Zobrazeno 1 - 10
of 88
pro vyhledávání: '"Zhoumou, Chen"'
Autor:
Timothy M. Doyle, Mark R. Hutchinson, Kathryn Braden, Kali Janes, Vicky Staikopoulos, Zhoumou Chen, William L. Neumann, Sarah Spiegel, Daniela Salvemini
Publikováno v:
Journal of Neuroinflammation, Vol 17, Iss 1, Pp 1-8 (2020)
Abstract Opioid therapies for chronic pain are undermined by many adverse side effects that reduce their efficacy and lead to dependence, abuse, reduced quality of life, and even death. We have recently reported that sphingosine-1-phosphate (S1P) 1 r
Externí odkaz:
https://doaj.org/article/aa30603a92e14637a5ad0de991f3f7b6
Autor:
Kathryn Braden, Michela Campolo, Ying Li, Zhoumou Chen, Timothy M. Doyle, Luigino Antonio Giancotti, Emanuela Esposito, Jinsong Zhang, Salvatore Cuzzocrea, Christopher Kent Arnatt, Daniela Salvemini
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 383:172-181
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9dc09869517c4e9bf8bfd17baa914db0
https://doi.org/10.1124/jpet.122.001283
https://doi.org/10.1124/jpet.122.001283
Autor:
Kyle Oberkrom, Kathryn Braden, Zhoumou Chen, Luigi A. Giancotti, Christopher K. Arnatt, Daniela Salvemini
Publikováno v:
ASPET 2023 Annual Meeting Abstract - Central Nervous System Pharmacology - Behavioral.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bf01759d6b39741d75f4f3bcdde6ec3f
https://doi.org/10.1124/jpet.122.252030
https://doi.org/10.1124/jpet.122.252030
Autor:
Rachel Schafer, Luigi A. Giancotti, Zhoumou Chen, Timothy Doyle, Jinsong Zhang, Daniela Salvemini
Publikováno v:
ASPET 2023 Annual Meeting Abstract - Central Nervous System Pharmacology - Behavioral.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3282f6893479316f8fca634c0215d3aa
https://doi.org/10.1124/jpet.122.244680
https://doi.org/10.1124/jpet.122.244680
Autor:
Zhiwei, Wen, Veronica, Salmaso, Young-Hwan, Jung, Ngan B, Phung, Varun, Gopinatth, Qasim, Shah, Alexandra T, Patterson, John C R, Randle, Zhoumou, Chen, Daniela, Salvemini, David I, Lieberman, Gregory S, Whitehead, Tadeusz P, Karcz, Donald N, Cook, Kenneth A, Jacobson
Publikováno v:
J Med Chem
High affinity phenyl-piperidine P2Y(14)R antagonist 1 (PPTN) was modified with piperidine bridging moieties to probe receptor affinity and hydrophobicity. Various 2-azanorbornane, nortropane, isonortropane, isoquinuclidine, and ring-opened cyclopenty
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::da62c41535c927994c70d1b42266cae7
https://pubmed.ncbi.nlm.nih.gov/35113556
https://pubmed.ncbi.nlm.nih.gov/35113556
Autor:
Kenneth A. Jacobson, Donald N. Cook, Tadeusz P Karcz, John C R Randle, John M. Bennett, Varun Gopinatth, Zhiwei Wen, Ngan B. Phung, Daniela Salvemini, Young-Hwan Jung, David I. Lieberman, Veronica Salmaso, Zhoumou Chen
Publikováno v:
Journal of Medicinal Chemistry. 64:5099-5122
A known zwitterionic, heterocyclic P2Y14R antagonist 3a was substituted with diverse groups on the central phenyl and terminal piperidine moieties, following a computational selection process. The most potent analogues contained an uncharged piperidi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8619de0d7c2d74a8325f516dd55228e
https://doi.org/10.1021/acs.jmedchem.1c00164
https://doi.org/10.1021/acs.jmedchem.1c00164
Autor:
Kathryn Braden, Michela Campolo, Zhoumou Chen, Luigi Giancotti, Timothy M. Doyle, Emanuela Esposito, Jinsong Zhang, Salvatore Cuzzocrea, Christopher K. Arnatt, Daniela Salvemini
Publikováno v:
The FASEB Journal. 36
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9845d66aaeb7d7fbfb7b536a1d13476f
https://doi.org/10.1096/fasebj.2022.36.s1.r2071
https://doi.org/10.1096/fasebj.2022.36.s1.r2071
Autor:
Fatma Mufti, Young‐Hwan Jung, Luigino A. Giancotti, Jinha Yu, Zhoumou Chen, Ngan B. Phung, Kenneth A. Jacobson, Daniela Salvemini
Publikováno v:
The FASEB Journal. 36
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3defa1d8be263e0c4f0ba2477d633fa5
https://doi.org/10.1096/fasebj.2022.36.s1.r2874
https://doi.org/10.1096/fasebj.2022.36.s1.r2874
Autor:
Yaron Rotman, Kenneth A. Jacobson, Maren C. Podszun, Daniela Salvemini, R. Rama Suresh, Shanu Jain, Yanling Ma, Dilip K. Tosh, Zhoumou Chen
Publikováno v:
Purinergic Signalling. 16:367-377
Prodrugs (MRS7422, MRS7476) of highly selective A3 adenosine receptor (AR) agonists Cl-IB-MECA and MRS5698, respectively, were synthesized by succinylation of the 2′ and 3′ hydroxyl groups, and the parent, active drug was shown to be readily libe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::571f40ab3771c56e2a900a32d3fc00dc
https://doi.org/10.1007/s11302-020-09715-0
https://doi.org/10.1007/s11302-020-09715-0
Autor:
Zhoumou Chen, Kenneth A. Jacobson, Vasiliki Staikopoulos, Todd W Vanderah, Gary J. Bennett, Dilip K. Tosh, Rebecca Dalgarno, Daniela Salvemini, Tuan Trang, Mark R. Hutchinson, Churmy Fan, Timothy M. Doyle, Salvatore Cuzzocrea, Emanuela Esposito, Tally M. Largent-Milnes
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 374:331-341
Treating chronic pain using opioids, such as morphine, is hampered by the development of opioid-induced hyperalgesia (OIH; increased pain sensitivity), antinociceptive tolerance and withdrawal which can contribute to dependence and abuse. In the cent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78e5c72de91dfcafafb9456e74601105
https://doi.org/10.1124/jpet.120.000004
https://doi.org/10.1124/jpet.120.000004