Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Zhongshu, Song"'
Autor:
Trong-Tuan Dao, Katherine Williams, Kate M. J. de Mattos-Shipley, Zhongshu Song, Yuiko Takebayashi, Thomas J. Simpson, James Spencer, Andrew M. Bailey, Christine L. Willis
Publikováno v:
Dao, T T, Williams, K, de Mattos-Shipley, K M J, Song, Z, Takebayashi, Y, Simpson, T J, Spencer, J, Bailey, A M & Willis, C L 2022, ' Cladobotric acids: Metabolites from cultures of Cladobotryum sp., semi-synthetic analogues and antibacterial activity ', Journal of Natural Products, vol. 85, no. 3, pp. 572-580 . https://doi.org/10.1021/acs.jnatprod.1c01063
Three new polyketide-derived natural products, cladobotric acids G–I (1–3), and six known metabolites (4, 5, 8–11) were isolated from fermentation of the fungus Cladobotryum sp. grown on rice. Their structures were elucidated by extensive spect
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a7e5b2521ebfde65846ed25cb388880
https://doi.org/10.1021/acs.jnatprod.1c01063
https://doi.org/10.1021/acs.jnatprod.1c01063
Autor:
Ashley J. Winter, Matthew T. Rowe, Angus N. M. Weir, Nahida Akter, Sbusisiwe Z. Mbatha, Paul D. Walker, Christopher Williams, Zhongshu Song, Paul R. Race, Christine L. Willis, Matthew P. Crump
Publikováno v:
Winter, A J, Rowe, M T, Weir, A N M, Akter, N, Mbatha, S Z, Walker, P D, Williams, C, Song, Z, Race, P R, Willis, C L & Crump, M P 2022, ' Programmed Iteration Controls the Assembly of the Nonanoic Acid Side Chain of the Antibiotic Mupirocin ', Angewandte Chemie-International Edition, vol. 61, no. 50, e202212393 . https://doi.org/10.1002/anie.202212393
Mupirocin is a clinically important antibiotic produced by Pseudomonas fluorescens NCIMB 10586 that is assembled by a complex trans-AT polyketide synthase. The polyketide fragment, monic acid, is esterified by a 9-hydroxynonanoic acid (9HN) side chai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8f3287f7bbdf8f76bb39e10e426174f
https://pubmed.ncbi.nlm.nih.gov/36227272
https://pubmed.ncbi.nlm.nih.gov/36227272
Autor:
Zhongshu Song, Paul R. Race, Thomas J. Simpson, Christine L. Willis, Luoyi Wang, Matthew P. Crump, James Spencer
Publikováno v:
Chemical Science
Wang, L, Song, Z, Race, P R, Spencer, J, Simpson, T J, Crump, M P & Willis, C L 2020, ' Mixing and Matching Genes of Marine and Terrestrial Origin in the Biosynthesis of the Mupirocin Antibiotics ', Chemical Science, vol. 11, pp. 5221-5226 . https://doi.org/10.1039/C9SC06192D
Wang, L, Song, Z, Race, P R, Spencer, J, Simpson, T J, Crump, M P & Willis, C L 2020, ' Mixing and Matching Genes of Marine and Terrestrial Origin in the Biosynthesis of the Mupirocin Antibiotics ', Chemical Science, vol. 11, pp. 5221-5226 . https://doi.org/10.1039/C9SC06192D
With growing understanding of the underlying pathways of polyketide biosynthesis, along with the continual expansion of the synthetic biology toolkit, it is becoming possible to rationally engineer and fine-tune the polyketide biosynthetic machinery
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4507f2147d0cfad2182b049321a14299
http://europepmc.org/articles/PMC8159325
http://europepmc.org/articles/PMC8159325
Autor:
Nahida Akter, Matthew T. Rowe, Ashley J. Winter, Christine L. Willis, Christopher Williams, Matthew P. Crump, Thomas J. Simpson, Paul R. Race, Zhongshu Song, Angus N M Weir, Luoyi Wang, Paul D. Walker
Publikováno v:
Walker, P D, Rowe, M T, Winter, A J, Weir, A N M, Akter, N, Wang, L, Race, P R, Williams, C, Song, Z, Simpson, T J, Willis, C L & Crump, M P 2020, ' A Priming Cassette Generates Hydroxylated Acyl Starter Units in Mupirocin and Thiomarinol Biosynthesis ', ACS Chemical Biology, vol. 2020 . https://doi.org/10.1021/acschembio.9b00969
Mupirocin, a commercially available antibiotic produced by Pseudomonas fluorescens NCIMB 10586, and thiomarinol, isolated from the marine bacterium Pseudoalteromonas sp. SANK 73390, both consist of a polyketide-derived monic acid homologue esterified
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea14d9c93247b430f0a870296365c246
https://doi.org/10.1021/acschembio.9b00969
https://doi.org/10.1021/acschembio.9b00969
Autor:
Zhongshu Song, Agniezka J. Szwalbe, Andy M. Bailey, Thomas J. Simpson, Jason Leigh Vincent, Kate M. J. de Mattos-Shipley, Russell J. Cox, Katherine Williams, Christine L. Willis
Publikováno v:
Szwalbe, A J, Williams, K, Song, Z, De Mattos-Shipley, K, Vincent, J L, Bailey, A M, Willis, C L, Cox, R J & Simpson, T J 2019, ' Characterisation of the biosynthetic pathway to agnestins A and B reveals the reductive route to chrysophanol in fungi ', Chemical Science, vol. 10, no. 1, pp. 233-238 . https://doi.org/10.1039/C8SC03778G
Chemical Science
Chemical Science 10 (2019), Nr. 1
Chemical Science
Chemical Science 10 (2019), Nr. 1
Identification of a reductase (AgnL4) confirms that in vivo anthraquinone to anthrol conversion is an essential first step in aromatic deoxygenation of anthraquinones catalysed by AgnL6 (reductase) and AgnL8 (dehydratase).
Two new dihydroxy-xant
Two new dihydroxy-xant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c627954ae8b7e446a301babd5e5d8309
https://doi.org/10.1039/c8sc03778g
https://doi.org/10.1039/c8sc03778g
Autor:
Kate M. J. de Mattos-Shipley, Christine L. Willis, Andy M. Bailey, Trong Tuan Dao, Zhongshu Song, David M. Heard, Nicholas Phillip Mulholland, Daniel E. O’Flynn, Claudio Greco, Thomas J. Simpson, Catherine E Spencer, Russell J. Cox, Jason Leigh Vincent
Publikováno v:
De Mattos-Shipley, K M J, Spencer, C E, Greco, C, Heard, D M, O'Flynn, D E, Dao, T T, Song, Z, Mullholland, N P, Vincent, J L, Simpson, T J, Cox, R J, Bailey, A M & Willis, C L 2020, ' Uncovering Biosynthetic Relationships Between Antifungal Nonadrides and Octadrides ', Chemical Science, vol. 11, pp. 11570-11578 . https://doi.org/10.1039/D0SC04309E
Chemical Science 11 (2020), Nr. 42
Chemical Science
Chemical Science 11 (2020), Nr. 42
Chemical Science
Maleidrides are a class of bioactive secondary metabolites unique to filamentous fungi, which contain one or more maleic anhydrides fused to a 7-, 8- or 9- membered carbocycle (named heptadrides, octadrides and nonadrides respectively). Herein struct
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3445f4bc2a57393a14f8131fb4a86a04
https://research-information.bris.ac.uk/ws/files/254590048/d0sc04309e.pdf
https://research-information.bris.ac.uk/ws/files/254590048/d0sc04309e.pdf
A natural plasmid uniquely encodes two biosynthetic pathways creating a potent anti-MRSA antibiotic.
Autor:
Daisuke Fukuda, Anthony S Haines, Zhongshu Song, Annabel C Murphy, Joanne Hothersall, Elton R Stephens, Rachel Gurney, Russell J Cox, John Crosby, Christine L Willis, Thomas J Simpson, Christopher M Thomas
Publikováno v:
PLoS ONE, Vol 6, Iss 3, p e18031 (2011)
Understanding how complex antibiotics are synthesised by their producer bacteria is essential for creation of new families of bioactive compounds. Thiomarinols, produced by marine bacteria belonging to the genus Pseudoalteromonas, are hybrids of two
Externí odkaz:
https://doaj.org/article/f65d8ef4119a44789cb398feeee148db
Autor:
Trong-Tuan Dao, Williams, Katherine, de Mattos-Shipley, Kate M. J., Zhongshu Song, Yuiko Takebayashi, Simpson, Thomas J., Spencer, James, Bailey, Andrew M., Willis, Christine L., Dao, Trong-Tuan, Song, Zhongshu, Takebayashi, Yuiko
Publikováno v:
Journal of Natural Products; 3/25/2022, Vol. 85 Issue 3, p572-580, 9p
Autor:
Shu-Shan Gao, Luoyi Wang, Zhongshu Song, Joanne Hothersall, Elton R. Stevens, Jack Connolly, Peter J. Winn, Russell J. Cox, Matthew P. Crump, Paul R. Race, Christopher M. Thomas, Thomas J. Simpson, Christine L. Willis
Publikováno v:
Angewandte Chemie. 129:3988-3992
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::27b63e99e595f28a702cd79dda8067e7
https://doi.org/10.1002/ange.201611590
https://doi.org/10.1002/ange.201611590
Autor:
Matthew P. Crump, Zhongshu Song, Paul R. Race, Freya M. Bull, Joleen Masschelein, Luoyi Wang, Chengsen Cui, Thomas J. Simpson, Rob Lavigne, Shu-Shan Gao, Iain R. G. Thistlethwaite, Paul D. Walker, Christine L. Willis
Publikováno v:
Thistlethwaite, I, Bull, F, Cui, C, Walker, P, Gao, S-S, Wang, L, Song, Z, Masschelein, J, Lavigne, R, Crump, M, Race, P, Simpson, T & Willis, C 2017, ' Elucidation of the relative and absolute stereochemistry of the kalimantacin/batumin antibiotics ', Chemical Science, vol. 8, no. 9, pp. 6196-6201 . https://doi.org/10.1039/c7sc01670k
Kalimantacin A and batumin exhibit potent and selective antibiotic activity against Staphylococcus species including MRSA. Both compounds are formed via a hybrid polyketide synthase/non-ribosomal peptide synthetase (PKS-NRPS) biosynthetic pathway and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3662ddf69f7462797894d3303bda55ef
https://doi.org/10.1039/c7sc01670k
https://doi.org/10.1039/c7sc01670k