The association of QTc prolongation with cardiovascular events in cancer patients taking tyrosine kinase inhibitors (TKIs)

Autor: Ismail Ghafary, Chang-Kyung Kim, Eric Roth, Michael Lu, Erin M. Taub, Susan Lee, Ira Cohen, Zhongju Lu

Publikováno v: Cardio-Oncology, Vol 9, Iss 1, Pp 1-11 (2023)

Abstract Objective To investigate the association between stages of QTc prolongation and the risk of cardiac events among patients on TKIs. Methods This was a retrospective cohort study performed at an academic tertiary care center of cancer patients

Externí odkaz: https://doaj.org/article/cf37407463bf4ba0bb61202449cb3345

Regulation of HCN2 Current by PI3K/Akt Signaling

Autor: Zhongju Lu, Hong Zhan Wang, Chris R. Gordon, Lisa M. Ballou, Richard Z. Lin, Ira S. Cohen

Publikováno v: Frontiers in Physiology, Vol 11 (2020)

It has long been known that heart rate is regulated by the autonomic nervous system. Recently, we demonstrated that the pacemaker current, If, is regulated by phosphoinositide 3-kinase (PI3K) signaling independently of the autonomic nervous system. I

Externí odkaz: https://doaj.org/article/4b0af37d918243b786b650aaacfa599c

The Risk of QTc Prolongation in Non-Diabetic and Diabetic Patients Taking Tyrosine Kinase Inhibitors (TKIs)- A Patient Safety Project at a Private Oncology Practice

Autor: Ying Luu, Imran Husain, Peng Yang, David Chu, Alan Kaell, Ira L. Cohen, Zhongju Lu, Jack Ip, Michael Lu, Chang-Kyung Kim, Richard Z. Lin

Publikováno v: Journal of Community Hospital Internal Medicine Perspectives
article-version (VoR) Version of Record
Journal of Community Hospital Internal Medicine Perspectives, Vol 11, Iss 6, Pp 799-807 (2021)

Objective: To assess the prevalence of QTc prolongation in both non-diabetic and diabetic patients on TKIs. Some TKIs have been reported to cause QTc prolongation, which is prevalent in diabetes. However, there is no Risk Evaluation and Mitigation St

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58b9d8343a98267f626b89d7d958bb77
https://doi.org/10.1080/20009666.2021.1978652

Computational optogenetics: empirically-derived voltage- and light-sensitive channelrhodopsin-2 model.

Autor: John C Williams, Jianjin Xu, Zhongju Lu, Aleksandra Klimas, Xuxin Chen, Christina M Ambrosi, Ira S Cohen, Emilia Entcheva

Publikováno v: PLoS Computational Biology, Vol 9, Iss 9, p e1003220 (2013)

Channelrhodospin-2 (ChR2), a light-sensitive ion channel, and its variants have emerged as new excitatory optogenetic tools not only in neuroscience, but also in other areas, including cardiac electrophysiology. An accurate quantitative model of ChR2

Externí odkaz: https://doaj.org/article/4e29eef920094eb69f3af22a50d86070

Regulation of heart rate and the pacemaker current by phosphoinositide 3-kinase signaling

Autor: Evgeny P. Anyukhovsky, Richard Z. Lin, Lisa M. Ballou, Zhongju Lu, Ya-Ping Jiang, Hong Zhan Wang, Michael R. Rosen, Ira S. Cohen, Junyuan Gao

Publikováno v: The Journal of General Physiology

Heart rate in physiological conditions is set by the sinoatrial node (SN), the primary cardiac pacing tissue. Phosphoinositide 3-kinase (PI3K) signaling is a major regulatory pathway in all normal cells, and its dysregulation is prominent in diabetes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74aa3c477da783cb71b6b82b1c949406
https://pubmed.ncbi.nlm.nih.gov/31431492