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Structure-Activity Relationship Studies of Substituted 2-Phenyl-1,2,4-triazine-3,5(2 H ,4 H )-dione Analogues: Development of Potent eEF2K Degraders against Triple-Negative Breast Cancer.

Autor: Zhao X; Department of Medicinal Chemistry, Jiangsu Key Laboratory of Neuropsychiatric Diseases and College of Pharmaceutical Sciences, Soochow University, Suzhou 215123, China., Zhong C; Department of Pharmacy, The Second Xiangya Hospital, Central South University, Changsha 410011, China.; Hunan Provincial Engineering Research Centre of Translational Medicine and Innovative Drug, Changsha 410011, China., Zhu R; Department of Medicinal Chemistry, Jiangsu Key Laboratory of Neuropsychiatric Diseases and College of Pharmaceutical Sciences, Soochow University, Suzhou 215123, China., Gong R; Department of Pharmacy, The Second Xiangya Hospital, Central South University, Changsha 410011, China.; Hunan Provincial Engineering Research Centre of Translational Medicine and Innovative Drug, Changsha 410011, China., Liu B; Department of Medicinal Chemistry, Jiangsu Key Laboratory of Neuropsychiatric Diseases and College of Pharmaceutical Sciences, Soochow University, Suzhou 215123, China., He L; Department of Pharmacy, The Second Xiangya Hospital, Central South University, Changsha 410011, China.; Hunan Provincial Engineering Research Centre of Translational Medicine and Innovative Drug, Changsha 410011, China., Tian S; Department of Medicinal Chemistry, Jiangsu Key Laboratory of Neuropsychiatric Diseases and College of Pharmaceutical Sciences, Soochow University, Suzhou 215123, China.; Jiangsu Province Engineering Research Center of Precision Diagnostics and Therapeutics Development, Soochow University, Suzhou 215123, China., Jin J; Department of Medicinal Chemistry, Jiangsu Key Laboratory of Neuropsychiatric Diseases and College of Pharmaceutical Sciences, Soochow University, Suzhou 215123, China., Jiang T; Department of Pharmacy, The Second Xiangya Hospital, Central South University, Changsha 410011, China.; Hunan Provincial Engineering Research Centre of Translational Medicine and Innovative Drug, Changsha 410011, China., Chen JL; Department of Medicinal Chemistry, Jiangsu Key Laboratory of Neuropsychiatric Diseases and College of Pharmaceutical Sciences, Soochow University, Suzhou 215123, China., Wan X; Department of Pharmacy, The Second Xiangya Hospital, Central South University, Changsha 410011, China.; Hunan Provincial Engineering Research Centre of Translational Medicine and Innovative Drug, Changsha 410011, China., Liu W; Department of Medicinal Chemistry, Jiangsu Key Laboratory of Neuropsychiatric Diseases and College of Pharmaceutical Sciences, Soochow University, Suzhou 215123, China., Jiang S; Department of Pharmacy, Xiangya Hospital, Central South University, Changsha 410011, China., Deng P; Department of Medicinal Chemistry, Jiangsu Key Laboratory of Neuropsychiatric Diseases and College of Pharmaceutical Sciences, Soochow University, Suzhou 215123, China., Cheng Y; Department of Pharmacy, The Second Xiangya Hospital, Central South University, Changsha 410011, China.; Hunan Provincial Engineering Research Centre of Translational Medicine and Innovative Drug, Changsha 410011, China.; Key Laboratory of Diabetes Immunology, Central South University, Ministry of Education, Changsha 410011, China., Ye N; Department of Medicinal Chemistry, Jiangsu Key Laboratory of Neuropsychiatric Diseases and College of Pharmaceutical Sciences, Soochow University, Suzhou 215123, China.; Jiangsu Province Engineering Research Center of Precision Diagnostics and Therapeutics Development, Soochow University, Suzhou 215123, China.

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2024 Sep 12; Vol. 67 (17), pp. 15837-15861. Date of Electronic Publication: 2024 Aug 29.