Zobrazeno 1 - 10
of 103
pro vyhledávání: '"Zhongyuan Zuo"'
Autor:
Jenny Zhe Liao, Hyung-lok Chung, Claire Shih, Kenneth Kin Lam Wong, Debdeep Dutta, Zelha Nil, Catherine Grace Burns, Oguz Kanca, Ye-Jin Park, Zhongyuan Zuo, Paul C. Marcogliese, Katherine Sew, Hugo J. Bellen, Esther M. Verheyen
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract Cdk8 in Drosophila is the orthologue of vertebrate CDK8 and CDK19. These proteins have been shown to modulate transcriptional control by RNA polymerase II. We found that neuronal loss of Cdk8 severely reduces fly lifespan and causes bang sen
Externí odkaz:
https://doaj.org/article/09c78393720044e6a04bcc50ab0689d0
Autor:
Guang Lin, Burak Tepe, Geoff McGrane, Regine C Tipon, Gist Croft, Leena Panwala, Amanda Hope, Agnes JH Liang, Zhongyuan Zuo, Seul Kee Byeon, Lily Wang, Akhilesh Pandey, Hugo J Bellen
Publikováno v:
eLife, Vol 12 (2023)
Infantile neuroaxonal dystrophy (INAD) is caused by recessive variants in PLA2G6 and is a lethal pediatric neurodegenerative disorder. Loss of the Drosophila homolog of PLA2G6, leads to ceramide accumulation, lysosome expansion, and mitochondrial def
Externí odkaz:
https://doaj.org/article/e4633d77eb604aa29a4117eee3456289
Autor:
Justin A Bosch, Berrak Ugur, Israel Pichardo-Casas, Jordan Rabasco, Felipe Escobedo, Zhongyuan Zuo, Ben Brown, Susan Celniker, David A Sinclair, Hugo J Bellen, Norbert Perrimon
Publikováno v:
eLife, Vol 11 (2022)
Naturally produced peptides (
Externí odkaz:
https://doaj.org/article/6549c99e7d9d4f4292fd9b2eb3a57f4b
Autor:
Oguz Kanca, Jonathan Zirin, Yanhui Hu, Burak Tepe, Debdeep Dutta, Wen-Wen Lin, Liwen Ma, Ming Ge, Zhongyuan Zuo, Lu-Ping Liu, Robert W Levis, Norbert Perrimon, Hugo J Bellen
Publikováno v:
eLife, Vol 11 (2022)
Previously, we described a large collection of Drosophila strains that each carry an artificial exon containing a T2AGAL4 cassette inserted in an intron of a target gene based on CRISPR-mediated homologous recombination. These alleles permit numerous
Externí odkaz:
https://doaj.org/article/21349c0042e4440c9ed944c980a33c8b
Autor:
Felipe Martelli, Natalia H Hernandes, Zhongyuan Zuo, Julia Wang, Ching-On Wong, Nicholas E Karagas, Ute Roessner, Thusita Rupasinghe, Charles Robin, Kartik Venkatachalam, Trent Perry, Philip Batterham, Hugo J Bellen
Publikováno v:
eLife, Vol 11 (2022)
Large-scale insecticide application is a primary weapon in the control of insect pests in agriculture. However, a growing body of evidence indicates that it is contributing to the global decline in population sizes of many beneficial insect species.
Externí odkaz:
https://doaj.org/article/51846748db3143c4a3631663c675f04a
Autor:
Kathleen M Cunningham, Kirstin Maulding, Kai Ruan, Mumine Senturk, Jonathan C Grima, Hyun Sung, Zhongyuan Zuo, Helen Song, Junli Gao, Sandeep Dubey, Jeffrey D Rothstein, Ke Zhang, Hugo J Bellen, Thomas E Lloyd
Publikováno v:
eLife, Vol 9 (2020)
Disrupted nucleocytoplasmic transport (NCT) has been implicated in neurodegenerative disease pathogenesis; however, the mechanisms by which disrupted NCT causes neurodegeneration remain unclear. In a Drosophila screen, we identified ref(2)P/p62, a ke
Externí odkaz:
https://doaj.org/article/1a36dcfe2f884b73b4686aa681abb4ea
Autor:
Hui Ye, Shamsideen A Ojelade, David Li-Kroeger, Zhongyuan Zuo, Liping Wang, Yarong Li, Jessica YJ Gu, Ulrich Tepass, Avital Adah Rodal, Hugo J Bellen, Joshua M Shulman
Publikováno v:
eLife, Vol 9 (2020)
Retromer, including Vps35, Vps26, and Vps29, is a protein complex responsible for recycling proteins within the endolysosomal pathway. Although implicated in both Parkinson’s and Alzheimer’s disease, our understanding of retromer function in the
Externí odkaz:
https://doaj.org/article/fd37c61344b94ec8a6a73a0cbd9977c7
Autor:
Oguz Kanca, Jonathan Zirin, Jorge Garcia-Marques, Shannon Marie Knight, Donghui Yang-Zhou, Gabriel Amador, Hyunglok Chung, Zhongyuan Zuo, Liwen Ma, Yuchun He, Wen-Wen Lin, Ying Fang, Ming Ge, Shinya Yamamoto, Karen L Schulze, Yanhui Hu, Allan C Spradling, Stephanie E Mohr, Norbert Perrimon, Hugo J Bellen
Publikováno v:
eLife, Vol 8 (2019)
We previously reported a CRISPR-mediated knock-in strategy into introns of Drosophila genes, generating an attP-FRT-SA-T2A-GAL4-polyA-3XP3-EGFP-FRT-attP transgenic library for multiple uses (Lee et al., 2018a). The method relied on double stranded DN
Externí odkaz:
https://doaj.org/article/fbf9b18e540242aa9bc3f668e020beb1
Autor:
Berrak Ugur, Huan Bao, Michal Stawarski, Lita R. Duraine, Zhongyuan Zuo, Yong Qi Lin, G. Gregory Neely, Gregory T. Macleod, Edwin R. Chapman, Hugo J. Bellen
Publikováno v:
Cell Reports, Vol 21, Iss 13, Pp 3794-3806 (2017)
Neurotransmission is a tightly regulated Ca2+-dependent process. Upon Ca2+ influx, Synaptotagmin1 (Syt1) promotes fusion of synaptic vesicles (SVs) with the plasma membrane. This requires regulation at multiple levels, but the role of metabolites in
Externí odkaz:
https://doaj.org/article/b24801dd51874639a39d00f98dc8ed88
Autor:
Shamsideen A. Ojelade, Tom V. Lee, Nikolaos Giagtzoglou, Lei Yu, Berrak Ugur, Yarong Li, Lita Duraine, Zhongyuan Zuo, Vlad Petyuk, Philip L. De Jager, David A. Bennett, Benjamin R. Arenkiel, Hugo J. Bellen, Joshua M. Shulman
Publikováno v:
Cell Reports, Vol 28, Iss 7, Pp 1799-1813.e5 (2019)
Summary: The Alzheimer’s disease (AD) susceptibility gene, CD2-associated protein (CD2AP), encodes an actin binding adaptor protein, but its function in the nervous system is largely unknown. Loss of the Drosophila ortholog cindr enhances neurotoxi
Externí odkaz:
https://doaj.org/article/ca55d4ee84b248f18fcf1e5379f25cc3