Výsledky vyhledávání - "Zhongxi (Zack) Zhao"

Study of degradation mechanisms of cyclobenzaprine by LC-MS/MS

Autor: Dantong Zhao, Yan Liu, Zhongxi (Zack) Zhao

Publikováno v: Anal. Methods. 6:2320-2330

A systematic forced degradation study of cyclobenzaprine (CBA) for the elucidation of the degradation mechanism was carried out in this work to support the new formulation development. Various forced degradation conditions such as acid and base hydro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::40902b20b703e961f58be030a539aedd
https://doi.org/10.1039/c3ay41409d

Zobrazit plný text záznamu

Identification by LC/MSn of degradates of a novel carbapenem antibiotic in an aqueous matrix

Autor: Zhongxi Zack Zhao, Xue Zhi Qin, Robert A. Reed

Publikováno v: Journal of Pharmaceutical and Biomedical Analysis. 29:173-181

Increased drug resistance in Staphylcocci and Enterococci to currently available antibiotics has significantly limited therapeutic options. Recently, a novel carbapenem antibiotic (Compound A) with a releasable side chain adjacent to the carbapenem w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9cc7e0887c19cfec5f0268112face4ed
https://doi.org/10.1016/s0731-7085(02)00008-0

Zobrazit plný text záznamu

Novel rearrangements of an N-oxide degradate formed from oxidation of a morpholine acetal substance P antagonist

Autor: Allen Wu, Zhongxi Zack Zhao, Xue-Zhi Qin, Yang Yuan

Publikováno v: Journal of pharmaceutical sciences. 93(8)

Compound 1 {5-[2(R)-[1(R)-(3,5-bistrifluoromethylphenyl) ethoxy]-3(s)-(4-fluorophenyl)morpholin-4-ylmethyl]-3h-[1,2,3] triazol-4-ylmethyl}dimethylamine represents a new class of potent, orally active substance P antagonists, which possess a character

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49a0663227cbbf80cd3aff1d94bd3899
https://pubmed.ncbi.nlm.nih.gov/15236446

Zobrazit plný text záznamu

Identification and quantitation of extractables from cellulose acetate butyrate (CAB) and estimation of their in vivo exposure levels

Autor: Steven M. Pitzenberger, Paul A. Harmon, Christopher A Beasley, Decheng Ma, John M. Ballard, Walter R Wasylaschuk, Robert A. Reed, Zhongxi Zack Zhao, Sandor L. Varga

Publikováno v: Journal of pharmaceutical and biomedical analysis. 35(4)

The purpose of this study was to qualitatively and quantitatively determine potential cellulose acetate butyrate (CAB) extractables in a way to meaningfully predict the in vivo exposure resulting from clinical administration. Extractions of CAB-381-2

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d70066d59a16eb9ab0e4affb0b89d005
https://pubmed.ncbi.nlm.nih.gov/15193722

Zobrazit plný text záznamu

Identification of losartan degradates in stressed tablets by LC-MS and LC-MS/MS

Autor: Qingxi Wang, Eric W. Tsai, Zhongxi (Zack) Zhao, Xue-Zhi Qin, Dominic P. Ip

Publikováno v: Journal of pharmaceutical and biomedical analysis. 20(1-2)

Three unknown peaks were observed in the severely stressed losartan tablets (at 40 degrees C and 75% relative humidity for 3 years) analyzed by a stability indicating HPLC method. The sample solutions were subjected to liquid chromatography-tandem ma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c52497c3165cadebea7bcc0031277b4e
https://pubmed.ncbi.nlm.nih.gov/10704016

Zobrazit plný text záznamu