Zobrazeno 1 - 10
of 63
pro vyhledávání: '"Zhongcheng Shi"'
Autor:
Chandra Sekhar Amara, Karthik Reddy Kami Reddy, Yang Yuntao, Yuen San Chan, Danthasinghe Waduge Badrajee Piyarathna, Lacey Elizabeth Dobrolecki, David J. H. Shih, Zhongcheng Shi, Jun Xu, Shixia Huang, Matthew J. Ellis, Andrea B. Apolo, Leomar Y. Ballester, Jianjun Gao, Donna E. Hansel, Yair Lotan, H. Courtney Hodges, Seth P. Lerner, Chad J. Creighton, Arun Sreekumar, W. Jim Zheng, Pavlos Msaouel, Shyam M. Kavuri, Nagireddy Putluri
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract SMARCB1 loss has long been observed in many solid tumors. However, there is a need to elucidate targetable pathways driving growth and metastasis in SMARCB1-deficient tumors. Here, we demonstrate that SMARCB1 deficiency, defined as genomic S
Externí odkaz:
https://doaj.org/article/92dacc4a9b18472087b40b7343faadf4
Autor:
Zhongcheng Shi, PhD, Yuko Mori-Akiyama, MD, Wa Du, PhD, Robert Fultz, PhD, Yanling Zhao, PhD, Wenly Ruan, MD, Susan Venable, Melinda A. Engevik, PhD, James Versalovic, MD, PhD
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 13, Iss 3, Pp 717-737 (2022)
Background & Aims: We previously showed that histamine suppressed inflammation-associated colonic tumorigenesis through histamine type 2 receptor (H2R) signaling in mice. This study aimed to precisely elucidate the downstream effects of H2R activatio
Externí odkaz:
https://doaj.org/article/dede34a6854d4efa898e633b9abcc4bd
Autor:
Melinda A. Engevik, Berkley Luck, Chonnikant Visuthranukul, Faith D. Ihekweazu, Amy C. Engevik, Zhongcheng Shi, Heather A. Danhof, Alexandra L. Chang-Graham, Anne Hall, Bradley T. Endres, Sigmund J. Haidacher, Thomas D. Horvath, Anthony M. Haag, Sridevi Devaraj, Kevin W. Garey, Robert A. Britton, Joseph M. Hyser, Noah F. Shroyer, James Versalovic
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 11, Iss 1, Pp 221-248 (2021)
Background & Aims: The human gut microbiota can regulate production of serotonin (5-hydroxytryptamine [5-HT]) from enterochromaffin cells. However, the mechanisms underlying microbial-induced serotonin signaling are not well understood. Methods: Adul
Externí odkaz:
https://doaj.org/article/104cb38cf9ef42919922904300f90cbe
Autor:
Yang Yu, Yanling Zhao, Jongmin Choi, Zhongcheng Shi, Linjie Guo, John Elizarraras, Andy Gu, Feng Cheng, Yanxin Pei, Dai Lu, Muller Fabbri, Saurabh Agarwal, Chunchao Zhang, Sung Yun Jung, Jennifer H. Foster, Jianhua Yang
Publikováno v:
Cancers, Vol 14, Iss 22, p 5534 (2022)
Neuroblastoma (NB) is a pediatric tumor of the peripheral nervous system. Approximately 80% of relapsed NB show RAS-MAPK pathway mutations that activate ERK, resulting in the promotion of cell proliferation and drug resistance. Ulixertinib, a first-i
Externí odkaz:
https://doaj.org/article/538fb8b1ff7345e7af6a491c24e7069e
Autor:
Melinda A. Engevik, Heather A. Danhof, Wenly Ruan, Amy C. Engevik, Alexandra L. Chang-Graham, Kristen A. Engevik, Zhongcheng Shi, Yanling Zhao, Colleen K. Brand, Evan S. Krystofiak, Susan Venable, Xinli Liu, Kendal D. Hirschi, Joseph M. Hyser, Jennifer K. Spinler, Robert A. Britton, James Versalovic
Publikováno v:
mBio, Vol 12, Iss 2 (2021)
ABSTRACT Multiple studies have implicated microbes in the development of inflammation, but the mechanisms remain unknown. Bacteria in the genus Fusobacterium have been identified in the intestinal mucosa of patients with digestive diseases; thus, we
Externí odkaz:
https://doaj.org/article/ebd421ea1ed24b248d975fb71e9bd169
Autor:
Melinda A. Engevik, Beatrice Herrmann, Wenly Ruan, Amy C. Engevik, Kristen A. Engevik, Faith Ihekweazu, Zhongcheng Shi, Berkley Luck, Alexandra L. Chang-Graham, Magdalena Esparza, Susan Venable, Thomas D. Horvath, Sigmund J. Haidacher, Kathleen M. Hoch, Anthony M. Haag, Deborah A. Schady, Joseph M. Hyser, Jennifer K. Spinler, James Versalovic
Publikováno v:
Gut Microbes, Vol 13, Iss 1 (2021)
Endoplasmic reticulum (ER) stress compromises the secretion of MUC2 from goblet cells and has been linked with inflammatory bowel disease (IBD). Although Bifidobacterium can beneficially modulate mucin production, little work has been done investigat
Externí odkaz:
https://doaj.org/article/b547b2a318584a06832bccfb65d0de91
Autor:
Robert Fultz, Melinda A. Engevik, Zhongcheng Shi, Anne Hall, Beatrice Herrmann, Bhanu P. Ganesh, Angela Major, Anthony Haag, Yuko Mori‐Akiyama, James Versalovic
Publikováno v:
MicrobiologyOpen, Vol 8, Iss 10, Pp n/a-n/a (2019)
Abstract The histamine H2 receptor (H2R) is a G protein‐coupled receptor that mediates cyclic AMP production, protein kinase A activation, and MAP kinase signaling. In order to explore the multifaceted effects of histamine signaling on immune cells
Externí odkaz:
https://doaj.org/article/1e029c0607754cab8356dc36865ed784
Autor:
Melinda A. Engevik, Berkley Luk, Alexandra L. Chang-Graham, Anne Hall, Beatrice Herrmann, Wenly Ruan, Bradley T. Endres, Zhongcheng Shi, Kevin W. Garey, Joseph M. Hyser, James Versalovic
Publikováno v:
mBio, Vol 10, Iss 3 (2019)
ABSTRACT Much remains unknown about how the intestinal microbiome interfaces with the protective intestinal mucus layer. Bifidobacterium species colonize the intestinal mucus layer and can modulate mucus production by goblet cells. However, select Bi
Externí odkaz:
https://doaj.org/article/9df25faecc214510a661581000847ab5
Autor:
Chunxu Gao, Angela Major, David Rendon, Monica Lugo, Vanessa Jackson, Zhongcheng Shi, Yuko Mori-Akiyama, James Versalovic
Publikováno v:
mBio, Vol 6, Iss 6 (2015)
ABSTRACT Probiotics and commensal intestinal microbes suppress mammalian cytokine production and intestinal inflammation in various experimental model systems. Limited information exists regarding potential mechanisms of probiotic-mediated immunomodu
Externí odkaz:
https://doaj.org/article/eb3b3982c86c4934b19bccfa57f04b6e
Supplementary Figures 1-5, Tables 1-2 from Activation of Toll-like Receptor 5 on Breast Cancer Cells by Flagellin Suppresses Cell Proliferation and Tumor Growth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0115bfea8cdfba9acb8f3db6d7f64cf1
https://doi.org/10.1158/0008-5472.22387679.v1
https://doi.org/10.1158/0008-5472.22387679.v1