Intracellular Iron Deficiency and Abnormal Metabolism, Not Ferroptosis, Contributes to Homocysteine-Induced Vascular Endothelial Cell Death

Autor: Wenting Shi, Jing Zhang, Wairong Zhao, Meiyan Yue, Jie Ma, Silu Zeng, Jingyi Tang, Yu Wang, Zhongyan Zhou

Publikováno v: Biomedicines, Vol 12, Iss 10, p 2301 (2024)

Background/Objectives: Homocysteine (Hcy) and iron are factors co-related with the progression of cardiovascular diseases. The vascular endothelium is an important barrier for physiological homeostasis, and its impairment initiates cardiovascular inj

Externí odkaz: https://doaj.org/article/961adf6e0dc8450f9af3bbc95bff9b54

Luteolin Prevents Cardiac Dysfunction and Improves the Chemotherapeutic Efficacy of Doxorubicin in Breast Cancer

Autor: Youyang Shi, Feifei Li, Man Shen, Chenpin Sun, Wei Hao, Chunyu Wu, Ying Xie, Shuai Zhang, Hongzhi Gao, Jianfeng Yang, Zhongyan Zhou, Dongwen Gao, Yuenong Qin, Xianghui Han, Sheng Liu

Publikováno v: Frontiers in Cardiovascular Medicine, Vol 8 (2021)

Background: Doxorubicin (Dox) is one of the most effective chemotherapy agents used in the treatment of solid tumors and hematological malignancies. However, it causes dose-related cardiotoxicity that may lead to heart failure in patients. Luteolin (

Externí odkaz: https://doaj.org/article/8737b41ba0904b3695f895d1aa405b76

Luteolin Prevents Cardiac Dysfunction and Improves the Chemotherapeutic Efficacy of Doxorubicin in Breast Cancer

Autor: Wei Hao, Dongwen Gao, Yuenong Qin, Hongzhi Gao, Ying Xie, Xianghui Han, Youyang Shi, Feifei Li, Shuai Zhang, Jianfeng Yang, Chenpin Sun, Chunyu Wu, Man Shen, Zhongyan Zhou, Sheng Liu

Publikováno v: Frontiers in Cardiovascular Medicine, Vol 8 (2021)
Frontiers in Cardiovascular Medicine

Background: Doxorubicin (Dox) is one of the most effective chemotherapy agents used in the treatment of solid tumors and hematological malignancies. However, it causes dose-related cardiotoxicity that may lead to heart failure in patients. Luteolin (

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::075a68e2599d9cad5e8f3c6774d2f8e0

Identification of necroptosis-related genes in Parkinson's disease by integrated bioinformatics analysis and experimental validation.

Autor: Lei C; Department of Tuina, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China., Zhongyan Z; Cardiovascular Research Laboratory, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China., Wenting S; Cardiovascular Research Laboratory, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China., Jing Z; Cardiovascular Research Laboratory, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China., Liyun Q; Department of Neurology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China., Hongyi H; Cardiovascular Research Laboratory, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China., Juntao Y; Department of Tuina, Yueyang Hospital of Integrated Traditional Chinese Medicine and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China., Qing Y; Department of Neurology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.

Publikováno v: Frontiers in neuroscience [Front Neurosci] 2023 May 22; Vol. 17, pp. 1097293. Date of Electronic Publication: 2023 May 22 (Print Publication: 2023).