Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Zhong Qin Liang"'
Autor:
Na Liu, Wei-Long Wu, Xiao-Rui Wan, Jing Wang, Jia-Ni Huang, Yi-Yue Jiang, Yi-Chao Sheng, Jun-Chao Wu, Zhong-Qin Liang, Zheng-Hong Qin, Yan Wang
Publikováno v:
Redox Biology, Vol 73, Iss , Pp 103176- (2024)
Excitotoxicity is a prevalent pathological event in neurodegenerative diseases. The involvement of ferroptosis in the pathogenesis of excitotoxicity remains elusive. Transcriptome analysis has revealed that cytoplasmic reduced nicotinamide adenine di
Externí odkaz:
https://doaj.org/article/3c3de55a7f404d049347076c2d826fcc
Autor:
Na Liu, Miao-Miao Lin, Si-Si Huang, Zi-Qi Liu, Jun-Chao Wu, Zhong-Qin Liang, Zheng-Hong Qin, Yan Wang
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
AimPrevious research recognizes that NADPH can produce reduced glutathione (GSH) as a coenzyme and produce ROS as a substrate of NADPH oxidase (NOX). Besides, excessive activation of glutamate receptors results in mitochondrial impairment. The study
Externí odkaz:
https://doaj.org/article/9528ce3832ae4b209258e867024e0ee7
Autor:
Xiao Shen, Zhong-qin Liang, Ying Zhu, Wen-qing Zuo, Yajie Xiong, Ya-li Liu, Fang Lin, Yi-fan Zhao
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 378:276-286
Our previous studies have shown that cathepsin L (CTSL) is involved in the ability of tumors to resist ionizing radiation (IR), but the specific mechanisms responsible for this remain unknown. We report here that mutant p53 (mut-p53) is involved in I
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3a10b2d5d385be0bf30ec3ce85f52df
https://doi.org/10.1124/jpet.121.000639
https://doi.org/10.1124/jpet.121.000639
Autor:
Zhong-Qin Liang, Xiao-Xia Wang, Yumei Wang, De-Maw Chuang, Marian DiFiglia, Thomas N. Chase, Zheng-Hong Qin
Publikováno v:
Neurobiology of Disease, Vol 20, Iss 2, Pp 562-573 (2005)
The present studies evaluated the potential contribution of Bcl-2, p53, and c-Myc to the differential vulnerability of striatal neurons to the excitotoxin quinolinic acid (QA). In normal rat striatum, Bcl-2 immunoreactivity (Bcl-2-i) was most intense
Externí odkaz:
https://doaj.org/article/f31f7c8311c0406e9e34e2f8bbcd8b71
Autor:
Hai-Dong Xu, Dan Wu, Jin-Hua Gu, Jian-Bin Ge, Jun-Chao Wu, Rong Han, Zhong-Qin Liang, Zheng-Hong Qin
Publikováno v:
PLoS ONE, Vol 8, Iss 5, p e63232 (2013)
Autophagy can be induced under nutrition stress conditions. Bcl-2 is a pro-survival protein which inhibits apoptosis and autophagy. However, the role of Bcl-2 in autophagy regulation and cell survival under nutrition deprivation has not been fully un
Externí odkaz:
https://doaj.org/article/ae68670055334b23a7ed4834a3be120f
Publikováno v:
PLoS ONE, Vol 8, Iss 9, p e75702 (2013)
The present study seeks to investigate the role of cathepsin L in glutamate receptor-induced transcription factor nuclear factor-kappa B (NF-κB) activation and excitotoxicity in rats striatal neurons. Stereotaxic administration of the N-methyl-d-asp
Externí odkaz:
https://doaj.org/article/ea34e7d3e4a2447cad541343ec31140f
Publikováno v:
Molecular & Cellular Toxicology. 8:187-193
Malignant gliomas are the most common and aggressive primary brain tumor. A major barrier to the treatment of glioma is the drug resistance. The existence of glioma stem cells may be responsible for drug resistance. Recent clinical data show that ars
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6ab0bf1041c7809bdd6118627d23ccc3
https://doi.org/10.1007/s13273-012-0023-7
https://doi.org/10.1007/s13273-012-0023-7
Publikováno v:
Chinese Journal of Cancer
Glioma stem/progenitor cells (GSPCs) are considered to be responsible for the initiation, propagation, and recurrence of gliomas. The factors determining their differentiation remain poorly defined. Accumulating evidences indicate that alterations in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ecaa1dce7fa809ef3f454da7325d7f5
http://europepmc.org/articles/PMC4012271
http://europepmc.org/articles/PMC4012271
Autor:
Zhong Qin Liang, Yan Wang, Zheng-Hong Qin, Xingding Zhang, Jun Chao Wu, Zhen Lun Gu, Rong Han
Publikováno v:
Autophagy. 4:214-226
Previous studies found that kainic acid (KA)-induced apoptosis involved the lysosomal enzyme cathepsin B, suggesting a possible mechanism of autophagy in excitotoxicity. The present study was sought to investigate activation and contribution of autop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70a1753324e21e3e703a04eaff73672c
https://doi.org/10.4161/auto.5369
https://doi.org/10.4161/auto.5369
Publikováno v:
Asian Pacific journal of cancer prevention : APJCP. 15(19)
The aim of this study was to investigate the effects of olanzapine on growth inhibition as well as autophagy in glioma cells in vitro and in vivo. The proliferation of both LN229 and T98 glioma cells, measured by MTT assay, was suppressed in a concen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d0f87d4404da3f80b00e22343a80b00
https://pubmed.ncbi.nlm.nih.gov/25338992
https://pubmed.ncbi.nlm.nih.gov/25338992