Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Zhouliang Chen"'
Publikováno v:
Fuzzy Sets and Systems. 462:108453
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b5b2f8e3da4dc10f1b7b49b99b6392fe
https://doi.org/10.1016/j.fss.2022.12.009
https://doi.org/10.1016/j.fss.2022.12.009
Autor:
Victoriano Tamez, Brant Firestone, Michelle Fodor, Martin Sendzik, Michael G. Acker, Stan Spence, Matthew J. LaMarche, Mitsunori Kato, Chen Liu, Christopher Towler, Ping Wang, Ho Man Chan, Eric McNeill, Shumei Liu, Morvarid Mohseni, Sarah Williams, Zhouliang Chen, Gang Liu, Bing Yu, Robert Koenig, Huaixiang Hao, Ying-Nan Chen, Murphy Hentemann, Ritesh Bhanudasji Tichkule, Hongyun Wang, Jorge Garcia Fortanet, Laura R. LaBonte, Jeffrey T. Bagdanoff, Travis Stams, Patrick James Sarver
Publikováno v:
Journal of Medicinal Chemistry. 62:1793-1802
Protein tyrosine phosphatase SHP2 is an oncoprotein associated with cancer as well as a potential immune modulator because of its role in the programmed cell death PD-L1/PD-1 pathway. In the preceding manuscript, we described the optimization of a fu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a24d74ccebe527aac56b75855102ac3c
https://doi.org/10.1021/acs.jmedchem.8b01726
https://doi.org/10.1021/acs.jmedchem.8b01726
Autor:
Kelly Slocum, Jianmei Fan, Michael Dore, Palermo Mark G, Zhan Deng, Bakary-Barry Toure, Jorge Garcia-Fortanet, Dyuti Majumdar, Martin F. Hentemann, Nick Keen, Suzanne Zhu, Christopher Towler, Michael Shultz, William R. Sellers, Simon Mathieu, Denise Grunenfelder, Robert Koenig, Douglas C. Bauer, Shumei Liu, Jay Larrow, Victoriano Tamez, David Dunstan, Andreea Argintaru, Timothy Michael Ramsey, Zhouliang Chen, Gang Liu, Ying-Nan Chen, Rukundo Ntaganda, Bing Yu, Joanna Slisz, Hongyun Wang, Pascal D. Fortin, Christopher Sean Straub, Ji-Hu Zhang, Ping Wang, Laura R. LaBonte, Mitsunori Kato, Matthew J. Meyer, Fan Yang, Patrick James Sarver, Samuel B. Ho, Brant Firestone, Rajesh Karki, John F. Reilly, Troy Smith, Ho Man Chan, Cary Fridrich, John William Giraldes, Julie Boisclair, Chen Christine Hiu-Tung, Meir Glick, Zhao B. Kang, Morvarid Mohseni, Lawrence Blas Perez, Michael G. Acker, Sarah Williams, Matthew J. LaMarche, Martin Sendzik, Michelle Fodor, Huia-Xiang Hao, Peter Fekkes, Minying Pu, Travis Stams, Stanley Spence, Andriana Jouk
Publikováno v:
Journal of medicinal chemistry. 63(22)
SHP2 is a nonreceptor protein tyrosine phosphatase encoded by the PTPN11 gene and is involved in cell growth and differentiation via the MAPK signaling pathway. SHP2 also plays an important role in the programed cell death pathway (PD-1/PD-L1). As an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::345804676325a445ebbb9ef600ced79a
https://pubmed.ncbi.nlm.nih.gov/32910655
https://pubmed.ncbi.nlm.nih.gov/32910655
Autor:
Zhinong Li, Zhouliang Chen
Publikováno v:
Journal of Intelligent & Fuzzy Systems. 34:3443-3449
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e5fee991183bab4fea7e0b87fd50cb78
https://doi.org/10.3233/jifs-169524
https://doi.org/10.3233/jifs-169524
Autor:
Christopher Towler, Andriana Jouk, Murphy Hentemann, Matthew J. LaMarche, Bing Yu, Jorge Garcia Fortanet, Michelle Fodor, Hongyun Wang, Sarah Williams, Morvarid Mohseni, Shumei Liu, Huaixiang Hao, Ritesh Bhanudasji Tichkule, Ying-Nan Chen, Chen Liu, Ping Wang, Patrick James Sarver, Stan Spence, Laura R. LaBonte, Jeffrey T. Bagdanoff, Brant Firestone, Michael Shultz, Martin Sendzik, Eric McNeill, Zhouliang Chen, Gang Liu, Victoriano Tamez, Robert Koenig, Michael G. Acker, Ho Man Chan, Travis Stams, Mitsunori Kato
Publikováno v:
Journal of medicinal chemistry. 62(7)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::385537f7a24ba5be8ef7298e05ce98f5
https://pubmed.ncbi.nlm.nih.gov/30688459
https://pubmed.ncbi.nlm.nih.gov/30688459
Autor:
Michael G. Acker, Ping Wang, Brant Firestone, Ying-Nan Chen, Shumei Liu, Jorge Garcia Fortanet, Michael Shultz, Robert Koenig, Ho Man Chan, Mitsunori Kato, Murphy Hentemann, Rukundo Ntaganda, Patrick James Sarver, Laura R. LaBonte, Martin Sendzik, Jeffrey T. Bagdanoff, Zhouliang Chen, Michelle Fodor, Movarid Mohseni, Travis Stams, Christopher Towler, Troy Smith, Stan Spence, Hongyun Wang, Matthew J. LaMarche, Michael Dore, Sarah Williams
Publikováno v:
Journal of medicinal chemistry. 62(7)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c41b30051a63a647dd7bbd399e7f584
https://pubmed.ncbi.nlm.nih.gov/30688462
https://pubmed.ncbi.nlm.nih.gov/30688462
Autor:
Movarid Mohseni, Michelle Fodor, Jorge Garcia Fortanet, Shumei Liu, Laura R. LaBonte, Rukundo Ntaganda, Jeffrey T. Bagdanoff, Sarah Williams, Robert Koenig, Travis Stams, Ho Man Chan, Michael Dore, Christopher Towler, Matthew J. LaMarche, Brant Firestone, Ping Wang, Troy Smith, Michael G. Acker, Murphy Hentemann, Ying-Nan Chen, Patrick James Sarver, Hongyun Wang, Stan Spence, Martin Sendzik, Mitsunori Kato, Zhouliang Chen
Publikováno v:
Journal of medicinal chemistry. 62(4)
SHP2 is a nonreceptor protein tyrosine phosphatase within the mitogen-activated protein kinase (MAPK) pathway controlling cell growth, differentiation, and oncogenic transformation. SHP2 also participates in the programed cell death pathway (PD-1/PD-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45eafbfd047a160231872f5fdd05d6ed
https://pubmed.ncbi.nlm.nih.gov/30900881
https://pubmed.ncbi.nlm.nih.gov/30900881
Publikováno v:
Journal of Environmental Chemical Engineering. 9:104655
Fluoride contamination in water continues to be a great challenge to the sustainable development of global fluorine-containing industries. It is still a challenge to avoid the use of chemical desorbents induced secondary contamination in regenerating
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::95f3fad8641f2f7c1dc7c71dad24ccf6
https://doi.org/10.1016/j.jece.2020.104655
https://doi.org/10.1016/j.jece.2020.104655
Autor:
Matthew J. LaMarche, Peter Fekkes, Jorge Garcia Fortanet, Michael Shultz, Denise Grunenfelder, Zhouliang Chen, Gang Liu, Chen Christine Hiu-Tung, Minying Pu, Travis Stams, Pascal D. Fortin, Palermo Mark G, Ping Wang, Samuel B. Ho, Brant Firestone, Matthew J. Meyer, Dyuti Majumdar, Laura R. LaBonte, Francois Lenoir, Rajesh Karki, Nick Keen, Cary Fridrich, Michelle Fodor, Jay Larrow, Sarah Williams, Christopher Towler, Timothy Michael Ramsey, Ji-Hu Zhang, Franco Lombardo, Ying-Nan P. Chen, Zhan Deng, Mitsunori Kato, Zhao B. Kang, Lawrence Blas Perez, Shumei Liu, William R. Sellers
Publikováno v:
Journal of Medicinal Chemistry. 59:7773-7782
SHP2 is a nonreceptor protein tyrosine phosphatase (PTP) encoded by the PTPN11 gene involved in cell growth and differentiation via the MAPK signaling pathway. SHP2 also purportedly plays an important role in the programmed cell death pathway (PD-1/P
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dab8364be893583bdc1d3f32d1e22004
https://doi.org/10.1021/acs.jmedchem.6b00680
https://doi.org/10.1021/acs.jmedchem.6b00680
Autor:
Palermo Mark G, Timothy Michael Ramsey, Ping Zhu, Shumei Liu, Jay Larrow, Laura R. La Bonte, Rajesh Karki, Chen Christine Hiu-Tung, Kavitha Venkatesan, Jaison Jacob, Pascal D. Fortin, Francois Lenoir, Hui Gao, Guizhi Yang, Matthew J. Meyer, Ji-Hu Zhang, William R. Sellers, Michael Shultz, Denise Grunenfelder, Edmund Price, Jorge Garcia-Fortanet, Feng Fei, Zhouliang Chen, Gang Liu, Vesselina G. Cooke, Jing Yuan, Michelle Fodor, Ping Wang, Minying Pu, Nicholas Keen, Samuel B. Ho, Kathy Hsiao, Markus Warmuth, Travis Stams, Christopher Quinn, Mitsunori Kato, Subarna Shakya, Sarah Williams, Dyuti Majumdar, Peter Fekkes, Michael G. Acker, Cary Fridrich, Joanna Slisz, Huaixiang Hao, Matthew J. LaMarche, Ying-Nan P. Chen, Brandon Antonakos, Jason R. Dobson, Brant Firestone, Lawrence Blas Perez, Zhao B. Kang, Ho Man Chan, Zhan Deng
Publikováno v:
Nature. 535:148-152
SHP099, a selective inhibitor of signalling meditator SHP2 with drug-like properties, has an allosteric mechanism of action whereby it stabilizes SHP2 in an auto-inhibited conformation, and suppresses RAS–ERK signalling and proliferation in recepto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f58ee0fa5f3f5109027ba2125d369122
https://doi.org/10.1038/nature18621
https://doi.org/10.1038/nature18621