Sirt7 protects against vascular calcification via modulation of reactive oxygen species and senescence of vascular smooth muscle cells

Autor: Yu, Hongjiao, Xie, Yuchen, Lan, Lan, Ma, Siyu, Mok, Simon Wing Fai, Wong, Io Nam, Wang, Yueheng, Zhong, Guoli, Yuan, Liang, Zhao, Huan, Hu, Xiao, Macrae, Vicky E., He, Shengping, Chen, Guojun, Zhu, Dongxing

Publikováno v: In Free Radical Biology and Medicine October 2024 223:30-41

TSG101 depletion dysregulates mitochondria and PML NBs, triggering MAD2-overexpressing interphase cell death (MOID) through AIFM1-PML-DAXX pathway.

Autor: Xi Y; National Resource Center for Mutant Mice, MOE Key Laboratory of Model Animals for Disease Study, Model Animal Research Center, Medical School of Nanjing University, Nanjing, 210061, China.; Jiangsu Key Laboratory of Molecular Medicine, Medical School of Nanjing University, Nanjing, 210032, China., Xu R; National Resource Center for Mutant Mice, MOE Key Laboratory of Model Animals for Disease Study, Model Animal Research Center, Medical School of Nanjing University, Nanjing, 210061, China.; Jiangsu Key Laboratory of Molecular Medicine, Medical School of Nanjing University, Nanjing, 210032, China., Chen S; National Resource Center for Mutant Mice, MOE Key Laboratory of Model Animals for Disease Study, Model Animal Research Center, Medical School of Nanjing University, Nanjing, 210061, China.; Jiangsu Key Laboratory of Molecular Medicine, Medical School of Nanjing University, Nanjing, 210032, China., Fang J; National Resource Center for Mutant Mice, MOE Key Laboratory of Model Animals for Disease Study, Model Animal Research Center, Medical School of Nanjing University, Nanjing, 210061, China.; Jiangsu Key Laboratory of Molecular Medicine, Medical School of Nanjing University, Nanjing, 210032, China., Duan X; National Resource Center for Mutant Mice, MOE Key Laboratory of Model Animals for Disease Study, Model Animal Research Center, Medical School of Nanjing University, Nanjing, 210061, China.; Jiangsu Key Laboratory of Molecular Medicine, Medical School of Nanjing University, Nanjing, 210032, China., Zhang Y; National Resource Center for Mutant Mice, MOE Key Laboratory of Model Animals for Disease Study, Model Animal Research Center, Medical School of Nanjing University, Nanjing, 210061, China.; Jiangsu Key Laboratory of Molecular Medicine, Medical School of Nanjing University, Nanjing, 210032, China., Zhong G; National Resource Center for Mutant Mice, MOE Key Laboratory of Model Animals for Disease Study, Model Animal Research Center, Medical School of Nanjing University, Nanjing, 210061, China.; Jiangsu Key Laboratory of Molecular Medicine, Medical School of Nanjing University, Nanjing, 210032, China., He Z; National Resource Center for Mutant Mice, MOE Key Laboratory of Model Animals for Disease Study, Model Animal Research Center, Medical School of Nanjing University, Nanjing, 210061, China.; Jiangsu Key Laboratory of Molecular Medicine, Medical School of Nanjing University, Nanjing, 210032, China., Guo Y; Jiangsu Key Laboratory of Molecular Medicine, Medical School of Nanjing University, Nanjing, 210032, China., Li X; Jiangsu Key Laboratory of Molecular Medicine, Medical School of Nanjing University, Nanjing, 210032, China., Tao W; National Resource Center for Mutant Mice, MOE Key Laboratory of Model Animals for Disease Study, Model Animal Research Center, Medical School of Nanjing University, Nanjing, 210061, China.; Jiangsu Key Laboratory of Molecular Medicine, Medical School of Nanjing University, Nanjing, 210032, China., Li Y; National Resource Center for Mutant Mice, MOE Key Laboratory of Model Animals for Disease Study, Model Animal Research Center, Medical School of Nanjing University, Nanjing, 210061, China.; Jiangsu Key Laboratory of Molecular Medicine, Medical School of Nanjing University, Nanjing, 210032, China., Li Y; National Resource Center for Mutant Mice, MOE Key Laboratory of Model Animals for Disease Study, Model Animal Research Center, Medical School of Nanjing University, Nanjing, 210061, China.; Jiangsu Key Laboratory of Molecular Medicine, Medical School of Nanjing University, Nanjing, 210032, China., Fang L; Jiangsu Key Laboratory of Molecular Medicine, Medical School of Nanjing University, Nanjing, 210032, China. njfanglei@nju.edu.cn., Niikura Y; National Resource Center for Mutant Mice, MOE Key Laboratory of Model Animals for Disease Study, Model Animal Research Center, Medical School of Nanjing University, Nanjing, 210061, China. niikura@nju.edu.cn.; Jiangsu Key Laboratory of Molecular Medicine, Medical School of Nanjing University, Nanjing, 210032, China. niikura@nju.edu.cn.

Publikováno v: Cell death & disease [Cell Death Dis] 2024 Nov 17; Vol. 15 (11), pp. 838. Date of Electronic Publication: 2024 Nov 17.