Zobrazeno 1 - 10 of 94 pro vyhledávání: '"Zhuang‐Li Hu"'
1
Akademický článek
Melatonin Ameliorates Depressive‐Like Behaviors in Ovariectomized Mice by Improving Tryptophan Metabolism via Inhibition of Gut Microbe Alistipes Inops
Autor: Kai‐Yu Zheng, Bo Gao, Hua‐Jie Wang, Jin‐Gang He, Hong‐Sheng Chen, Zhuang‐Li Hu, Li‐Hong Long, Jian‐Guo Chen, Fang Wang
Publikováno v: Advanced Science, Vol 11, Iss 34, Pp n/a-n/a (2024)
Abstract Melatonin (N‐acetyl‐5‐methoxytryptamine) is reported to improve mood disorders in perimenopausal women and gut microbiome composition is altered during menopausal period. The possible role of microbiome in the treatment effect of melat
Externí odkaz: https://doaj.org/article/63ef77a8a78444a9a39f09c3bc6d5ed8
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2
Akademický článek
The HMGB1–RAGE axis in nucleus accumbens facilitates cocaine‐induced conditioned place preference via modulating microglial activation
Autor: Jian Ye, Shuang‐Qi Gao, Zi‐Cun Liu, Xi Chen, Jin‐Gang He, Zhuang‐Li Hu
Publikováno v: Brain and Behavior, Vol 14, Iss 3, Pp n/a-n/a (2024)
Abstract Introduction Repeated exposure to cocaine induces microglial activation. Cocaine exposure also induces a release of high mobility group box‐1 (HMGB1) from neurons into the extracellular space in the nucleus accumbens (NAc). HMGB1 is an imp
Externí odkaz: https://doaj.org/article/4a29d66e5bf94adc9494029dce8da7cc
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3
Akademický článek
Cell type-specific NRBF2 orchestrates autophagic flux and adult hippocampal neurogenesis in chronic stress-induced depression
Autor: Shao-Qi Zhang, Qiao Deng, Qi Zhu, Zhuang-Li Hu, Li-Hong Long, Peng-Fei Wu, Jin-Gang He, Hong-Sheng Chen, Zhenyu Yue, Jia-Hong Lu, Fang Wang, Jian-Guo Chen
Publikováno v: Cell Discovery, Vol 9, Iss 1, Pp 1-23 (2023)
Abstract Dysfunctional autophagy and impairment of adult hippocampal neurogenesis (AHN) each contribute to the pathogenesis of major depressive disorder (MDD). However, whether dysfunctional autophagy is linked to aberrant AHN underlying MDD remains
Externí odkaz: https://doaj.org/article/58f02c96d4ad43ee9dd80765316dc3eb
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4
Akademický článek
CD200 in dentate gyrus improves depressive-like behaviors of mice through enhancing hippocampal neurogenesis via alleviation of microglia hyperactivation
Autor: Xi Chen, Qian-Qian Cui, Xiao-Hai Hu, Jian Ye, Zi-Cun Liu, Yuan-Xi Mei, Fang Wang, Zhuang-Li Hu, Jian-Guo Chen
Publikováno v: Journal of Neuroinflammation, Vol 20, Iss 1, Pp 1-19 (2023)
Abstract Background Neuroinflammation and microglia play critical roles in the development of depression. Cluster of differentiation 200 (CD200) is an anti-inflammatory glycoprotein that is mainly expressed in neurons, and its receptor CD200R1 is pri
Externí odkaz: https://doaj.org/article/38e44c83736f4795924507022a86398f
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6
Akademický článek
AMPK Mediates Glucocorticoids Stress-Induced Downregulation of the Glucocorticoid Receptor in Cultured Rat Prefrontal Cortical Astrocytes.
Autor: Shi-Ying Yuan, Jue Liu, Jun Zhou, Wei Lu, Hai-Yun Zhou, Li-Hong Long, Zhuang-Li Hu, Lan Ni, Yi Wang, Jian-Guo Chen, Fang Wang
Publikováno v: PLoS ONE, Vol 11, Iss 8, p e0159513 (2016)
Chronic stress induces altered energy metabolism and plays important roles in the etiology of depression, in which the glucocorticoid negative feedback is disrupted due to imbalanced glucocorticoid receptor (GR) functions. The mechanism underlying th
Externí odkaz: https://doaj.org/article/454aab9d4a6a49d6b1533865f21c5df3
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7
Akademický článek
Orexin-A promotes cell migration in cultured rat astrocytes via Ca2+-dependent PKCα and ERK1/2 signals.
Autor: Qing Shu, Zhuang-Li Hu, Chao Huang, Xiao-Wei Yu, Hua Fan, Jing-Wen Yang, Peng Fang, Lan Ni, Jian-Guo Chen, Fang Wang
Publikováno v: PLoS ONE, Vol 9, Iss 4, p e95259 (2014)
Orexin-A is an important neuropeptide involved in the regulation of feeding, arousal, energy consuming, and reward seeking in the body. The effects of orexin-A have widely studied in neurons but not in astrocytes. Here, we report that OX1R and OX2R a
Externí odkaz: https://doaj.org/article/746cdea108f548f88ad44c8c259208fa
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9
Deficiency of Glycosylated α-Dystroglycan in Ventral Hippocampus Bridges the Destabilization of Gamma-Aminobutyric Acid Type A Receptors With the Depressive-like Behaviors of Male Mice
Autor: Jian-Feng Liu, You Jin, Jian-Guo Chen, Lan Ni, Zhuang-Li Hu, Cong Ma, Jia-Jing Lu, Shi-Ge Xue, Yi Luo, Hui-Ling Zheng, Fang Wang, Wen-Long Xie, Hou-Hong Li
Publikováno v: Biological Psychiatry. 91:593-603
Background Depression is a common psychiatric disorder associated with the defects in GABAergic neurotransmission. α-Dystroglycan (α-DG), a cell adhesion molecule known to be essential for skeletal muscle integrity, is also present at inhibitory sy
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65bcfc421b626f19de39f79b6bc64c6e
https://doi.org/10.1016/j.biopsych.2021.10.022
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10
Microglia-dependent excessive synaptic pruning leads to cortical underconnectivity and behavioral abnormality following chronic social defeat stress in mice
Autor: Ji Wang, Hong-Sheng Chen, Hou-Hong Li, Hua-Jie Wang, Ruo-Si Zou, Xiao-Jia Lu, Jie Wang, Bin-Bin Nie, Jin-Feng Wu, Shuang Li, Bao-Ci Shan, Peng-Fei Wu, Li-Hong Long, Zhuang-Li Hu, Jian-Guo Chen, Fang Wang
Publikováno v: Brain, behavior, and immunity. 109
Synapse loss in medial prefrontal cortex (mPFC) has been implicated in stress-related mood disorders, such as depression. However, the exact effect of synapse elimination in the depression and how it is triggered are largely unknown. Through repeated
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::529185edd2a3e2579d7191c246536dbd
https://pubmed.ncbi.nlm.nih.gov/36581303
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