Network Pharmacology-based Research of Active Components of Albiziae Flos and Mechanisms of Its Antidepressant Effect

Autor: Xiong Yiyi, Zhou-Tao Xie, Song-Tao Wu, Xiong Weichen, Wu Hezhen, Yunfeng Yao, Yang Yanfang, Bo Liu

Publikováno v: Current Medical Science. 40:123-129

Albiziae Flos (AF) has been experimentally proven to have an antidepressant effect. However, due to the complexity of botanical ingredients, the exact pharmacological mechanism of action of AF in depression has not been completely deciphered. This st

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b623ef374187dd4cbbcc20426edf8294
https://doi.org/10.1007/s11596-020-2155-7

Reveals of candidate active ingredients in Justicia and its anti-thrombotic action of mechanism based on network pharmacology approach and experimental validation

Autor: Ting Zhang, Ying Zhang, Hezhen Wu, Lu Yi, Yunfeng Yao, Yanfang Yang, Zongchao Hong, Bo Liu, Zhou-Tao Xie

Publikováno v: Scientific Reports, Vol 11, Iss 1, Pp 1-18 (2021)
Scientific Reports

Thrombotic diseases seriously threaten human life. Justicia, as a common Chinese medicine, is usually used for anti-inflammatory treatment, and further studies have found that it has an inhibitory effect on platelet aggregation. Therefore, it can be

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44487682277d89493925bfab071cec75
https://doi.org/10.1038/s41598-021-96683-z

A novel anti-platelet aggregation target of chinensinaphthol methyl ether and neojusticin B obtained from Rostellularia procumbens (L.) Nees

Autor: Bo Liu, Wen-Ping Xiao, Hao Pengfei, Song-Tao Wu, Sun Yuan, Zhongzhu Ai, Xiong Weichen, Yanfang Yang, Hezhen Wu, Zhou-Tao Xie

Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 34, Iss 1, Pp 999-1009 (2019)
Journal of Enzyme Inhibition and Medicinal Chemistry

This study explored the possible bioactive ingredients and target protein of Rostellularia procumbens (L.) Nees. The results of optical turbidimetry revealed that the ethyl acetate extraction obtained from R. procumbens (L.) Nees could inhibit platel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eeea1adfacf2d1108838f8e47cb9ed50
https://doaj.org/article/8fe23ca51a3c495794810a6b6bacc3ed

Active Ingredients and Mechanism of Action of Rhizoma Coptidis against Type 2 Diabetes Based on Network-Pharmacology and Bioinformatics

Autor: Wu Hezhen, Bi-Sheng Huang, Yang Yanfang, Zhou-Tao Xie, Xiong Yiyi, Xiong Weichen, Wen-Ping Xiao, Bo Liu, Sun Yuan

Publikováno v: Current medical science. 40(2)

A pharmacological network of "component/target/pathway" for Rhizoma coptidis against type 2 diabetes (T2D) was established by network-pharmacology, and the active components of Rhizoma coptidis and its mechanism were explored. A literature-based and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::beed5fc697b6c708cf786f796af69383
https://pubmed.ncbi.nlm.nih.gov/32337687

[Studies on the chemical constituents in ethyl acetate extraction from the fruit of Polygonum orientale]

Autor: Zhou-tao, Xie, Jin, Hu

Publikováno v: Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials. 32(9)

To study on the chemical constituents in ethyl acetate extraction from Polygonum orientale.By repeated silica gel chromatographic seperation and spectral analysis the structures were determined.Seven compounds were isolated and identified from Polygo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e5b77c7939be5e5c3db92514b10d1f5e
https://pubmed.ncbi.nlm.nih.gov/20034216