Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Zhou-Qin Zheng"'
Autor:
Wei-Wei Luo, Zhen Tong, Pan Cao, Fu-Bing Wang, Ying Liu, Zhou-Qin Zheng, Su-Yun Wang, Shu Li, Yan-Yi Wang
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
The transcription factor IRF8 has been shown to regulate monocyte differentiation via its DNA-binding activity. Here authors show that IRF8 is also involved in cytosolic DNA sensing via its phosphorylation-dependent association to the adaptor protein
Externí odkaz:
https://doaj.org/article/2f7cce334ca742d9bbb81e7290a22a5d
Publikováno v:
Cell Discovery, Vol 7, Iss 1, Pp 1-11 (2021)
Abstract The newly emerging coronavirus SARS-CoV-2 causes severe lung disease and substantial mortality. How the virus evades host defense for efficient replication is not fully understood. In this report, we found that the SARS-CoV-2 nucleocapsid pr
Externí odkaz:
https://doaj.org/article/632c797bc210429ea21d9b702364a008
Publikováno v:
Cell Insight, Vol 1, Iss 2, Pp 100014- (2022)
After herpes simplex virus type 1 (HSV-1) infection, the cytosolic sensor cyclic GMP-AMP synthase (cGAS) recognizes DNA and catalyzes synthesis of the second messenger 2′3′-cGAMP. cGAMP binds to the ER-localized adaptor protein MITA (also known a
Externí odkaz:
https://doaj.org/article/fcb8742a208d4c82becae0bdf1e0a522
Publikováno v:
PLoS Pathogens, Vol 15, Iss 8, p e1007983 (2019)
Recognition of viral RNA by the retinoic acid-inducible gene-I (RIG-I)-like receptors (RLRs), including RIG-I and MDA5, initiates innate antiviral responses. Although regulation of RLR-mediated signal transduction has been extensively investigated, h
Externí odkaz:
https://doaj.org/article/748dc750c5814d4a8f522c872d40363a
Autor:
Wei-Wei Luo, Shu Li, Chen Li, Zhou-Qin Zheng, Pan Cao, Zhen Tong, Huan Lian, Su-Yun Wang, Hong-Bing Shu, Yan-Yi Wang
Publikováno v:
PLoS Pathogens, Vol 13, Iss 11, p e1006693 (2017)
VISA (also known as MAVS, IPS-1 and Cardif) is an essential adaptor protein in innate immune response to RNA virus. The protein level of VISA is delicately regulated before and after viral infection to ensure the optimal activation and timely termina
Externí odkaz:
https://doaj.org/article/54d6e574e1f64ac3978585752587e7a3
Publikováno v:
Cell Discovery, Vol 7, Iss 1, Pp 1-11 (2021)
Cell Discovery
Cell Discovery
The newly emerging coronavirus SARS-CoV-2 causes severe lung disease and substantial mortality. How the virus evades host defense for efficient replication is not fully understood. In this report, we found that the SARS-CoV-2 nucleocapsid protein (NP
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f80704054452c7801787e9b8789c5143
https://doaj.org/article/632c797bc210429ea21d9b702364a008
https://doaj.org/article/632c797bc210429ea21d9b702364a008
Autor:
Wei-Wei Luo, Zhen Tong, Pan Cao, Fu-Bing Wang, Ying Liu, Zhou-Qin Zheng, Su-Yun Wang, Shu Li, Yan-Yi Wang
Publikováno v:
Nature communications. 13(1)
Sensing of cytosolic DNA of microbial or cellular/mitochondrial origin by cGAS initiates innate immune responses via the adaptor protein STING. It remains unresolved how the activity of STING is balanced between a productive innate immune response an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20ccf9de57c2114662757fcad7d3a1f9
https://pubmed.ncbi.nlm.nih.gov/35973990
https://pubmed.ncbi.nlm.nih.gov/35973990
Publikováno v:
Cellular & Molecular Immunology
Cellular and Molecular Immunology
Cellular and Molecular Immunology
A novel SARS-related coronavirus (SARS-CoV-2) has recently emerged as a serious pathogen that causes high morbidity and substantial mortality. However, the mechanisms by which SARS-CoV-2 evades host immunity remain poorly understood. Here, we identif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15e9f18eea328fafb25037e87302a8d9
Publikováno v:
PLoS Pathogens
PLoS Pathogens, Vol 15, Iss 8, p e1007983 (2019)
PLoS Pathogens, Vol 15, Iss 8, p e1007983 (2019)
Recognition of viral RNA by the retinoic acid-inducible gene-I (RIG-I)-like receptors (RLRs), including RIG-I and MDA5, initiates innate antiviral responses. Although regulation of RLR-mediated signal transduction has been extensively investigated, h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::848ea10b259c1cfb4d5adbf0e171dd36
http://europepmc.org/articles/PMC6703689
http://europepmc.org/articles/PMC6703689
Autor:
Huan Lian, Pan Cao, Wei-Wei Luo, Zhou-Qin Zheng, Shu Li, Yan-Yi Wang, Chen Li, Hong-Bing Shu, Su-Yun Wang, Zhen Tong
Publikováno v:
PLoS Pathogens, Vol 13, Iss 11, p e1006693 (2017)
PLoS Pathogens
PLoS Pathogens
VISA (also known as MAVS, IPS-1 and Cardif) is an essential adaptor protein in innate immune response to RNA virus. The protein level of VISA is delicately regulated before and after viral infection to ensure the optimal activation and timely termina
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8b9ffaef2f12fa22b2480eee6858458
https://doi.org/10.1371/journal.ppat.1006693
https://doi.org/10.1371/journal.ppat.1006693