Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Zhoutao Chen"'
Publikováno v:
PeerJ, Vol 12, p e18050 (2024)
Background Recent advances in long-read sequencing technologies enabled accurate and contiguous de novo assemblies of large genomes and metagenomes. However, even long and accurate high-fidelity (HiFi) reads do not resolve repeats that are longer tha
Externí odkaz:
https://doaj.org/article/ca3965b327204ffd878f0c1a3b5ca87d
Autor:
Veronika Mikhaylova, Madison Rzepka, Tetsuya Kawamura, Yu Xia, Peter L. Chang, Shiguo Zhou, Amber Paasch, Long Pham, Naisarg Modi, Likun Yao, Adrian Perez-Agustin, Sara Pagans, T. Christian Boles, Ming Lei, Yong Wang, Ivan Garcia-Bassets, Zhoutao Chen
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-17 (2024)
Abstract In the human genome, heterozygous sites refer to genomic positions with a different allele or nucleotide variant on the maternal and paternal chromosomes. Resolving these allelic differences by chromosomal copy, also known as phasing, is ach
Externí odkaz:
https://doaj.org/article/b8afd924ceaa4f0296cb028615756b0d
Publikováno v:
Immunity & Ageing, Vol 18, Iss 1, Pp 1-10 (2021)
Abstract Background Studies have shown that the decrease of osteogenic differentiation of bone marrow mesenchymal stem cells (MSC) is an important mechanism of osteoporosis. The object of this study was to explore the role and mechanism of microRNA m
Externí odkaz:
https://doaj.org/article/b3de8c1bec07453eb99ed899b67dd8ae
Autor:
Veronika Mikhaylova, Madison Rzepka, Tetsuya Kawamura, Yu Xia, Peter L. Chang, Shiguo Zhou, Long Pham, Naisarg Modi, Likun Yao, Adrian Perez-Agustin, Sara Pagans, T. Christian Boles, Ming Lei, Yong Wang, Ivan Garcia-Bassets, Zhoutao Chen
In the human genome, heterozygous sites are genomic positions with different alleles inherited from each parent. On average, there is a heterozygous site every 1-2 kilobases (kb). Resolving whether two alleles in neighboring heterozygous positions ar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1ed28ac5173e4b02be474ca366de09aa
https://doi.org/10.1101/2023.03.05.531179
https://doi.org/10.1101/2023.03.05.531179
Autor:
Pedro Belda-Ferre, Long Pham, Yu Xia, Guoya Mo, Zhoutao Chen, Huu Che, Yong Wang, Justin P. Shaffer, Tan Phan, Vikas Bansal, Peter L. Chang, Devin Porter, Wu Tsai-Chin, Ming Lei, Rob Knight, Hao Tran, Greg Humphrey, Son Pham, Pavel A. Pevzner
Publikováno v:
Genome research, vol 30, iss 6
Genome Res
Genome Res
Long-range sequencing information is required for haplotype phasing, de novo assembly, and structural variation detection. Current long-read sequencing technologies can provide valuable long-range information but at a high cost with low accuracy and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::827a89395f2686e457eb7247a29dacb5
https://escholarship.org/uc/item/2645j2bk
https://escholarship.org/uc/item/2645j2bk
Autor:
Zhoutao Chen, Long Pham, Tsai-Chin Wu, Guoya Mo, Yu Xia, Peter L. Chang, Devin Porter, Tan Phan, Huu Che, Hao Tran, Vikas Bansal, Justin Shaffer, Pedro Belda-Ferre, Greg Humphrey, Rob Knight, Pavel Pevzner, Son Pham, Yong Wang, Ming Lei
Publikováno v:
Genome Res
Long-range sequencing information is required for haplotype phasing, de novo assembly, and structural variation detection. Current long-read sequencing technologies can provide valuable long-range information but at a high cost with low accuracy and
Publikováno v:
Bioinformatics
Motivation The recently developed barcoding-based synthetic long read (SLR) technologies have already found many applications in genome assembly and analysis. However, although some new barcoding protocols are emerging and the range of SLR applicatio
Autor:
Fengtang Yang, Jason P. Affourtit, Michael Egholm, Brian C. Godwin, Nigel P. Carter, Bruce E. Taillon, Philip M. Kim, Michael Snyder, Andrea Tanzer, Alexander E. Urban, A. C. Eugenia Saunders, Jan Fredrik Simons, Zhoutao Chen, Sherman M. Weissman, Matthew E. Hurles, Lei Du, Jianxiang Chi, Fabian Grubert, Nicholas Carriero, Jan O. Korbel, Mark Gerstein, Timothy T. Harkins, Dean Palejev
Publikováno v:
Science. 318:420-426
Structural variation of the genome involves kilobase- to megabase-sized deletions, duplications, insertions, inversions, and complex combinations of rearrangements. We introduce high-throughput and massive paired-end mapping (PEM), a large-scale geno
Autor:
Marcel, Margulies, Michael, Egholm, William E, Altman, Said, Attiya, Joel S, Bader, Lisa A, Bemben, Jan, Berka, Michael S, Braverman, Yi-Ju, Chen, Zhoutao, Chen, Scott B, Dewell, Lei, Du, Joseph M, Fierro, Xavier V, Gomes, Brian C, Godwin, Wen, He, Scott, Helgesen, Chun Heen, Ho, Chun He, Ho, Gerard P, Irzyk, Szilveszter C, Jando, Maria L I, Alenquer, Thomas P, Jarvie, Kshama B, Jirage, Jong-Bum, Kim, James R, Knight, Janna R, Lanza, John H, Leamon, Steven M, Lefkowitz, Ming, Lei, Jing, Li, Kenton L, Lohman, Hong, Lu, Vinod B, Makhijani, Keith E, McDade, Michael P, McKenna, Eugene W, Myers, Elizabeth, Nickerson, John R, Nobile, Ramona, Plant, Bernard P, Puc, Michael T, Ronan, George T, Roth, Gary J, Sarkis, Jan Fredrik, Simons, John W, Simpson, Maithreyan, Srinivasan, Karrie R, Tartaro, Alexander, Tomasz, Kari A, Vogt, Greg A, Volkmer, Shally H, Wang, Yong, Wang, Michael P, Weiner, Pengguang, Yu, Richard F, Begley, Jonathan M, Rothberg
Publikováno v:
Nature. 437:376-380
The proliferation of large-scale DNA-sequencing projects in recent years has driven a search for alternative methods to reduce time and cost. Here we describe a scalable, highly parallel sequencing system with raw throughput significantly greater tha
Publikováno v:
International Journal of Developmental Neuroscience. 23:465-474
Patients with severe deficiency of methylenetetrahydrofolate reductase (MTHFR) suffer from a wide variety of neurological problems, which can begin in the neonatal period. MTHFR is a critical enzyme in folate metabolism; the product of the MTHFR reac