Zobrazeno 1 - 10
of 96
pro vyhledávání: '"Zhonghe Zhai"'
Autor:
Danying Chen, Tao Chen, Heng Zhang, Wei-Wei Yang, Sheng‐Sheng Song, Shuai Wang, Zhonghe Zhai, Yong-Kang Yang
Publikováno v:
EMBO reports. 17:1155-1168
Retinoic acid‐inducible gene I (RIG‐I) and melanoma differentiation‐associated gene 5 (MDA5) are cytoplasmic sensors crucial for recognizing different species of viral RNAs, which triggers the production of type I interferons (IFNs) and inflamm
Autor:
Danying Chen, Fei-Xiong Zhang, Hai-Wei Chen, Zhonghe Zhai, Yong-Kang Yang, Hao Xu, Meng-Tong Li, Wei Di
Publikováno v:
Journal of Virology. 87:10037-10046
Retinoic acid-inducible gene I (RIG-I) is a key sensor for recognizing nucleic acids derived from RNA viruses and triggers beta interferon (IFN-β) production. Because of its important role in antiviral innate immunity, the activity of RIG-I must be
Publikováno v:
Journal of Biological Chemistry. 286:10568-10580
Retinoic acid-inducible gene I (RIG-I) recognizes RNA virus-derived nucleic acids, which leads to the production of type I interferon (IFN) in most cell types. Tight regulation of RIG-I activity is important to prevent ultra-immune responses. In this
Publikováno v:
Nature Immunology. 10:1300-1308
MAVS is critical in innate antiviral immunity as the sole adaptor for RIG-I-like helicases. MAVS regulation is essential for the prevention of excessive harmful immune responses. Here we identify PCBP2 as a negative regulator in MAVS-mediated signali
Publikováno v:
Cellular and Molecular Life Sciences. 66:2573-2584
Toll-like receptors (TLRs) act as sensors of microbial components and elicit innate immune responses. All TLR signaling pathways activate the nuclear factor-kappaB (NF-kappaB), which controls the expression of inflammatory cytokine genes. Transformin
Autor:
Hong-Bing Shu, Zhonghe Zhai, Yang Tian, Min Zhang, Yan Zhang, Danying Chen, Ruipeng Wang, Feici Diao, Dong Gao
Publikováno v:
Cell Research. 18:1096-1104
Viral infection causes host cells to produce type I interferons (IFNs), which are critically involved in viral clearance. Previous studies have demonstrated that activation of the transcription factor interferon regulatory factor (IRF)3 is essential
Autor:
Ting Liu, Bicheng Zhang, Paul Waterman, Philippa Marrack, Yan-Yi Wang, Ai-Ping Mao, Jun Huang, Liang-Guo Xu, Hongliang Li, Zhonghe Zhai, Hong-Bing Shu, De-Pei Liu
Publikováno v:
Cell Research. 18:900-910
Here, we report the identification of GIDE, a mitochondrially located E3 ubiquitin ligase. GIDE contains a C-terminal RING finger domain, which is mostly conserved with those of the IAP family members and is required for GIDE's E3 ligase activity. Ov
Autor:
Danying Chen, Fang Chen, Yijuan Du, Zheng Zhang, Min Zhang, Gang Chen, Hong-Bing Shu, Zhonghe Zhai
Publikováno v:
Cellular Signalling. 20:666-674
Toll-like receptors are involved in host defense against invading pathogens. The two members of this superfamily, IL-1R and TLR4, activate overlapping NF-kappaB activate signaling pathway mediated by TRAF6. In this study, we identified syntenin as a
Autor:
Shu Li, Liang-Guo Xu, Min Zhang, Yan Zhang, Zhonghe Zhai, Po Tien, Ruipeng Wang, Danying Chen, Hong-Bing Shu, Yang Tian, Feici Diao, Bo Zhong
Publikováno v:
Proceedings of the National Academy of Sciences. 104:11706-11711
Viral infection leads to activation of the transcription factors interferon regulatory factor-3 and NF-κB, which collaborate to induce type I IFNs. The RNA helicase proteins RIG-I and MDA5 were recently identified as two cytoplasmic viral RNA sensor
Publikováno v:
Scientific Reports
Host cells orchestrate the production of IFN-β upon detecting invading viral pathogens. Here, we report that Ring finger protein 166 (RNF166) potentiates RNA virus-triggered IFN-β production. Overexpression of RNF166 rather than its homologous prot