Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Zhongwang Yu"'
Autor:
Zhongwang Yu, Xue Fang, Weili Liu, Rui Sun, Jintao Zhou, Yingyan Pu, Ming Zhao, Dingya Sun, Zhenghua Xiang, Peng Liu, Yuqiang Ding, Li Cao, Cheng He
Publikováno v:
Advanced Science, Vol 9, Iss 24, Pp n/a-n/a (2022)
Abstract Blood–brain barrier (BBB) impairment is an early prevalent feature of multiple sclerosis (MS), and remains vital for MS progression. Microglial activation precedes BBB disruption and cellular infiltrates in the brain of MS patients. Howeve
Externí odkaz:
https://doaj.org/article/e3307dda0fc64b669651d6d415a2d7a6
Publikováno v:
BMC Bioinformatics, Vol 20, Iss 1, Pp 1-11 (2019)
Abstract Background The knowledge-based statistical potential has been widely used in protein structure modeling and model quality assessment. They are commonly evaluated based on their abilities of native recognition as well as decoy discrimination.
Externí odkaz:
https://doaj.org/article/c0abc7c53c9a49beb0554190d772c58f
Publikováno v:
PLoS ONE, Vol 5, Iss 4, p e9956 (2010)
BACKGROUND: The pathology of Parkinson's disease (PD) is characterized by the degeneration of the nigrostriatal dopaminergic pathway, as well as the formation of intraneuronal inclusions known as Lewy bodies and Lewy neurites in the substantia nigra.
Externí odkaz:
https://doaj.org/article/b80a0240383b4951af028eee0be1f77d
Autor:
Hong Liu, Zhongwang Yu, Cao Li, Benqiang Deng, Pu Yingyan, Weili Liu, Wenwen Pei, Ming Zhao, Kefu Chen, Mingdong Liu, Qi Shao
Publikováno v:
Neurosci Bull
The exacerbation of progressive multiple sclerosis (MS) is closely associated with obstruction of the differentiation of oligodendrocyte progenitor cells (OPCs). To discover novel therapeutic compounds for enhancing remyelination by endogenous OPCs,
Autor:
Chao Zhao, Zhongwang Yu, Dou Yin, Li Cao, Weili Liu, Fengfeng Lu, Mei Zhu, Yingyan Pu, Cheng He
Publikováno v:
Journal of Neuroimmunology. 313:152-160
Multiple sclerosis (MS) is a chronic autoimmune demyelinating disease of the central nervous system. Currently, there is no drug available to cure this kind of disease. Diosgenin is a plant-derived steroid saponin. A previous study in our lab reveale
Autor:
Dingya Sun, Aijun Huang, Dan Wang, Cheng He, Zhongwang Yu, Li Cao, Zhenghua Xiang, Xue Fang, Yingyan Pu, Zhihong Wang, Mingdong Liu, Weili Liu
Publikováno v:
Neuroscience Bulletin. 33:603-615
Multiple sclerosis (MS) is a classical inflammatory demyelinating disease of the central nervous system (CNS). Microglia are the main resident immune cells in the CNS and are closely associated with the pathogenesis of MS. In the present study, we fo
Figure S1. Effects of distance cutoff on ANDISâ s performance for different decoy sets. Figure S2. Effects of protein dataset on ANDISâ s performance for different decoy sets. (DOCX 222 kb)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39e64e712083040ddb3ad33e47844831
Autor:
Aijun Huang, Zhongwang Yu, Li Cao, Yingyan Pu, Jifeng Feng, Dou Yin, Yimin Yuan, Cheng He, Dunxin Han, Weili Liu
Publikováno v:
Cell Death & Disease
Cell Death and Disease, Vol 9, Iss 2, Pp 1-16 (2018)
Cell Death and Disease, Vol 9, Iss 2, Pp 1-16 (2018)
Spinal cord injury (SCI) is a devastating type of central nervous system (CNS) trauma with limited therapeutic treatments. The polarization of microglia into the M1 or M2 state has been documented to play important roles in the pathogenesis of SCI, a
Publikováno v:
Journal of Biological Chemistry. 288:12152-12160
LINGO-1 is a functional component of the Nogo receptor 1 · p75(NTR) · LINGO-1 and Nogo receptor 1 · TAJ (TNFRSF19/TROY)·LINGO-1 signaling complexes. It has recently been shown that LINGO-1 antagonists significantly improve neuronal survival after
Autor:
Xiao-Hui Xu, Ting-Zhao Li, Wei-Dong Zhang, Cheng He, Zhongwang Yu, Zhenghua Xiang, Lei Shan, Zhaohuan Zhang, Jianfeng Zhou
Publikováno v:
Neuroscience Letters. 460:41-46
Myelin contains many axonal outgrowth inhibitory components which contribute to regeneration failure after neuronal injury in the mammalian central nervous system (CNS). In an attempt to develop small molecular agents to promote axonal outgrowth, we