Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Zhuchi Tu"'
Autor:
Zhuchi Tu, Sen Yan, Bofeng Han, Caijuan Li, Weien Liang, Yingqi Lin, Yongyan Ding, Huiyi Wei, Lu Wang, Hao Xu, Jianmeng Ye, Bang Li, Shihua Li, Xiao-Jiang Li
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 8, Iss 1, Pp 1-13 (2023)
Abstract Tauopathy, characterized by the hyperphosphorylation and accumulation of the microtubule-associated protein tau, and the accumulation of Aβ oligomers, constitute the major pathological hallmarks of Alzheimer’s disease. However, the relati
Externí odkaz:
https://doaj.org/article/8a22c0ceee1f41e1ade340dd7e21cd71
Autor:
Xiao Zheng, Chunhui Huang, Yingqi Lin, Bofeng Han, Yizhi Chen, Caijuan Li, Jiawei Li, Yongyan Ding, Xichen Song, Wei Wang, Weien Liang, Jianhao Wu, Jiaxi Wu, Jiale Gao, Chengxi Wei, Xudong Zhang, Zhuchi Tu, Sen Yan
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 8, Iss 1, Pp 1-13 (2023)
Abstract Severe combined immunodeficiency (SCID) encompasses a range of inherited disorders that lead to a profound deterioration of the immune system. Among the pivotal genes associated with SCID, RAG1 and IL2RG play crucial roles. IL2RG is essentia
Externí odkaz:
https://doaj.org/article/2eba7f6a244f488fb29e7186f8ea325f
Autor:
Bang Li, Hui Zhao, Zhuchi Tu, Weili Yang, Rui Han, Lu Wang, Xiaopeng Luo, Mingtian Pan, Xiusheng Chen, Jiawei Zhang, Huijuan Xu, Xiangyu Guo, Sen Yan, Peng Yin, Zhiguang Zhao, Jianrong Liu, Yafeng Luo, Yuefeng Li, Zhengyi Yang, Baogui Zhang, Zhiqiang Tan, Hao Xu, Tianzi Jiang, Yong-hui Jiang, Shihua Li, Yong Q. Zhang, Xiao-Jiang Li
Publikováno v:
Cell Discovery, Vol 9, Iss 1, Pp 1-23 (2023)
Abstract Autism spectrum disorder (ASD) is a complex neurodevelopmental condition that affects social interaction and behavior. Mutations in the gene encoding chromodomain helicase DNA-binding protein 8 (CHD8) lead to autism symptoms and macrocephaly
Externí odkaz:
https://doaj.org/article/f4a0a5dc3c484d7ab32f386567e0b825
Autor:
Caijuan Li, Yingqi Lin, Yizhi Chen, Xichen Song, Xiao Zheng, Jiawei Li, Jun He, Xiusheng Chen, Chunhui Huang, Wei Wang, Jianhao Wu, Jiaxi Wu, Jiale Gao, Zhuchi Tu, Xiao‐Jiang Li, Sen Yan, Shihua Li
Publikováno v:
Advanced Science, Vol 10, Iss 31, Pp n/a-n/a (2023)
Abstract Accumulation of misfolded proteins leads to many neurodegenerative diseases that can be treated by lowering or removing mutant proteins. Huntington's disease (HD) is characterized by the intracellular accumulation of mutant huntingtin (mHTT)
Externí odkaz:
https://doaj.org/article/78c18d8cc59e4fcd9b2d013316f18d02
Autor:
Yingqi Lin, Caijuan Li, Wei Wang, Jiawei Li, Chunhui Huang, Xiao Zheng, Zhaoming Liu, Xichen Song, Yizhi Chen, Jiale Gao, Jianhao Wu, Jiaxi Wu, Zhuchi Tu, Liangxue Lai, Xiao-Jiang Li, Shihua Li, Sen Yan
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2023)
Animal models are important for understanding the pathogenesis of human diseases and for developing and testing new drugs. Pigs have been widely used in the research on the cardiovascular, skin barrier, gastrointestinal, and central nervous systems a
Externí odkaz:
https://doaj.org/article/2815624c87c84c40a1fa2272997f41bf
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
The foundation for investigating the mechanisms of human diseases is the establishment of animal models, which are also widely used in agricultural industry, pharmaceutical applications, and clinical research. However, small animals such as rodents,
Externí odkaz:
https://doaj.org/article/2afd664ec7734815b154e4d6e92a2b9d
Publikováno v:
Zoological Research; 2024, Vol. 45 Issue 2, p275-283, 9p
Autor:
Sen Yan, Xiao Zheng, Yingqi Lin, Caijuan Li, Zhaoming Liu, Jiawei Li, Zhuchi Tu, Yu Zhao, Chunhui Huang, Yizhi Chen, Jun Li, Xichen Song, Bofeng Han, Wei Wang, Weien Liang, Liangxue Lai, Xiao-Jiang Li, Shihua Li
Publikováno v:
Nature Biomedical Engineering. 7:629-646
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::13e32a28f1b27b56276ad88bc514928c
https://doi.org/10.1038/s41551-023-01007-3
https://doi.org/10.1038/s41551-023-01007-3
Autor:
Yunpeng Zhang, Xiusheng Chen, Xiangyu Guo, Zhuchi Tu, Zhifu Wang, Huida Wan, Xin Xiong, Rui Han, Sen Yan, Xiao-Jiang Li, Yanting Liu, Shihua Li, Lujian Liao, Jifeng Guo, Xianxian Zhao, Peng Yin, Xiao-Xin Yan, Huiming Yang, Xingxing Chen, Qi Wang, Weili Yang
Publikováno v:
Protein & Cell
In vitro studies have established the prevalent theory that the mitochondrial kinase PINK1 protects neurodegeneration by removing damaged mitochondria in Parkinson’s disease (PD). However, difficulty in detecting endogenous PINK1 protein in rodent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac0086d3a4c6eeae4ae1020ff8c98616
https://doi.org/10.1007/s13238-021-00888-x
https://doi.org/10.1007/s13238-021-00888-x
Autor:
Xiao Zheng, Xi-Chen Song, Caijuan Li, Jun Zhang, Zaijun Zhang, Baojian Guo, Zhuchi Tu, Yewei Sun, Bofeng Han, Chunhui Huang, Sen Yan, Yingqi Lin, Guiliang Zhang, Jun Li, Yuqiang Wang
Publikováno v:
Human Molecular Genetics. 30:1484-1496
Amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD) are serious neurodegenerative diseases. Although their pathogenesis is unclear, the abnormal accumulation of TAR DNA-binding protein of 43 kDa (TDP-43) is a pathological
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a179b1d806bf199a5ee41dc703263557
https://doi.org/10.1093/hmg/ddab101
https://doi.org/10.1093/hmg/ddab101