Zobrazeno 1 - 10 of 56 pro vyhledávání: '"Zhongju Lu"'
1
Akademický článek
The association of QTc prolongation with cardiovascular events in cancer patients taking tyrosine kinase inhibitors (TKIs)
Autor: Ismail Ghafary, Chang-Kyung Kim, Eric Roth, Michael Lu, Erin M. Taub, Susan Lee, Ira Cohen, Zhongju Lu
Publikováno v: Cardio-Oncology, Vol 9, Iss 1, Pp 1-11 (2023)
Abstract Objective To investigate the association between stages of QTc prolongation and the risk of cardiac events among patients on TKIs. Methods This was a retrospective cohort study performed at an academic tertiary care center of cancer patients
Externí odkaz: https://doaj.org/article/cf37407463bf4ba0bb61202449cb3345
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2
Akademický článek
The Risk of QTc Prolongation in Non-Diabetic and Diabetic Patients Taking Tyrosine Kinase Inhibitors (TKIs)- A Patient Safety Project at a Private Oncology Practice
Autor: Zhongju Lu, Ying Luu, Jack Ip, Imran Husain, Michael Lu, Chang-Kyung Kim, Peng Yang, David Chu, Richard Lin, Ira Cohen, Alan Kaell
Publikováno v: Journal of Community Hospital Internal Medicine Perspectives, Vol 11, Iss 6, Pp 799-807 (2021)
Objective: To assess the prevalence of QTc prolongation in both non-diabetic and diabetic patients on TKIs. Some TKIs have been reported to cause QTc prolongation, which is prevalent in diabetes. However, there is no Risk Evaluation and Mitigation St
Externí odkaz: https://doaj.org/article/20bfe2a793834e6c83b9085c1c5d4940
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3
Akademický článek
Regulation of HCN2 Current by PI3K/Akt Signaling
Autor: Zhongju Lu, Hong Zhan Wang, Chris R. Gordon, Lisa M. Ballou, Richard Z. Lin, Ira S. Cohen
Publikováno v: Frontiers in Physiology, Vol 11 (2020)
It has long been known that heart rate is regulated by the autonomic nervous system. Recently, we demonstrated that the pacemaker current, If, is regulated by phosphoinositide 3-kinase (PI3K) signaling independently of the autonomic nervous system. I
Externí odkaz: https://doaj.org/article/4b0af37d918243b786b650aaacfa599c
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4
Akademický článek
Prevalence of QT prolongation and associated LVEF changes in diabetic patients over a four-year retrospective time period
Autor: Zhongju Lu, Lloyd Lense, Mohit Sharma, Ankit Shah, Ying Luu, Lucien Cardinal, Joan Faro, Alan Kaell
Publikováno v: Journal of Community Hospital Internal Medicine Perspectives, Vol 7, Iss 2, Pp 87-94 (2017)
Aim: To evaluate the prevalence and longitudinal changes of prolonged QTc in DM patients admitted to our community hospital, and to determine, if any, its correlation with changes of left ventricular ejection fraction (LVEF). Methods: A retrospective
Externí odkaz: https://doaj.org/article/97e876d4c90c4d8dae479f0d06a189ba
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5
Akademický článek
Computational optogenetics: empirically-derived voltage- and light-sensitive channelrhodopsin-2 model.
Autor: John C Williams, Jianjin Xu, Zhongju Lu, Aleksandra Klimas, Xuxin Chen, Christina M Ambrosi, Ira S Cohen, Emilia Entcheva
Publikováno v: PLoS Computational Biology, Vol 9, Iss 9, p e1003220 (2013)
Channelrhodospin-2 (ChR2), a light-sensitive ion channel, and its variants have emerged as new excitatory optogenetic tools not only in neuroscience, but also in other areas, including cardiac electrophysiology. An accurate quantitative model of ChR2
Externí odkaz: https://doaj.org/article/4e29eef920094eb69f3af22a50d86070
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6
The Risk of QTc Prolongation in Non-Diabetic and Diabetic Patients Taking Tyrosine Kinase Inhibitors (TKIs)- A Patient Safety Project at a Private Oncology Practice
Autor: Ying Luu, Imran Husain, Peng Yang, David Chu, Alan Kaell, Ira L. Cohen, Zhongju Lu, Jack Ip, Michael Lu, Chang-Kyung Kim, Richard Z. Lin
Publikováno v: Journal of Community Hospital Internal Medicine Perspectives
article-version (VoR) Version of Record
Journal of Community Hospital Internal Medicine Perspectives, Vol 11, Iss 6, Pp 799-807 (2021)
Objective: To assess the prevalence of QTc prolongation in both non-diabetic and diabetic patients on TKIs. Some TKIs have been reported to cause QTc prolongation, which is prevalent in diabetes. However, there is no Risk Evaluation and Mitigation St
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58b9d8343a98267f626b89d7d958bb77
https://doi.org/10.1080/20009666.2021.1978652
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7
Modulating the voltage sensor of a cardiac potassium channel shows antiarrhythmic effects
Autor: Zhongju Lu, Junyuan Gao, Po Wei Kang, Xiaoqin Zou, Jingyi Shi, Hong Zhan Wang, Wenshan Zhao, Ira S. Cohen, Guohui Zhang, Zhiwei Ma, Kelli McFarland White, Yongfeng Liu, Yangyang Lin, Panpan Hou, Jianmin Cui, Sam Z. Grinter, Lu Zhao, Chris Clausen, Hongwu Liang, Xianjin Xu
Publikováno v: Proc Natl Acad Sci U S A
Cardiac arrhythmias are the most common cause of sudden cardiac death worldwide. Lengthening the ventricular action potential duration (APD) either congenitally or via pathologic or pharmacologic means, predisposes to a life-threatening ventricular a
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a65b60e27b475d315509356af2c2232
https://doi.org/10.1073/pnas.2024215118
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8
Prevalence of QT prolongation and associated LVEF changes in diabetic patients over a four-year retrospective time period
Autor: Mohit Sharma, Ying Luu, Ankit Shah, Alan Kaell, Lucien Cardinal, Zhongju Lu, Joan Faro, Lloyd Lense
Publikováno v: Journal of Community Hospital Internal Medicine Perspectives, Vol 7, Iss 2, Pp 87-94 (2017)
Journal of Community Hospital Internal Medicine Perspectives
Aim: To evaluate the prevalence and longitudinal changes of prolonged QTc in DM patients admitted to our community hospital, and to determine, if any, its correlation with changes of left ventricular ejection fraction (LVEF). Methods: A retrospective
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb8ab16e670815465cd250e515eb2194
https://doaj.org/article/97e876d4c90c4d8dae479f0d06a189ba
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9
Regulation of heart rate and the pacemaker current by phosphoinositide 3-kinase signaling
Autor: Evgeny P. Anyukhovsky, Richard Z. Lin, Lisa M. Ballou, Zhongju Lu, Ya-Ping Jiang, Hong Zhan Wang, Michael R. Rosen, Ira S. Cohen, Junyuan Gao
Publikováno v: The Journal of General Physiology
Heart rate in physiological conditions is set by the sinoatrial node (SN), the primary cardiac pacing tissue. Phosphoinositide 3-kinase (PI3K) signaling is a major regulatory pathway in all normal cells, and its dysregulation is prominent in diabetes
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74aa3c477da783cb71b6b82b1c949406
https://pubmed.ncbi.nlm.nih.gov/31431492
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10
Development of a Universal RNA Beacon for Exogenous Gene Detection
Autor: Zhongju Lu, Ira S. Cohen, Suzanne Scarlata, Yuanjian Guo
Publikováno v: Stem Cells Translational Medicine. 4:476-482
Stem cell therapy requires a nontoxic and high-throughput method to achieve a pure cell population to prevent teratomas that can occur if even one cell in the implant has not been transformed. A promising method to detect and separate cells expressin
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bd915657e8403add63c2cfa0c327704
https://doi.org/10.5966/sctm.2014-0166
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