Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Zhonghuang, Li"'
Identification of New EGFR Inhibitors by Structure-Based Virtual Screening and Biological Evaluation
Autor:
Shuyi Wang, Xiaotian Xu, Chuxin Pan, Qian Guo, Qinlan Li, Shanhe Wan, Zhonghuang Li, Jiajie Zhang, Xiaoyun Wu
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 3, p 1887 (2024)
Epidermal growth factor receptor (EGFR) inhibitors have been used in clinical for the treatment of non-small-cell lung cancer for years. However, the emergence of drug resistance continues to be a major problem. To identify potential inhibitors, mole
Externí odkaz:
https://doaj.org/article/473171bfc23b4186bc3b8cfacaea6838
Autor:
Ying Jiang, Chunhui Huang, Yaqi Huang, Lifan Long, Guowu Wu, Fengqiu Guo, Chuan Huang, Siming Liu, Zhengguang Zhu, Shaoyu Wu, Zhonghuang Li, Jiajie Zhang, Shanhe Wan
Publikováno v:
Pharmaceutics, Vol 15, Iss 5, p 1501 (2023)
Targeting the epidermal growth factor receptor (EGFR) is one of the potential ways to treat glioblastoma (GBM). In this study, we investigate the anti-GBM tumor effects of the EGFR inhibitor SMUZ106 in both in vitro and in vivo conditions. The effect
Externí odkaz:
https://doaj.org/article/cf092b77dd624b77bb00da65f249eb02
Autor:
Yangcheng Ai, Zichao Yang, Zilong Yang, Shanhe Wan, Chunhui Huang, Chuan Huang, Mingxia Li, Zhonghuang Li, Jiajie Zhang, Tingting Zhang
Publikováno v:
Journal of Chemical Information and Modeling. 63:493-506
Publikováno v:
SSRN Electronic Journal.
Epidermal growth factor receptor (EGFR) inhibitors represent the first-line treatment of non-small-cell lung cancer (NSCLC). However, the emergence of acquired drug resistance and side effects largely encumbered their application in clinic. The emerg
Autor:
Zichao, Yang, Yangcheng, Ai, Shanhe, Wan, Zilong, Yang, Honghao, Li, Zhonghuang, Li, Chunhui, Huang, Lishun, Zhang, Mingxia, Li, Jiajie, Zhang, Tingting, Zhang
Publikováno v:
Bioorganic & Medicinal Chemistry. 74:117069
C-Abl is involved in various biological processes and plays an important role in neurodegenerative diseases, especially Parkinson's disease (PD). Previous studies have found that nilotinib shows a neuroprotective effect in cell and animal models of P
Combined 3D-QSAR and Docking Modelling Study on Indolocarbazole Series Compounds as Tie-2 Inhibitors
Publikováno v:
International Journal of Molecular Sciences, Vol 12, Iss 8, Pp 5080-5097 (2011)
Tie-2, a kind of endothelial cell tyrosine kinase receptor, is required for embryonic blood vessel development and tumor angiogenesis. Several compounds that showed potent activity toward this attractive anticancer drug target in the assay have been
Externí odkaz:
https://doaj.org/article/7bfb2288e2134c06bd103f8bd6a26d20
Autor:
Yuanxin Tian, Jianxin Pang, Xinhua Chen, Jiajie Zhang, Jiajun Luo, Ting Wu, Zean Zhao, Shan Chang, Yudong Shen, Zhonghuang Li, Shanhe Wan
Publikováno v:
Bioorganic chemistry. 117
As a promising therapeutic target for gout, hURAT1 has attracted increasing attention. In this work, we identified a novel scaffold of hURAT1 inhibitors from a personal natural product database of verified herb-treated gout. First, we constructed mor
Publikováno v:
Molecules, Vol 22, Iss 4, p 542 (2017)
RAF (Ras activating factor) kinases are important and attractive targets for cancer therapy. With the aim of discovering RAF inhibitors that bind to DFG-out inactive conformation created by the movement of Asp-Phe-Gly (DFG), we conducted structure-ba
Externí odkaz:
https://doaj.org/article/ce3bb013a34b472bbe699ad0d015dcae
The epidermal growth factor receptor (EGFR) kinase inhibitors Gefitinib, Erlotinib, Afatinib and Osimertinib have been approved for the treatments of non-small cell lung cancer patients harboring sensitive EGFR mutations, but resistance arises rapidl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d212db7fb9eb00a15b1dcace7e9726c9
Autor:
Lishun Zhang, Jiajie Zhang, Zhonghuang Li, Tingting Zhang, Xuan Xu, Shaoyu Wu, Zichao Yang, Shanhe Wan, Huiwu Zhang, Hai-Kui Yang, Yangcheng Ai
Publikováno v:
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 152
In this paper, we designed and synthesized two analog compounds M1 and T1 that have a Michael acceptor warhead. Although only slightly diversity existed in the structures of M1 and T1, their inhibitory activities against wild type epidermal growth fa