Zobrazeno 1 - 10
of 106
pro vyhledávání: '"Zhong‐Ru Xie"'
Autor:
Jian Wang, Yuxi Teng, Ruihua Zhang, Yifei Wu, Lei Lou, Yusong Zou, Michelle Li, Zhong-Ru Xie, Yajun Yan
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
SpCas9 has a NGG PAM requirement that limits its DNA target range. Here the authors present a PAM-expanded SpdCas9 variant SpdNG-LWQT to target NRN PAMs.
Externí odkaz:
https://doaj.org/article/3a51c52620b74b36aec06b2ae3c5ca95
Autor:
Yifei Wu, Scott D. Pegan, David Crich, Ellison Desrochers, Edward B. Starling, Madelyn C. Hansen, Carson Booth, Lauren Nicole Mullininx, Lei Lou, Kuan Y. Chang, Zhong-Ru Xie
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 19, Iss , Pp 5371-5380 (2021)
Although scientists around the world have put lots of effort into the development of new treatments for COVID-19 since the outbreak, no drugs except Veklury (remdesivir) have been approved by FDA. There is an urgent need to discover some alternative
Externí odkaz:
https://doaj.org/article/310baa95dfac4bc6ae63923efa9607c0
Autor:
Joseph Andrew Whitley, Sungjin Kim, Lei Lou, Chenming Ye, Omar Awad Alsaidan, Essilvo Sulejmani, Jingwen Cai, Ellison Gerona Desrochers, Zanna Beharry, Catherine Bowes Rickman, Mikael Klingeborn, Yutao Liu, Zhong‐Ru Xie, Houjian Cai
Publikováno v:
Journal of Extracellular Vesicles, Vol 11, Iss 4, Pp n/a-n/a (2022)
Abstract CRISPR/Cas9 genome editing is a very promising avenue for the treatment of a variety of genetic diseases. However, it is still very challenging to encapsulate CRISPR/Cas9 machinery for delivery. Protein N‐myristoylation is an irreversible
Externí odkaz:
https://doaj.org/article/5004da086bee4b22b97e9a63aac1f15d
Publikováno v:
Frontiers in Chemistry, Vol 8 (2020)
Speeding up the drug discovery process is of great significance. To achieve that, high-efficiency methods should be exploited. The conventional wet-bench methods hardly meet the high-speed demand due to time-consuming experiments. Conversely, in sili
Externí odkaz:
https://doaj.org/article/ce0e745e51ac4cd2933091ffa1ec985b
Publikováno v:
Informatics in Medicine Unlocked, Vol 21, Iss , Pp 100461- (2020)
The COVID-19 pandemic has caused unprecedented health and economic crisis throughout the world. However, there is no effective medication or therapeutic strategy for treatment of this disease currently. Here, to elucidate the inhibitory effects, we f
Externí odkaz:
https://doaj.org/article/b91d9ddf25bb43e8960940d8342d2c2b
Autor:
Yifei Wu, David Crich, Scott D. Pegan, Lei Lou, Madelyn C. Hansen, Carson Booth, Ellison Desrochers, Lauren Nicole Mullininx, Edward B. Starling, Kuan Y. Chang, Zhong-Ru Xie
Publikováno v:
Molecules, Vol 26, Iss 24, p 7438 (2021)
An increasing number of studies have demonstrated the antiviral nature of polyphenols, and many polyphenols have been proposed to inhibit SARS-CoV or SARS-CoV-2. Our previous study revealed the inhibitory mechanisms of polyphenols against DNA polymer
Externí odkaz:
https://doaj.org/article/e30c6cbd597d486e848a3419022341cb
Autor:
Yifei Wu, Scott D. Pegan, David Crich, Lei Lou, Lauren Nicole Mullininx, Edward B. Starling, Carson Booth, Andrew Edward Chishom, Kuan Y. Chang, Zhong-Ru Xie
Publikováno v:
International Journal of Molecular Sciences
Volume 24
Issue 5
Pages: 4397
Volume 24
Issue 5
Pages: 4397
Papain-like protease (PLpro) is critical to COVID-19 infection. Therefore, it is a significant target protein for drug development. We virtually screened a 26,193 compound library against the PLpro of SARS-CoV-2 and identified several drug candidates
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b4292d870f8055fffb83c48d408dee5
Autor:
Yifei Wu, Tze-chen Hsieh, Joseph M. Wu, Xiaoxiao Wang, Joshua S. Christopher, Amanda H. Pham, Justin David-Li Swaby, Lei Lou, Zhong-Ru Xie
Publikováno v:
Biomolecules, Vol 10, Iss 9, p 1223 (2020)
Resveratrol, the most widely studied natural phytochemical, has been shown to interact with different target proteins. Previous studies show that resveratrol binds and inhibits DNA polymerases and some other enzymes; however, the binding and function
Externí odkaz:
https://doaj.org/article/e18ac083cafd479da6d32a254e680040
Autor:
Xin Li, Kenza Mamouni, Rui Zhao, Yifei Wu, Zhong-Ru Xie, Giuseppe Sautto, Degang Liu, Nathan Bowen, Alira Danaher, Lajos Gera, Daqing Wu
Publikováno v:
Cancer Research. 83:519-519
Purpose: Despite numerous therapeutic modalities, including chemotherapy and next-generation androgen deprivation therapy, metastatic castration-resistant prostate cancer (mCRPC) remains a dreadful evolution and still bears a poor prognosis for most
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5eb80afd25362dca00724c4190c685ce
https://doi.org/10.1158/1538-7445.am2023-519
https://doi.org/10.1158/1538-7445.am2023-519
Autor:
Yifei Wu, Yajun Yan, Yusong Zou, Ruihua Zhang, Yuxi Teng, Zhong-Ru Xie, Jian Wang, Lei Lou, Michelle Li
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
Nature Communications
Nature Communications
The RNA-guided CRISPR-associated Cas9 proteins have been widely applied in programmable genome recombination, base editing or gene regulation in both prokaryotes and eukaryotes. SpCas9 from Streptococcus pyogenes is the most extensively engineered Ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::203af29f8a26c0fb1200b6b094d64e59
https://doaj.org/article/3a51c52620b74b36aec06b2ae3c5ca95
https://doaj.org/article/3a51c52620b74b36aec06b2ae3c5ca95