Nephronectin Regulates Mesangial Cell Adhesion and Behavior in Glomeruli

Autor: Zhufeng Yang, Chitkale Hiremath, Denise K. Marciano, Jun Tsunezumi, Bronwyn Finney, Susan E. Zimmerman

Publikováno v: Journal of the American Society of Nephrology. 29:1128-1140

A critical aspect of kidney function occurs at the glomerulus, the capillary network that filters the blood. The glomerular basement membrane (GBM) is a key component of filtration, yet our understanding of GBM interactions with mesangial cells, spec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6872f1abdb8f76489cc8b73fb79198c7
https://doi.org/10.1681/asn.2017070752

Role of CD34 family members in lumen formation in the developing kidney

Autor: David M. Bryant, Consuelo González-Manchón, Jun Tsunezumi, Susan E. Zimmerman, Zhufeng Yang, Cary Trent, Caitlin M. Braitsch, Ondine Cleaver, Denise K. Marciano

Publikováno v: Developmental Biology. 418:66-74

Previous studies have shown CD34 family member Podocalyxin is required for epithelial lumen formation in vitro. We demonstrate that Endoglycan, a CD34 family member with homology to Podocalyxin, is produced prior to lumen formation in developing neph

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ef3fcc62d03930fec09258bade75dc0
https://doi.org/10.1016/j.ydbio.2016.08.009

Afadin orients cell division to position the tubule lumen in developing renal tubules

Autor: Lei, Gao, Zhufeng, Yang, Chitkale, Hiremath, Susan E, Zimmerman, Blake, Long, Paul R, Brakeman, Keith E, Mostov, David M, Bryant, Katherine, Luby-Phelps, Denise K, Marciano

Publikováno v: Development (Cambridge, England). 144(19)

In many types of tubules, continuity of the lumen is paramount to tubular function, yet how tubules generate lumen continuity in vivo is not known. We recently found that the F-actin-binding protein afadin is required for lumen continuity in developi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::7d64ef9f58095dfb3ae804d6cc682862
https://pubmed.ncbi.nlm.nih.gov/28860115

Genes involved in the immediate early response and epithelial-mesenchymal transition are regulated by adipocytokines in the female reproductive tract

Autor: Jennifer R. Wood, Zhufeng Yang, Jacqueline E. Smith, Kristin A. Norwood, Jill G. Kerl

Publikováno v: Molecular Reproduction and Development. 79:128-137

Obesity increases the risk of female reproductive tract cancers, but the underlying mechanistic link between the two is ill-defined. Thus, the objective of the current study was to identify obesity-dependent changes in the expression of immediate ear

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6ea3cb9d2b145f8440389ae1ea7b1811
https://doi.org/10.1002/mrd.22006

De novo lumen formation and elongation in the developing nephron: a central role for afadin in apical polarity

Autor: Denise K. Marciano, Zhufeng Yang, Susan E. Zimmerman, Gerard M.J. Beaudoin, Paul Brakeman, Louis F. Reichardt

Publikováno v: Development (Cambridge, England), vol 140, iss 8
Yang, Z; Zimmerman, S; Brakeman, PR; Beaudoin, GM; Reichardt, LF; & Marciano, DK. (2013). De novo lumen formation and elongation in the developing nephron: A central role for afadin in apical polarity. Development (Cambridge), 140(8), 1774-1784. doi: 10.1242/dev.087957. UCSF: Retrieved from: http://www.escholarship.org/uc/item/5kj5k9px

A fundamental process in biology is the de novo formation and morphogenesis of polarized tubules. Although these processes are essential for the formation of multiple metazoan organ systems, little is known about the molecular mechanisms that regulat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37389d82c87a8252d584cacb3c732ebf
https://escholarship.org/uc/item/5kj5k9px