Targeting 7-Dehydrocholesterol Reductase Integrates Cholesterol Metabolism and IRF3 Activation to Eliminate Infection

Autor: Xiao, Jun, Li, Weiyun, Zheng, Xin, Qi, Linlin, Wang, Hui, Zhang, Chi, Wan, Xiaopeng, Zheng, Yuxiao, Zhong, Ruiyue, Zhou, Xin, Lu, Yao, Li, Zhiqi, Qiu, Ying, Liu, Chang, Zhang, Fang, Zhang, Yanbo, Xu, Xiaoyan, Yang, Zhongzhou, Chen, Hualan, Zhai, Qiwei, Wei, Bin, Wang, Hongyan

Publikováno v: In Immunity 14 January 2020 52(1):109-122

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LRCH1 deficiency enhances LAT signalosome formation and CD8 ⁺ T cell responses against tumors and pathogens.

Autor: Liu C; Cancer Center, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, 200072 Shanghai, China.; State Key Laboratory of Cell Biology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, University of Chinese Academy of Sciences, 200031 Shanghai, China., Xu X; State Key Laboratory of Cell Biology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, University of Chinese Academy of Sciences, 200031 Shanghai, China.; Laboratory of Immunology, National Eye Institute, Bethesda, MD 20892., Han L; State Key Laboratory of Cell Biology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, University of Chinese Academy of Sciences, 200031 Shanghai, China.; The Core Laboratory in Medical Center of Clinical Research, Department of Endocrinology, Shanghai Jiaotong University School of Medicine, 200011 Shanghai, China., Wan X; State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, 150001 Harbin, China., Zheng L; State Key Laboratory of Cell Biology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, University of Chinese Academy of Sciences, 200031 Shanghai, China., Li C; State Key Laboratory of Cell Biology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, University of Chinese Academy of Sciences, 200031 Shanghai, China.; Key Laboratory for Experimental Teratology of Ministry of Education, Department of Histology and Embryology, School of Basic Medical Science, Shandong University, 250012 Shandong, China., Liao Z; Department of Immuno-cell Therapy, CARsgen Therapeutics Ltd., 200231 Shanghai, China., Xiao J; State Key Laboratory of Cell Biology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, University of Chinese Academy of Sciences, 200031 Shanghai, China., Zhong R; State Key Laboratory of Cell Biology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, University of Chinese Academy of Sciences, 200031 Shanghai, China., Zheng X; State Key Laboratory of Cell Biology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, University of Chinese Academy of Sciences, 200031 Shanghai, China., Wang Q; State Key Laboratory of Cell Biology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, University of Chinese Academy of Sciences, 200031 Shanghai, China., Li Z; Department of Immuno-cell Therapy, CARsgen Therapeutics Ltd., 200231 Shanghai, China.; State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Shanghai Jiaotong University School of Medicine, 200032 Shanghai, China., Chen H; State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, 150001 Harbin, China., Wei B; Cancer Center, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, 200072 Shanghai, China; weibinwhy@shu.edu.cn hongyanwang@sibcb.ac.cn.; School of Life Sciences, Shanghai University, 200444 Shanghai, China., Wang H; State Key Laboratory of Cell Biology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, University of Chinese Academy of Sciences, 200031 Shanghai, China; weibinwhy@shu.edu.cn hongyanwang@sibcb.ac.cn.; School of Life Science, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, 310024 Hangzhou, China.

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2020 Aug 11; Vol. 117 (32), pp. 19388-19398. Date of Electronic Publication: 2020 Jul 29.