng, Xin Ge, Yanhui Li, Ailiang Zeng, Junxia Zhang, Wei Yan, Zhumei Shi, Xu Qian, Yongping You, Zhiliang Ding, Jing Ji, Xiefeng Wang
Publikováno v:
Cell Death and Disease, Vol 14, Iss 7, Pp 1-12 (2023)
Abstract Long noncoding RNAs (lncRNAs) are involved in glioma initiation and progression. Glioma stem cells (GSCs) are essential for tumor initiation, maintenance, and therapeutic resistance. However, the biological functions and underlying mechanism
Externí odkaz:
https://doaj.org/article/99f11da15a63462d9198ce0ec0f0d457
Autor:
Zehe Ge, Miao Xu, Yuqian Ge, Guang Huang, Dongyin Chen, Xiuquan Ye, Yibei Xiao, Hongyu Zhu, Rong Yin, Hua Shen, Gaoxiang Ma, Lianwen Qi, Guining Wei, Dongmei Li, Shaofeng Wei, Meng Zhu, Hongxia Ma, Zhumei Shi, Xiuxing Wang, Xin Ge, Xu Qian
Publikováno v:
Cell Reports, Vol 42, Iss 11, Pp 113417- (2023)
Summary: EGFRT790M mutation causes resistance to the first-generation tyrosine kinase inhibitors (TKIs) in patients with non-small cell lung cancer (NSCLC). However, the therapeutic options for sensitizing first TKIs and delaying the emergence of EGF
Externí odkaz:
https://doaj.org/article/ec090f4525f04a58bf83e4527871ab54
Autor:
Xin Ge, Mengdie Li, Guo‐Xin Song, Zhixiang Zhang, Jianxing Yin, Zehe Ge, Zhumei Shi, Ling‐Zhi Liu, Bing‐Hua Jiang, Xu Qian, Hua Shen
Publikováno v:
Clinical and Translational Medicine, Vol 12, Iss 12, Pp n/a-n/a (2022)
Abstract Cr(VI) is broadly applied in industry. Cr(VI) exposure places a big burden on public health, thereby increasing the risk of lung squamous cell carcinoma (LUSC). The mechanisms underlying Cr(VI)‐induced LUSC remain largely elusive. Here, we
Externí odkaz:
https://doaj.org/article/f7e632d741dc495897d557946aa5f81f
Autor:
JianXing Yin, ZhuMei Shi, WenJin Wei, Chenfei Lu, Yutian Wei, Wei Yan, Rui Li, JunXia Zhang, YongPing You, XieFeng Wang
Publikováno v:
Cancer Cell International, Vol 20, Iss 1, Pp 1-12 (2020)
Abstract Background Glucose metabolic reprogramming is a significant hallmark of malignant tumors including GBM. Previous studies suggest that microRNAs play key roles in modulating this process in GBM cells. miR-181b acts as a tumor suppressor miRNA
Externí odkaz:
https://doaj.org/article/451822e6911749b5be910185049f4ef9
Autor:
Chenfei Lu, Yutian Wei, Xiefeng Wang, Zhuoran Zhang, Jianxing Yin, Wentao Li, Lijiu Chen, Xiao Lyu, Zhumei Shi, Wei Yan, Yongping You
Publikováno v:
Molecular Cancer, Vol 19, Iss 1, Pp 1-19 (2020)
Abstract Background Accumulating evidence shows that long noncoding RNAs (lncRNAs) are important regulator molecules involved in diverse biological processes. Acquired drug resistance is a major challenge in the clinical treatment of glioblastoma (GB
Externí odkaz:
https://doaj.org/article/0478454b0efe490085728f5f7fd46931
Autor:
Yunxia Xie, Zhumei Shi, Yingchen Qian, Chengfei Jiang, Wenjing Liu, Bingjie Liu, Binghua Jiang
Publikováno v:
Cancers, Vol 14, Iss 15, p 3600 (2022)
Background: Breast cancer has one of highest morbidity and mortality rates for women. Abnormalities regarding epigenetics modification and pyruvate dehydrogenase kinase 1 (PDK1)-induced unusual metabolism contribute to breast cancer progression and c
Externí odkaz:
https://doaj.org/article/572e469019354ffb8c44b06faf3df364
Publikováno v:
EBioMedicine, Vol 42, Iss , Pp 238-251 (2019)
Background: Although temozolomide (TMZ) resistance is a significant clinical problem in glioblastoma (GBM), its underlying molecular mechanisms are poorly understood. In this study, we identified the role of exosomal microRNAs (miRNAs) from TMZ-resis
Externí odkaz:
https://doaj.org/article/8ba8a89453534d148e1864f02481a522
Publikováno v:
International Journal of Molecular Sciences, Vol 13, Iss 6, Pp 7271-7282 (2012)
Apigenin, a flavonoid commonly present in the daily diet, is known for its potential anti-tumor properties. However, the effect of apigenin via oral administration on tumor growth and metastasis remains unknown. In this study we developed an orthotop
Externí odkaz:
https://doaj.org/article/d970dc05a61b4efaa0ea294511e4612f
Autor:
Hua Shen, Fang Zhu, Jinyuan Liu, Tongpeng Xu, Dong Pei, Rong Wang, Yingying Qian, Qi Li, Lin Wang, Zhumei Shi, Jitai Zheng, Qiudan Chen, Binghua Jiang, Yongqian Shu
Publikováno v:
PLoS ONE, Vol 9, Iss 7, p e103305 (2014)
Resistance to TKI treatment is a major obstacle in effective treatment of NSCLC. Besides EGFR mutation status, the mechanisms involved are largely unknown. Some evidence supports a role for microRNA 21 in modulating drug sensitivity of chemotherapy b
Externí odkaz:
https://doaj.org/article/e33e3ae9177e4b7b9b1d7195a00d255b