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Sequentially sustained release of anticarcinogens for postsurgical chemoimmunotherapy

Autor: Chen, Qian, Li, Yanan, Zhou, Shuai, Chen, Dali, Zhou, Muye, Chen, Qinying, Lu, Yuren, Cai, Naicong, Liu, Can, Guo, Yumeng, Qiu, Zijie, Hou, Xiaoyan, Tu, Jiasheng, Shen, Weiyang, Sun, Chunmeng

Publikováno v: In Journal of Controlled Release October 2022 350:803-814

Combinatorial design of ionizable lipid nanoparticles for muscle-selective mRNA delivery with minimized off-target effects.

Autor: Chen J; Institute of Biomedical Engineering, University of Toronto, Toronto, ON M5S 3G9, Canada., Xu Y; Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, ON M5S 3M2, Canada., Zhou M; Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, ON M5S 3M2, Canada., Xu S; Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, ON M5S 3M2, Canada., Varley AJ; Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, ON M5S 3M2, Canada., Golubovic A; Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, ON M5S 3M2, Canada., Lu RXZ; Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, ON M5S 3M2, Canada., Wang KC; Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, ON M5S 3M2, Canada., Yeganeh M; Institute of Medical Science, University of Toronto, Toronto, ON M5G 1L7, Canada., Vosoughi D; Institute of Medical Science, University of Toronto, Toronto, ON M5G 1L7, Canada.; Latner Thoracic Laboratories, Toronto General Hospital Research Institute, University Health Network, Toronto, ON M5G 2C4, Canada., Li B; Institute of Biomedical Engineering, University of Toronto, Toronto, ON M5S 3G9, Canada.; Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, ON M5S 3M2, Canada.; Princess Margaret Cancer Center, University Health Network, Toronto, ON M5G 2C1, Canada.

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2023 Dec 12; Vol. 120 (50), pp. e2309472120. Date of Electronic Publication: 2023 Dec 07.