Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Zhongfeng Ye"'
Autor:
Yu Zhao, Zhongfeng Ye, Donghui Song, Douglas Wich, Shuliang Gao, Jennifer Khirallah, Qiaobing Xu
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-11 (2023)
Abstract Endo-lysosomal escape is a highly inefficient process, which is a bottleneck for intracellular delivery of biologics, including proteins and nucleic acids. Herein, we demonstrate the design of a lipid-based nanoscale molecular machine, which
Externí odkaz:
https://doaj.org/article/9ad5c63e81a04d7c9b1f8f08add12d28
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 12, Iss 6, Pp 2624-2639 (2022)
Lipid nanoparticle (LNP)-based drug delivery systems have become the most clinically advanced non-viral delivery technology. LNPs can encapsulate and deliver a wide variety of bioactive agents, including the small molecule drugs, proteins and peptide
Externí odkaz:
https://doaj.org/article/0606e635f6e4441b88ed37b4fe55c5be
Autor:
Shuliang Gao, Huiwen Guan, Bloomer, Hanan, Wich, Douglas, Donghui Song, Khirallah, Jennifer, Zhongfeng Ye, Yu Zhao, Mengting Chen, Chutian Xu, Lihan Liu, Qiaobing Xu
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America; 1/9/2024, Vol. 121 Issue 2, p1-12, 60p
Autor:
Zhongfeng Ye, Bonam, Srinivasa Reddy, McKay, Lindsay G. A., Plante, Jessica A., Walker, Jordyn, Yu Zhao, Changfeng Huang, Jinjin Chen, Chutian Xu, Yamin Li, Lihan Liu, Harmon, Joseph, Shuliang Gao, Donghui Song, Zhibo Zhang, Plante, Kenneth S., Griffiths, Anthony, Jianzhu Chen, Haitao Hu, Qiaobing Xu
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America; 12/26/2023, Vol. 120 Issue 52, p1-12, 46p
Autor:
Zackery A. Ely, Nicolas Mathey-Andrews, Santiago Naranjo, Samuel I. Gould, Kim L. Mercer, Gregory A. Newby, Christina M. Cabana, William M. Rideout, Grissel Cervantes Jaramillo, Jennifer M. Khirallah, Katie Holland, Peyton B. Randolph, William A. Freed-Pastor, Jessie R. Davis, Zachary Kulstad, Peter M. K. Westcott, Lin Lin, Andrew V. Anzalone, Brendan L. Horton, Nimisha B. Pattada, Sean-Luc Shanahan, Zhongfeng Ye, Stefani Spranger, Qiaobing Xu, Francisco J. Sánchez-Rivera, David R. Liu, Tyler Jacks
Publikováno v:
Nature Biotechnology.
Autor:
Jinjin, Chen, Zhongfeng, Ye, Changfeng, Huang, Min, Qiu, Donghui, Song, Yamin, Li, Qiaobing, Xu
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 119(34)
The targeted delivery of messenger RNA (mRNA) to desired organs remains a great challenge for in vivo applications of mRNA technology. For mRNA vaccines, the targeted delivery to the lymph node (LN) is predicted to reduce side effects and increase th
Autor:
Zhongfeng Ye, Jinjin Chen, Xuewei Zhao, Yamin Li, Joseph Harmon, Changfeng Huang, Jianzhu Chen, Qiaobing Xu
Publikováno v:
ACS Biomaterials Science & Engineering. 8:722-733
Chimeric antigen receptor (CAR)-engineered adoptive cell therapy marks a revolution in cancer treatment based on the highly successful responses to CAR T cell therapy in the treatment of blood cancers. Due to the versatile structure of CARs, this tec
Publikováno v:
Journal of the American Chemical Society.
Photoresponsive inhibitor and noninhibitor systems have been developed to achieve on-demand enzyme activity control. However, inhibitors are only effective for a specific and narrow range of enzymes. Noninhibitor systems usually require mutation and
Publikováno v:
Proceedings of the National Academy of Sciences. 119
The targeted delivery of messenger RNA (mRNA) to desired organs remains a great challenge for in vivo applications of mRNA technology. For mRNA vaccines, the targeted delivery to the lymph node (LN) is predicted to reduce side effects and increase th
Autor:
Min Qiu, Yan Tang, Jinjin Chen, Rachel Muriph, Zhongfeng Ye, Changfeng Huang, Jason Evans, Elizabeth P. Henske, Qiaobing Xu
Publikováno v:
Proceedings of the National Academy of Sciences. 119
Safe and efficacious systemic delivery of messenger RNA (mRNA) to specific organs and cells in vivo remains the major challenge in the development of mRNA-based therapeutics. Targeting of systemically administered lipid nanoparticles (LNPs) coformula