Metabolomics- and systems toxicology-based hepatotoxicity mechanism of Sophorae Tonkinensis Radix et Rhizoma in rats

Autor: Dengxiang Yu, Zhen Shao, Yuemeng Fu, Xiaohang Tang, Qilong Chen, Zhongping Deng

Publikováno v: Frontiers in Pharmacology, Vol 13 (2022)

Drug-induced liver injury (DILI) is a major challenge to the development and clinical application of drugs, especially limits the global application of Chinese herbal medicines, because the material basis and mechanisms of some Chinese herbal medicin

Externí odkaz: https://doaj.org/article/c67d0ad1c3f1440b98a86920fabd7848

Aristolochic acid I promoted clonal expansion but did not induce hepatocellular carcinoma in adult rats

Autor: Xiao-lan Ding, Fangfang Yang, Yong-zhen Liu, Likun Gong, Ze-an Zhang, Zhongping Deng, Xinming Qi, Jin Ren, Pan Yu, Lu Liu, Xin Wang, Henglei Lu, Guozhen Xing

Publikováno v: Acta Pharmacol Sin

Aristolochic acid I (AAI) is a well-known nephrotoxic carcinogen, which is currently reported to be also associated with hepatocellular carcinoma (HCC). Whether AAI is a direct hepatocarcinogen remains controversial. In this study we investigated the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c37b3d5118e00f484ab2d57d350b1b9b
https://doi.org/10.1038/s41401-021-00622-7

Aristolochic acid I induces impairment in spermatogonial stem cell in rodents

Autor: Likun Gong, Xiang He, Yuan Zhang, Fangfang Yang, Xinming Qi, Zhaochu Wang, Yuli Wang, Henglei Lu, Jianyun Ma, Yifu Yang, Jin Ren, Houzu Zhou, Zhongping Deng, Yongzhen Liu

Publikováno v: Toxicol Res (Camb)

Aristolochic acid I (AAI) is a natural bioactive substance found in plants from the Aristolochiaceae family and impairs spermatogenesis. However, whether AAI-induced spermatogenesis impairment starts at the early stages of spermatogenesis has not yet

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40322142ac703b1759bba22ea13d058a
https://europepmc.org/articles/PMC8201548/

Oxidative stress and antioxidant defense in detoxification systems of snake venom-induced toxicity

Autor: Chen Qi, Wenli Mao, Qiang Li, Wang Wanchun, Yi Jun, Zhangren Yan, Degang Dong, Liang Liu, Zhongping Deng, Mei Song, Jun Chen, Xiuqin Huang, Xi Wang

Publikováno v: Journal of Venomous Animals and Toxins including Tropical Diseases, Volume: 26, Article number: e20200053, Published: 19 OCT 2020
Journal of Venomous Animals and Toxins including Tropical Diseases v.26 2020
The Journal of venomous animals and toxins including tropical diseases
Universidade Estadual Paulista (UNESP)
instacron:UNESP
The Journal of Venomous Animals and Toxins Including Tropical Diseases
Journal of Venomous Animals and Toxins including Tropical Diseases, Vol 26 (2020)

Background: Snakebites remain a major life-threatening event worldwide. It is still difficult to make a positive identification of snake species by clinicians in both Western medicine and Chinese medicine. The main reason for this is a shortage of di

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52a3df0a7b5a9096129f4b1ab08b2a38
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992020000100333&lng=en&tlng=en

Corrigendum to: Aristolochic acid I induces impairment in spermatogonial stem cell in rodents

Autor: Jin Ren, Yuan Zhang, Fangfang Yang, Xiang He, Xinming Qi, Zhaochu Wang, Yuli Wang, Jianyun Ma, Likun Gong, Yifu Yang, Houzu Zhou, Henglei Lu, Zhongping Deng, Yongzhen Liu

Publikováno v: Toxicology Research. 10:959-959

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::325f1e1efb7076f9798827c3f4252f18
https://doi.org/10.1093/toxres/tfab061