Cosmic kidney disease: an integrated pan-omic, physiological and morphological study into spaceflight-induced renal dysfunction

Autor: Keith Siew, Kevin A. Nestler, Charlotte Nelson, Viola D’Ambrosio, Chutong Zhong, Zhongwang Li, Alessandra Grillo, Elizabeth R. Wan, Vaksha Patel, Eliah Overbey, JangKeun Kim, Sanghee Yun, Michael B. Vaughan, Chris Cheshire, Laura Cubitt, Jessica Broni-Tabi, Maneera Yousef Al-Jaber, Valery Boyko, Cem Meydan, Peter Barker, Shehbeel Arif, Fatemeh Afsari, Noah Allen, Mohammed Al-Maadheed, Selin Altinok, Nourdine Bah, Samuel Border, Amanda L. Brown, Keith Burling, Margareth Cheng-Campbell, Lorianna M. Colón, Lovorka Degoricija, Nichola Figg, Rebecca Finch, Jonathan Foox, Pouya Faridi, Alison French, Samrawit Gebre, Peter Gordon, Nadia Houerbi, Hossein Valipour Kahrood, Frederico C. Kiffer, Aleksandra S. Klosinska, Angela Kubik, Han-Chung Lee, Yinghui Li, Nicholas Lucarelli, Anthony L. Marullo, Irina Matei, Colleen M. McCann, Sayat Mimar, Ahmed Naglah, Jérôme Nicod, Kevin M. O’Shaughnessy, Lorraine Christine De Oliveira, Leah Oswalt, Laura Ioana Patras, San-huei Lai Polo, María Rodríguez-Lopez, Candice Roufosse, Omid Sadeghi-Alavijeh, Rebekah Sanchez-Hodge, Anindya S. Paul, Ralf Bernd Schittenhelm, Annalise Schweickart, Ryan T. Scott, Terry Chin Choy Lim Kam Sian, Willian A. da Silveira, Hubert Slawinski, Daniel Snell, Julio Sosa, Amanda M. Saravia-Butler, Marshall Tabetah, Erwin Tanuwidjaya, Simon Walker-Samuel, Xiaoping Yang, Yasmin, Haijian Zhang, Jasminka Godovac-Zimmermann, Pinaki Sarder, Lauren M. Sanders, Sylvain V. Costes, Robert A. A. Campbell, Fathi Karouia, Vidya Mohamed-Alis, Samuel Rodriques, Steven Lynham, Joel Ricky Steele, Sergio Baranzini, Hossein Fazelinia, Zhongquan Dai, Akira Uruno, Dai Shiba, Masayuki Yamamoto, Eduardo A.C.Almeida, Elizabeth Blaber, Jonathan C. Schisler, Amelia J. Eisch, Masafumi Muratani, Sara R. Zwart, Scott M. Smith, Jonathan M. Galazka, Christopher E. Mason, Afshin Beheshti, Stephen B. Walsh

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-20 (2024)

Abstract Missions into Deep Space are planned this decade. Yet the health consequences of exposure to microgravity and galactic cosmic radiation (GCR) over years-long missions on indispensable visceral organs such as the kidney are largely unexplored

Externí odkaz: https://doaj.org/article/314b862fbe6c4c54a23cb008317e48c9

Triple-gene deletion for osteocalcin significantly impairs the alignment of hydroxyapatite crystals and collagen in mice

Autor: Zihan Xu, Chao Yang, Feng Wu, Xiaowen Tan, Yaxiu Guo, Hongyu Zhang, Hailong Wang, Xiukun Sui, Zi Xu, Minbo Zhao, Siyu Jiang, Zhongquan Dai, Yinghui Li

Publikováno v: Frontiers in Physiology, Vol 14 (2023)

Osteocalcin (Ocn), also known as bone Gla protein, is synthesized by osteoblasts and thought to regulate energy metabolism, testosterone synthesis and brain development. However, its function in bone is not fully understood. Mice have three Ocn genes

Externí odkaz: https://doaj.org/article/887cc6fd1c4e4789894ddb67e7f60b67

Hepatic metabolite responses to 4-day complete fasting and subsequent refeeding in rats

Autor: Xiukun Sui, Hailong Wang, Feng Wu, Chao Yang, Hongyu Zhang, Zihan Xu, Yaxiu Guo, ZhiFeng Guo, Bingmu Xin, Ting Ma, Yinghui Li, Zhongquan Dai

Publikováno v: PeerJ, Vol 10, p e14009 (2022)

Background Fasting has been widely used to improve various metabolic diseases in humans. Adaptive fasting is necessary for metabolic adaptation during prolonged fasting, which could overcome the great advantages of short-term fasting. The liver is th

Externí odkaz: https://doaj.org/article/d31f6daac3894fcaabfaaad1ac38d5cd

How Experiences Affect Psychological Responses During Supervised Fasting: A Preliminary Study

Autor: Qianying Ma, Chao Yang, Ruilin Wu, Manrui Wu, Wenjun Liu, Zhongquan Dai, Yinghui Li

Publikováno v: Frontiers in Psychology, Vol 12 (2021)

As an unusual event, fasting can induce strong physiological and psychological reactions, but there is still no clear understanding of how previous fasting experiences affect people’s responses to current fasting. This study aimed to investigate th

Externí odkaz: https://doaj.org/article/d5b8ad0463234ef0973e50b677bd7c53

Serum Metabolomics Associating With Circulating MicroRNA Profiles Reveal the Role of miR-383-5p in Rat Hippocampus Under Simulated Microgravity

Autor: Hongyu Zhang, Jian Chen, Hailong Wang, Xin Lu, Kai Li, Chao Yang, Feng Wu, Zihan Xu, Huan Nie, Bai Ding, Zhifeng Guo, Yu Li, Jinfu Wang, Yinghui Li, Zhongquan Dai

Publikováno v: Frontiers in Physiology, Vol 11 (2020)

Microgravity impacts various aspects of human health. Yet the mechanisms of spaceflight-induced health problems are not elucidated. Here, we mapped the fusion systemic analysis of the serum metabolome and the circulating microRNAome in a hindlimb unl

Externí odkaz: https://doaj.org/article/b62a0439e38941dbbcad90c6d1f87c47