Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Zhizhen Lu"'
Publikováno v:
PLoS ONE, Vol 11, Iss 2, p e0149155 (2016)
Cardiac hypertrophy is a key pathological process of many cardiac diseases. However, early detection of cardiac hypertrophy is difficult by the currently used non-invasive method and new approaches are in urgent need for efficient diagnosis of cardia
Externí odkaz:
https://doaj.org/article/9375bc61ca9d46eeb712b73ee1cac39c
Autor:
Lingfeng ZHU1, Zhizhen LU2 lvzhizhenl992@163.com, Haijie YU1, Haifen YING1, Zheming LI1, Huashan FAN3
Publikováno v:
Medicinal Plant. Apr2024, Vol. 15 Issue 2, p84-90. 7p.
Autor:
Youyi Zhang, Yue Feng, Ai-Hua Zhang, Xiangbo An, Yao Song, Cong-Cong Zhang, Jing Shen, Jing-Jing Wang, Hao Li, Jianshu Zhang, Wei Gao, Jie Du, Jimin Wu, Haiyi Yu, Han Xiao, Xinyu Wang, Ming Xu, Zhizhen Lu, Zijian Li, Xiangning Deng
Publikováno v:
European Heart Journal
Aims Rapid over-activation of β-adrenergic receptor (β-AR) upon stress leads to cardiac inflammation, a prevailing factor that underlies heart injury. However, mechanisms by which acute β-AR stimulation induce cardiac inflammation still remain unk
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eacfae1a3e1f186a8ee7e3eca2913f62
https://doi.org/10.1093/eurheartj/ehx261
https://doi.org/10.1093/eurheartj/ehx261
Autor:
Han Xiao, Dan Li, Jianshu Zhang, Qiang Shen, Youyi Zhang, Ruifei Chen, Yao Song, Jimin Wu, Yenan Feng, Zhizhen Lu, Hao Li
Publikováno v:
British Journal of Pharmacology. 175:1217-1229
Background and Purpose Metformin, a small molecule antihyperglycaemic agent, is well-known as an AMP-activated protein kinase (AMPK) activator and protects against cardiac fibrosis. However, the underlying mechanisms remain elusive. Transforming grow
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::af72aa6ebe0dee5f7a4c60a243cd4984
https://doi.org/10.1111/bph.13753
https://doi.org/10.1111/bph.13753
Publikováno v:
Clinical and Experimental Pharmacology and Physiology. 41:58-66
1. Chronic injection with the β-adrenoceptor (β-AR) agonist isoproterenol (ISO) has been commonly used as an animal model of β-AR-induced cardiac remodelling and heart failure. This ISO-treated model usually exhibits significantly decreased consci
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa9c9f9e3bb252e98062a828e04c8e3a
https://doi.org/10.1111/1440-1681.12176
https://doi.org/10.1111/1440-1681.12176
Autor:
Jianli Liu, Zhizhen Lu, Han Xiao, Zhonghe Xu, Mingliang Zhang, Youyi Zhang, Jianshu Zhang, Yenan Feng, Xiaohong Fang, Jing Shen, Jimin Wu, Jingyuan Li, Ruifei Chen
Publikováno v:
Scientific Reports
Metformin is a widely used first-line antidiabetic drug that has been shown to protect against a variety of specific diseases in addition to diabetes, including cardiovascular disorders, polycystic ovary syndrome and cancer. However, the precise mech
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dfcdf4a24fe215875399fd27ffdceb7b
Publikováno v:
British Journal of Pharmacology. 166:676-688
BACKGROUND AND PURPOSE IL-6 plays crucial roles in cardiac hypertrophy, cardiac fibrosis and heart failure. Activation of β-adrenoceptors induced IL-6 production in neonatal mouse cardiac fibroblasts (NMCFs) through a G(s) /adenylate cyclase/cAMP/p3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::24e186cfa11b1d32e67b737066187d74
https://doi.org/10.1111/j.1476-5381.2011.01785.x
https://doi.org/10.1111/j.1476-5381.2011.01785.x
Autor:
Zijian Li, Chao Chen, Zhizhen Lu, Youyi Zhang, Yan Li, Hui Zhang, Wenqiang Liao, Yao Song, Xiaowei Ma
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 301:H1941-H1951
Li Y, Zhang H, Liao W, Song Y, Ma X, Chen C, Lu Z, Li Z, Zhang Y. α1-Adrenergic receptor (α1-AR) is a crucial mediator of cardiac hypertrophy. Although numerous intracellular pathways have been implicated in α1-AR-induced hypertrophy, its precise
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5dde4885e804482bf0d7164dc1808694
https://doi.org/10.1152/ajpheart.00338.2011
https://doi.org/10.1152/ajpheart.00338.2011
Autor:
Fei Liu, Da Liu, Zhizhen Lu, Youyi Zhang, Lei Qin, Wangxi Luo, Yuliang Zhang, Chunyang Xiong, Li Xu, Kangmin He, Xiaohong Fang
Publikováno v:
ACS Nano. 4:3015-3022
In this work, we reported that the quantum dot (QD) nanoparticles could be actively transported in the membrane nanotubes between cardiac myocytes. Single particle imaging and tracking of QDs revealed that most QDs moved in a bidirectional mode along
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fce803aedb086974ca633da794ef2045
https://doi.org/10.1021/nn1002198
https://doi.org/10.1021/nn1002198
Autor:
Wei Feng, Ming Xu, Yi Zhu, Youyi Zhang, Zhizhen Lu, Han Xiao, Qiang Shen, Xiaowei Ma, Yongnan Fu
Publikováno v:
Cardiovascular Research. 87:504-513
Aims The mechanism of the cardioprotective action of metformin is incompletely understood. We determined the role of metformin in cardiac fibrosis and investigated the mechanism. Methods and results Ten-week-old male mice (C57BL/6) were subjected to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::587de85621ef5fddffb792eef22e4189
https://doi.org/10.1093/cvr/cvq066
https://doi.org/10.1093/cvr/cvq066