Zobrazeno 1 - 10
of 113
pro vyhledávání: '"Zhufang Shen"'
Autor:
Caina Li, Quan Liu, Wenming Ji, Yaxin Fu, Hui Cao, Yi Huan, Lei Lei, Xuefeng Gao, Leilei Chen, Cunyu Feng, Lin Zhang, Pingping Li, Yuling Liu, Shuainan Liu, Zhufang Shen
Publikováno v:
Frontiers in Medicine, Vol 10 (2023)
BackgroundMorus alba L. (Sangzhi) alkaloid (SZ-A) is a new antidiabetic drug approved by the China National Medical Products Administration in 2020. Diabetic nephropathy (DN) is a common diabetic complication and an important cause of morbidity and m
Externí odkaz:
https://doaj.org/article/8c0f27381978470589ada8972492d059
Autor:
Zhihua Liu, Yu Feng, Hang Zhao, Jinping Hu, Yanmin Chen, Dongdong Liu, Hongliang Wang, Xiangyang Zhu, Hongzhen Yang, Zhufang Shen, Xuejun Xia, Jun Ye, Yuling Liu
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Ramulus Mori (Sangzhi) alkaloids (SZ-A) derived from twigs of mulberry (Morus alba L., genus Morus in the Moraceae family) was approved by the National Medical Products Administration in 2020 for the treatment of type 2 diabetes mellitus. In addition
Externí odkaz:
https://doaj.org/article/185c18b314414fb29cbed8e71779dd5e
Autor:
Lei Lei, Yi Huan, Quan Liu, Caina Li, Hui Cao, Wenming Ji, Xuefeng Gao, Yaxin Fu, Pingping Li, Ruiping Zhang, Zeper Abliz, Yuling Liu, Shuainan Liu, Zhufang Shen
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Background:Morus alba L. (Sangzhi) alkaloids (SZ-A), extracted from the Chinese herb Morus alba L. (mulberry twig), have been shown to ameliorate hyperglycemia in type 2 diabetes and have been approved for diabetes treatment in the clinic. However, t
Externí odkaz:
https://doaj.org/article/4eb8440a0e5940e090c967064e9e4173
Autor:
Quan Liu, Shuainan Liu, Hui Cao, Wenming Ji, Caina Li, Yi Huan, Lei Lei, Yaxin Fu, Xuefeng Gao, Yuling Liu, Zhufang Shen
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
The novel Traditional Chinese Medicine Ramulus Mori (Sangzhi) alkaloid tablets (SZ-A) are approved by The China National Medical Products Administration for the treatment of type 2 diabetes mellitus (T2DM). However, the extensive pharmacological char
Externí odkaz:
https://doaj.org/article/28c0d111efee44d79545e5b6e5f08fc8
Autor:
Hui Cao, Caina Li, Lei Lei, Xing Wang, Shuainan Liu, Quan Liu, Yi Huan, Sujuan Sun, Zhufang Shen
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2020)
Berberine (BBR) has the beneficial effects of anti-inflammation, anti-bacteria, and anti-diabetes. The clinical application of BBR has been hindered by its poor gastrointestinal absorption. Stachyose (Sta), a prebiotic agent, improves the composition
Externí odkaz:
https://doaj.org/article/77e9be366b214f3f8fc57a9994e87b68
Autor:
Quan Liu, Shuainan Liu, Lihui Gao, Sujuan Sun, Yi Huan, Caina Li, Yue Wang, Nan Guo, Zhufang Shen
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 7, Iss 4, Pp 461-469 (2017)
Refined-JQ (JQ-R) is a mixture of refined extracts from Coptis chinensis (Ranunculaceae), Astragalus membranaceus (Leguminosae) and Lonicera japonica (Caprifoliaceae), the three major herbs of JinQi-JiangTang tablet, a traditional Chinese medicine (T
Externí odkaz:
https://doaj.org/article/41eee409fa084192953adc5cb795f528
Autor:
Yi Huan, Qian Jiang, Gang Li, Guoliang Bai, Tian Zhou, Shuainan Liu, Caina Li, Quan Liu, Sujuan Sun, Miaomiao Yang, Nan Guo, Xing Wang, Shusen Wang, Yaojuan Liu, Guanqiao Wang, Haihong Huang, Zhufang Shen
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
Abstract Glucagon like peptide-1 (GLP-1) plays a vital role in glucose homeostasis and sustaining β-cell function. Currently there are two major methods to enhance endogenous GLP-1 activity; inhibiting dipeptidyl peptidase-4 (DPP4) or activating G p
Externí odkaz:
https://doaj.org/article/b7cf3b9f7d1d47d2a96769334b00ea7b
Publikováno v:
BMC Pharmacology and Toxicology, Vol 18, Iss 1, Pp 1-9 (2017)
Abstract Background E2HSA is a genetic fusion protein that consists of two tandem exendin-4 molecules that are covalently bonded to recombinant human serum albumin via a peptide linker. Previous studies have demonstrated that E2HSA significantly decr
Externí odkaz:
https://doaj.org/article/8b650d24fe014168ac5e1530fd27502d
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 7, Iss 3, Pp 342-346 (2017)
α-Glucosidase and lipase inhibitors play important roles in the treatment of hyperglycaemia and dyslipidemia.To identify novel naturally occurring inhibitors, a bioactivity-guided phytochemical research was performed on the pu-erh tea. One new flava
Externí odkaz:
https://doaj.org/article/78e2e3949d5640918310d53e6ecf7076
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 4, Iss 2, Pp 135-140 (2014)
Dipeptidyl peptidase 4 (DPP4) is recognised as an attractive anti-diabetic drug target, and several DPP4 inhibitors are already on the market. As members of the same gene family, dipeptidyl peptidase 8 (DPP8) and dipeptidyl peptidase 9 (DPP9) share h
Externí odkaz:
https://doaj.org/article/42d719960e0a433bbb44f15cb0dead4c