Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Zhizhou Yue"'
Autor:
Han Wang, Zihan Qiu, He Liu, Amarasooriya M. D. S. Jayawardhana, Zhizhou Yue, Hala Daghlas, David J. Bowers, Bansidhar Datta, Yao-Rong Zheng
Publikováno v:
Frontiers in Chemistry, Vol 7 (2019)
A long-standing challenge in the treatment of ovarian cancer is drug resistance to standard platinum-based chemotherapy. Recently, increasing attention has been drawn to the use of self-assembled metal-organic complexes as novel therapeutics for canc
Externí odkaz:
https://doaj.org/article/c066d7bc865e4d5993f2d5c3bfffe3b1
Autor:
Zhizhou Yue, Payel Datta, Yao-Rong Zheng, Han Wang, Manabu Kurokawa, Morgan Stilgenbauer, Scott Bang, Travis Beach, Haihua Xiao, David J. Bowers
Publikováno v:
Dalton Transactions. 49:8107-8113
Cisplatin is a platinum-based chemotherapeutic agent widely used in the treatment of various solid tumors. However, a major challenge in the use of cisplatin and in the development of cisplatin derivatives, namely Pt(iv) prodrugs, is their premature
Autor:
R. Jeffrey Neitz, Zhizhou Yue, Neal Jeffrey Green, Shan Li, Stacie L. Bulfer, Tsui-Fen Chou, Raffaele Colombo, James C. Burnett, Matthew G. LaPorte, Peter Wipf, Donna M. Huryn, Michelle R. Arkin, Celeste Alverez, William J. Moore
Publikováno v:
ACS medicinal chemistry letters, vol 9, iss 11
ACS Medicinal Chemistry Letters
ACS Medicinal Chemistry Letters
Optimization of the side-chain of a phenyl indole scaffold identified from a high-throughput screening campaign for inhibitors of the AAA+ ATPase p97 is reported. The addition of an N-alkyl piperazine led to high potency of this series in a biochemic
Autor:
Thomas D. Bannister, Yen Ting Chen, Zhizhou Yue, Michael D. Cameron, Laura M. Bohn, Kimberly M. Lovell, Nicole M. Kennedy, Nicolette C. Ross, Cullen L. Schmid
Publikováno v:
Journal of Medicinal Chemistry. 61:8895-8907
While mu opioid receptor (MOR) agonists are especially effective as broad-spectrum pain relievers, it has been exceptionally difficult to achieve a clear separation of analgesia from many problematic side effects. Recently, many groups have sought MO
Autor:
David J. Bowers, Payel Datta, Haihua Xiao, Zhizhou Yue, Frederick Nielsen, Amarasooriya M. D. S. Jayawardhana, Morgan Stilgenbauer, Yao-Rong Zheng, Michael S Gray
Publikováno v:
Chemical communications (Cambridge, England). 55(43)
We developed a spermine-conjugated lipophilic Pt(iv) prodrug that is able to reduce the cancer stem cell population in ovarian cancer. The therapeutic effect is attributed to the hydrophobic tail and cationic spermine head group, the combination of w
Autor:
Shankar Mandal, Zhizhou Yue, Toshikazu Bando, Hanbin Mao, Yusuke Kawamoto, Kaori Hashiya, Mohammad Akter Hossain, Yunxi Cui, Shankar Pandey, Mohammed Enamul Hoque, Hiroshi Sugiyama
Publikováno v:
Nucleic Acids Research
To modulate biological functions, G-quadruplexes in genome are often non-specifically targeted by small molecules. Here, specificity is increased by targeting both G-quadruplex and its flanking duplex DNA in a naturally occurring dsDNA–ssDNA telome
Autor:
Hala Daghlas, Han Wang, He Liu, Zhizhou Yue, Bansidhar Datta, Yao-Rong Zheng, Amarasooriya M. D. S. Jayawardhana, Zihan Qiu, David J. Bowers
Publikováno v:
Frontiers in Chemistry
Frontiers in Chemistry, Vol 7 (2019)
Frontiers in Chemistry, Vol 7 (2019)
A long-standing challenge in the treatment of ovarian cancer is drug resistance to standard platinum-based chemotherapy. Recently, increasing attentions hasve been drawn to the use of self-assembled metal-organic complexes as novel therapeutics for c
Autor:
Mahinda Gangoda, Yi Qin, Zhizhou Yue, David J. Bowers, Yao-Rong Zheng, Han Wang, Lin Xu, Yiming Li, Hai-Bo Yang, Xiaopeng Li
Publikováno v:
Chemical communications (Cambridge, England). 54(7)
This article presents a new strategy to engage coordination-driven self-assembly for platinum drug delivery. The self-assembled supramolecular hexagon is conjugated with three equivalents of Pt(IV) prodrugs and displays a superior therapeutic index c
Autor:
Jacob T. Shelley, Zhizhou Yue, Frederick Nielsen, Morgan Stilgenbauer, Yao-Rong Zheng, Han Wang, Min Gao, David J. Bowers
Publikováno v:
Dalton transactions (Cambridge, England : 2003). 47(3)
We present a novel design to use metal-organic cages (MOCs) to encapsulate Pt-based anticancer agents for delivery. A fluorescein-conjugated Pt(iv) prodrug of cisplatin is developed for its encapsulation in a cationic MOC via host-guest interactions,
Autor:
Cullen L. Schmid, Nicole M. Kennedy, Zhizhou Yue, Nicolette C. Ross, Jenny Morgenweck, Laura M. Bohn, Michael D. Cameron, Thomas D. Bannister, Kimberly M. Lovell
Biased agonism has been proposed as a means to separate desirable and adverse drug responses downstream of G protein-coupled receptor (GPCR) targets. Herein, we describe structural features of a series of mu-opioid-receptor (MOR)-selective agonists t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c1c7a7a145c8479f68b54ef405c9490
https://europepmc.org/articles/PMC5731250/
https://europepmc.org/articles/PMC5731250/