Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Zhoukang Zhuang"'
Autor:
Zhoukang Zhuang, Wenping Kong, Zhongqing Wen, Nian Tong, Jing Lin, Fan Zhang, Zhiying Fan, Liwei Yi, Yong Huang, Yanwen Duan, Xiaohui Yan, Xiangcheng Zhu
Publikováno v:
Microbial Cell Factories, Vol 23, Iss 1, Pp 1-13 (2024)
Abstract Background Anthraquinone-fused enediynes (AFEs) are excellent payloads for antibody-drug conjugates (ADCs). The yields of AFEs in the original bacterial hosts are extremely low. Multiple traditional methods had been adopted to enhance the pr
Externí odkaz:
https://doaj.org/article/f308de08a1c74e6889ca58ff96e8b3c3
Autor:
Jian Pan, Qingwen Tan, Saibin Zhu, Xiaohui Yan, Yu Li, Zhoukang Zhuang, Xiangcheng Zhu, Yanwen Duan, Yong Huang
Publikováno v:
Chemical Science. 13:13475-13481
The identification and characterization of enediyne polyketide synthases (PKSEs) revealed that PKSE-bound polyene is a common intermediate, while its subsequent tailoring steps to enediyne cores remain obscure. Herein, we report pentaene polyols 5-7
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82d94b69a1c8d5d52e24c665c526455b
https://doi.org/10.1039/d2sc04379c
https://doi.org/10.1039/d2sc04379c
Publikováno v:
ACS Synthetic Biology. 9:1460-1467
The complex life cycle of streptomycetes is closely related to their secondary metabolisms, all controlled by cascade regulations. Tiancimycins (TNMs) are ten-membered enediynes possessing great potential for antitumor drug development. However, thei
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::84876fd2a02b7beacc60998a6052b301
https://doi.org/10.1021/acssynbio.0c00114
https://doi.org/10.1021/acssynbio.0c00114
Autor:
Xiangcheng Zhu, Ling Liu, Yong Huang, Jing Lin, Wenping Kong, Huiming Liu, Zhoukang Zhuang, Chengzhou Jiang, Yanwen Duan
Publikováno v:
Applied Microbiology and Biotechnology. 104:4359-4369
Tiancimycin-A (TNM-A) is an anthraquinone-fused ten-membered enediyne produced by Streptomyces sp. CB03234, which is very promising for the development of anticancer antibody-drug conjugates (ADCs). To improve the titer of TNM-A, we have generated hi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4668e23e1f0ee03f9c0d0ba8de5eab6
https://doi.org/10.1007/s00253-020-10583-2
https://doi.org/10.1007/s00253-020-10583-2
Autor:
Zhiying Fan, Nian Tong, Zhoukang Zhuang, Cheng Ma, Junying Ma, Jianhua Ju, Yanwen Duan, Xiangcheng Zhu
Tuberculosis (TB) and its emerged drug resistance exert huge threats on the global health, therefore development of novel anti-TB antibiotics is very essential. Ilamycin-E1/E2 is a pair of cycloheptapeptide enantiomers obtained from a marine-derived
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::67a8be5cc836512431a73c5ffcb70e6f
https://doi.org/10.22541/au.163251246.65100311/v1
https://doi.org/10.22541/au.163251246.65100311/v1
Autor:
Fan Zhang, Yong Huang, Yanwen Duan, Liwei Yi, Xiangcheng Zhu, Xiaohui Yan, Chengzhou Jiang, Rong Huang, Zhoukang Zhuang
Publikováno v:
Biotechnology and Bioengineering. 116:1304-1314
Tiancimycins (TNMs) are a group of 10-membered anthraquinone-fused enediynes, newly discovered from Streptomyces sp. CB03234. Among them, TNM-A and TNM-D have exhibited excellent antitumor performances and could be exploited as very promising warhead
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f5c514032c9f78d35f23712fcc6a3c4
https://doi.org/10.1002/bit.26944
https://doi.org/10.1002/bit.26944
Autor:
Fan, Zhang, Die, Gao, Jing, Lin, Manxiang, Zhu, Zhoukang, Zhuang, Yanwen, Duan, Xiangcheng, Zhu
Publikováno v:
ACS synthetic biology. 9(6)
The complex life cycle of streptomycetes is closely related to their secondary metabolisms, all controlled by cascade regulations. Tiancimycins (TNMs) are ten-membered enediynes possessing great potential for antitumor drug development. However, thei
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::86f8e3c3156bbd4ef3484cb782e2a5df
https://pubmed.ncbi.nlm.nih.gov/32379959
https://pubmed.ncbi.nlm.nih.gov/32379959
Autor:
Zhuang, Zhoukang1 (AUTHOR), Kong, Wenping1 (AUTHOR), Wen, Zhongqing1 (AUTHOR), Tong, Nian1 (AUTHOR), Lin, Jing1 (AUTHOR), Zhang, Fan1 (AUTHOR), Fan, Zhiying1 (AUTHOR), Yi, Liwei1,2 (AUTHOR), Huang, Yong1,3 (AUTHOR), Duan, Yanwen1,3,4 (AUTHOR) ywduan66@sina.com, Yan, Xiaohui1,5 (AUTHOR) yanxh@tjutcm.edu.cn, Zhu, Xiangcheng1,3,4 (AUTHOR) seanzhu1996@aliyun.com
Publikováno v:
Microbial Cell Factories. 5/4/2024, Vol. 23 Issue 1, p1-13. 13p.
Autor:
Liu, Huiming1 (AUTHOR), Jiang, Chengzhou1 (AUTHOR), Lin, Jing1 (AUTHOR), Zhuang, Zhoukang1 (AUTHOR), Kong, Wenping1 (AUTHOR), Liu, Ling1 (AUTHOR), Huang, Yong1,2 (AUTHOR), Duan, Yanwen1,2,3 (AUTHOR) ywduan66@sina.com, Zhu, Xiangcheng1,2,3 (AUTHOR) seanzhu1996@aliyun.com
Publikováno v:
Applied Microbiology & Biotechnology. May2020, Vol. 104 Issue 10, p4359-4369. 11p.
Publikováno v:
Chemical Science; 12/7/2022, Vol. 13 Issue 45, p13253-13263, 11p