Adenovirus type 5-expressing Gn induces better protective immunity than Gc against SFTSV infection in mice

Autor: Hua Qian, Li Tian, Wenkai Liu, Lele Liu, Menghua Li, Zhongxin Zhao, Xiaoying Lei, Wenwen Zheng, Zhongpeng Zhao, Xuexing Zheng

Publikováno v: npj Vaccines, Vol 9, Iss 1, Pp 1-13 (2024)

Abstract Severe fever with thrombocytopenia syndrome (SFTS) is caused by the SFTS virus (SFTSV) with high morbidity and mortality. The major immunodominant region of SFTSV surface glycoprotein (G) remains unclear. In this study, we constructed adenov

Externí odkaz: https://doaj.org/article/17e4ebbb724c4fc98c977d79f01fba25

Correction: Qualitative assessment of optimizing the well spacings based on the economic analysis

Autor: Wenjie Sun, Weizun Zhang, Zhongxin Zhao, Yonghui Huang, Yaqian Ren, Lu Ren, Yican Yan, Shuqin Ji, Shejiao Wang, Yanlong Kong

Publikováno v: Geothermal Energy, Vol 12, Iss 1, Pp 1-1 (2024)

Externí odkaz: https://doaj.org/article/cc85ade81fff4a778d776ea37d07ecb2

Geological characteristics and exploration practice of deep carbonate buried hills in Nanpu Sag, Bohai Bay Basin

Autor: Xiaoli YANG, Zhengjun WANG, Wenzhong GAO, Zhongxin ZHAO, Qian MA, Qi WANG, Hongchen ZHANG

Publikováno v: Shiyou shiyan dizhi, Vol 44, Iss 3, Pp 425-432 (2022)

The deep carbonate buried hills are widely distributed in the Nanpu Sag of Bohai Bay Basin. They have experienced multiple stages of tectonic movement and show a tectonic pattern of alternating sub-sags and uplifts. Exploration discoveries have been

Externí odkaz: https://doaj.org/article/c69e571bdc8e44b28c539b9d007f96e0

A 36-week multicenter, randomized, double-blind, placebo-controlled, parallel-group, phase 3 clinical trial of sodium oligomannate for mild-to-moderate Alzheimer’s dementia

Autor: Shifu Xiao, Piu Chan, Tao Wang, Zhen Hong, Shuzhen Wang, Weihong Kuang, Jincai He, Xiaoping Pan, Yuying Zhou, Yong Ji, Luning Wang, Yan Cheng, Ying Peng, Qinyong Ye, Xiaoping Wang, Yuncheng Wu, Qiumin Qu, Shengdi Chen, Shuhua Li, Wei Chen, Jun Xu, Dantao Peng, Zhongxin Zhao, Yansheng Li, Junjian Zhang, Yifeng Du, Weixian Chen, Dongsheng Fan, Yong Yan, Xiaowei Liu, Wei Zhang, Benyan Luo, Wenyuan Wu, Lu Shen, Chunfeng Liu, Peixian Mao, Qiumei Wang, Qianhua Zhao, Qihao Guo, Yongtao Zhou, Yi Li, Lijun Jiang, Wenwei Ren, Yingjun Ouyang, Yan Wang, Shuai Liu, Jianjun Jia, Nan Zhang, Zhonglin Liu, Raoli He, Tingyi Feng, Wenhui Lu, Huidong Tang, Ping Gao, Yingchun Zhang, Lanlan Chen, Lei Wang, You Yin, Qun Xu, Jinsong Xiao, Lin Cong, Xi Cheng, Hui Zhang, Dan Gao, Minghua Xia, Tenghong Lian, Guoping Peng, Xu Zhang, Bin Jiao, Hua Hu, Xueyan Chen, Yihui Guan, Ruixue Cui, Qiu Huang, Xianliang Xin, Hongjian Chen, Yu Ding, Jing Zhang, Teng Feng, Marc Cantillon, Kewei Chen, Jeffrey L. Cummings, Jian Ding, Meiyu Geng, Zhenxin Zhang

Publikováno v: Alzheimer’s Research & Therapy, Vol 13, Iss 1, Pp 1-11 (2021)

Abstract Background New therapies are urgently needed for Alzheimer’s disease (AD). Sodium oligomannate (GV-971) is a marine-derived oligosaccharide with a novel proposed mechanism of action. The first phase 3 clinical trial of GV-971 has been comp

Externí odkaz: https://doaj.org/article/be6ea2cb11804b00bae73772fe2c6adc

A Bivalent Human Adenovirus Type 5 Vaccine Expressing the Rabies Virus Glycoprotein and Canine Distemper Virus Hemagglutinin Protein Confers Protective Immunity in Mice and Foxes

Autor: Lina Yan, Zhongxin Zhao, Xianghong Xue, Wenwen Zheng, Tong Xu, Lele Liu, Li Tian, Xianwei Wang, Hongbin He, Xuexing Zheng

Publikováno v: Frontiers in Microbiology, Vol 11 (2020)

The development of a safe and efficient multivalent vaccine has great prospects for application. Both rabies virus (RABV) and canine distemper virus (CDV) are highly infectious antigens, causing lethal diseases in domestic dogs and other carnivores w

Externí odkaz: https://doaj.org/article/e7419d0787fe4ddf9696de922a2ba183