Výsledky vyhledávání - "Zhu-Wei Ruan"

Akademický článek

Unexpected Enhancement of HDACs Inhibition by MeS Substitution at C-2 Position of Fluoro Largazole

Autor: Bingbing Zhang, Zhu-Wei Ruan, Dongdong Luo, Yueyue Zhu, Tingbo Ding, Qiang Sui, Xinsheng Lei

Publikováno v: Marine Drugs, Vol 18, Iss 7, p 344 (2020)

Given our previous finding that fluorination at the C18 position of largazole showed reasonably good tolerance towards inhibitory activity and selectivity of histone deacetylases (HDACs), further modification on the valine residue in the fluoro-larga

Externí odkaz: https://doaj.org/article/384535cf2d2542babd63c09da14f7b0c

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Akademický článek

Synthesis and Preliminary Biological Evaluation of Two Fluoroolefin Analogs of Largazole Inspired by the Structural Similarity of the Side Chain Unit in Psammaplin A

Autor: Bingbing Zhang, Guangsheng Shan, Yinying Zheng, Xiaolin Yu, Zhu-Wei Ruan, Yang Li, Xinsheng Lei

Publikováno v: Marine Drugs, Vol 17, Iss 6, p 333 (2019)

Largazole, isolated from a marine Cyanobacterium of the genus Symploca, is a potent and selective Class I HDAC (histone deacetylation enzymes) inhibitor. This natural 16-membered macrocyclic depsipeptide features an interesting side chain unit, namel

Externí odkaz: https://doaj.org/article/65f822bd0b954653afc2db346984c02a

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Synthesis and Preliminary Biological Evaluation of Two Fluoroolefin Analogs of Largazole Inspired by the Structural Similarity of the Side Chain Unit in Psammaplin A

Autor: Xiaolin Yu, Zhu-Wei Ruan, Li Yang, Bingbing Zhang, Yinying Zheng, Guangsheng Shan, Xinsheng Lei

Publikováno v: Marine Drugs
Volume 17
Issue 6
Marine Drugs, Vol 17, Iss 6, p 333 (2019)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34cdc878eac6705dffd4a6a4c37a5504

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Unexpected Enhancement of HDACs Inhibition by MeS Substitution at C-2 Position of Fluoro Largazole

Autor: Qiang Sui, Zhu-Wei Ruan, Xinsheng Lei, Bingbing Zhang, Dongdong Luo, Tingbo Ding, Yueyue Zhu

Publikováno v: Marine Drugs; Volume 18; Issue 7; Pages: 344
Marine Drugs, Vol 18, Iss 344, p 344 (2020)
Marine Drugs

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::802ffa10a84da14948a011cf2689f0be
https://doi.org/10.3390/md18070344

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