Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Zhonghong Gan"'
Autor:
Hui Liu, Alireza Baradaran-Heravi, Keith Clinch, Jennifer M. Mason, Michel Roberge, Michael Popadynec, Olga V. Zubkova, Scott A. Cameron, Phillip M. Rendle, Dennis M. Whitfield, David A. Powell, Fengyang Yan, Benjamin Alford, Zhonghong Gan, Oscar Rebollo
Publikováno v:
ACS Med Chem Lett
[Image: see text] A significant proportion of genetic disease cases arise from truncation of proteins caused by premature termination codons. In eukaryotic cells some aminoglycosides cause readthrough of premature termination codons during protein tr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9aae307b2d261f09ba6a29e8c77cb102
https://europepmc.org/articles/PMC8436412/
https://europepmc.org/articles/PMC8436412/
Autor:
Zhonghong Gan, Prabhat Arya, P. Thirupathi Reddy, Nauzer Forbes, Donald M. Leek, S. Quevillon
Publikováno v:
Journal of Combinatorial Chemistry. 8:856-871
With the goal of developing a modular approach leading to different indoline alkaloid natural-product-like tricyclic derivatives having an unsaturated lactam (see compounds 13, 14, and 16), an aminoindoline-based bicyclic scaffold 10 was obtained fro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd20f2f0371838239d365670d03f8ff6
https://doi.org/10.1021/cc0600573
https://doi.org/10.1021/cc0600573
Autor:
Donald M. Leek, Prabhat Arya, S. Quevillon, M. Parisien, Patricia Durieux, D. Laforce, L.-C. Campeau, Reni Joseph, Z.‐X. Chen, Zhonghong Gan, S. Khadem, R. Kumar, Chang-Qing Wei, Malgosia Daroszewska, Michael L. Barnes, U. Sharma, E. Sesmilo, Samuel Couve-Bonnaire, P. T. Reddy
Publikováno v:
Pure and Applied Chemistry. 77:163-178
Due to the growing interest in small molecules that could help in understanding protein–protein interactions based on signal transduction, the demand for the generation of small-molecule libraries that are inspired by bioactive natural products has
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34e763e2cf058529e8ccae2162dff4c3
https://doi.org/10.1351/pac200577010163
https://doi.org/10.1351/pac200577010163
Autor:
René Roy, Zhonghong Gan
Publikováno v:
Canadian Journal of Chemistry. 80:908-916
Clusters of O- and S-linked α-sialosides with valencies of two to four were constructed to serve as potential multivalent inhibitors towards sialoadhesins (siglecs). Thus, O- and S-prop-2-ynyl α-sialosides (3, 7), together with 4-iodophenyl sialosi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::828f6779b35f046e21d101f650d10782
https://doi.org/10.1139/v02-053
https://doi.org/10.1139/v02-053
Autor:
René Roy, Zhonghong Gan
Publikováno v:
Tetrahedron. 56:1423-1428
Olefin metathesis catalyzed by RuCl2(CHPh)(PCy3)2 (1) has been used to synthesize homodimers of O- and S-alkenyl α-sialoside derivatives. The reactions afforded reasonable to good yields under mild reaction conditions. Trans-geometrical isomers were
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0dce3332d2dfc7b121648995001996ab
https://doi.org/10.1016/s0040-4020(00)00034-x
https://doi.org/10.1016/s0040-4020(00)00034-x
Autor:
Zhonghong Gan, René Roy
Publikováno v:
Tetrahedron Letters. 41:1155-1158
Using copper(I)-catalyzed Glaser reaction and palladium-catalyzed Sonogashira reaction, divalent ‘rod-like’ thiomanno-, gluco, galacto, and lactoside clusters were prepared in high yields.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0a9697edd51756d8d5c2aabd63f5b0b4
https://doi.org/10.1016/s0040-4039(99)02285-6
https://doi.org/10.1016/s0040-4039(99)02285-6
Publikováno v:
Carbohydrate Research. 318:75-81
Glycosylation of 4-nitrophenyl 2-acetamido-6-O-tert-butyldiphenylsilyl-2-deoxy-1-thio-beta-D-gluc opyranoside with phenyl 2,3,4,6-tetra-O-benzoyl-1-thio-beta-D-galactopyranoside in the presence of NIS and TfOH as catalyst gave the lactosamine derivat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92d118a6f2fc91ba4a5de4963729a67c
https://doi.org/10.1016/s0008-6215(99)00080-4
https://doi.org/10.1016/s0008-6215(99)00080-4
Autor:
Lars T. Piehler, René Roy, Jon D. Reuter, Dujie Qin, Michael M. Hayes, Roseita Esfand, Donald A. Tomalia, Andrzej Myc, Rui Yin, Zhonghong Gan, James R. Baker
Publikováno v:
Bioconjugate Chemistry. 10:271-278
Multiple sialic acid (SA) residues conjugated to a linear polyacrylamide backbone are more effective than monomeric SA at inhibiting influenza-induced agglutination of red blood cells. However, "polymeric inhibitors" based on polyacrylamide backbones
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f55e23d29584a52da05107bf7eee7c89
https://doi.org/10.1021/bc980099n
https://doi.org/10.1021/bc980099n
Publikováno v:
Journal of Carbohydrate Chemistry. 18:755-773
An efficient methodology for regiospecific glycosylation was developed by using 6-O-tert-butyldiphenylsilyl N-acetylglucosamine derivatives 3 and 5 which bear two free hydroxyl groups as acceptors. The regiospecificity was attributed to the presence
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::04be64b73ca182232e82c0d3cfd748a2
https://doi.org/10.1080/07328309908544034
https://doi.org/10.1080/07328309908544034
Publikováno v:
Angewandte Chemie International Edition
Angewandte Chemie International Edition, Wiley-VCH Verlag, 2005, 44 (9), pp.1366-1368. ⟨10.1002/anie.200462298⟩
Angewandte Chemie International Edition, Wiley-VCH Verlag, 2005, 44 (9), pp.1366-1368. ⟨10.1002/anie.200462298⟩
International audience; A library of tricyclic derivatives, similar to indoline alkaloids, has been generated by using a stereocontrolled, conjugate hetero‐Michael approach in both the solution and the solid phase (see scheme; P=protecting group, R
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8565d8a982e7bc4d857627aa12bbe2b1
https://doi.org/10.1002/anie.200462298
https://doi.org/10.1002/anie.200462298