Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Zhoushuai Qin"'
Autor:
Xiao-Li Wei, Fenghua Wang, Xiaochen Zhang, Nong Xu, Jie Gao, Xuan Pu, Zhoushuai Qin, Miao Guo, Bin Zhang, Renbin Zhao, Sean Sean Zhang, Rui-hua Xu
Publikováno v:
Journal of Clinical Oncology. 40:3106-3106
3106 Background: NTRK gene fusion resulting from NTRK1/2/3 genetic alterations occurs in various adult and pediatric cancers, which is one of the most defined driving factors of carcinogenesis. Patients with NTRK fusion positive cancers treated by ea
Publikováno v:
The FEBS journal. 286(14)
Rev1, a Y-family DNA polymerase, is involved in the tolerance of DNA damage by translesion DNA synthesis (TLS). Previous studies have shown that the C-terminal domain (CTD) and ubiquitin (Ub)-binding (UBM) domains of Rev1 play important roles in UV-d
Publikováno v:
Apoptosis : an international journal on programmed cell death. 23(1)
Ubiquitination of proliferating cell nuclear antigen (PCNA) plays an important role in DNA damage response. Ectopic expression of PCNA fused at either terminus with ubiquitin (Ub) lacking two C-terminal glycine residues induces translesion DNA synthe
Publikováno v:
Mutation Research/Reviews in Mutation Research. 764:43-50
DNA-damage tolerance (DDT) is an important mechanism for living cells to bypass replication blocks on the template strand. In Saccharomyces cerevisiae, DDT is mediated by the RAD6 epistasis group of genes, consisting of two parallel pathways: error-p
Publikováno v:
The FEBS journal. 284(12)
In eukaryotic cells, Rev7 interacts with Rev3 and functions as a regulatory subunit of Polζ, a translesion DNA synthesis (TLS) polymerase. In addition to its role in TLS, mammalian Rev7, also known as Mad2B/Mad2L2, participates in multiple cellular
Publikováno v:
Nucleic Acids Research
In response to replication-blocking lesions, proliferating cell nuclear antigen (PCNA) can be sequentially ubiquitinated at the K164 residue, leading to two modes of DNA-damage tolerance, namely, translesion DNA synthesis (TLS) and error-free lesion
In response to replication-blocking lesions, proliferating cell nuclear antigen (PCNA) can be sequentially ubiquitinated at the K164 residue leading to 2 modes of DNA-damage tolerance, namely translesion DNA synthesis (TLS) and error-free lesion bypa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3db3db13c54428046309884befc3a809
Publikováno v:
Nucleic Acids Research
It has been long speculated that mammalian Rev3 plays an important, yet unknown role(s) during mammalian development, as deletion of Rev3 causes embryonic lethality in mice, whereas no other translesion DNA synthesis polymerases studied to date are r
Publikováno v:
FEBS letters. 585(18)
Living organisms not only repair DNA damage induced by environmental agents and endogenous cellular metabolites, but have also developed mechanisms to survive in the presence of otherwise lethal lesions. DNA-damage tolerance (DDT) is considered such