Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Zhizeng Sun"'
Autor:
Zhizeng Sun, Timothy Palzkill
Publikováno v:
mBio, Vol 12, Iss 6 (2021)
ABSTRACT Colistin (polymyxin E) and polymyxin B have been used as last-resort agents for treating infections caused by multidrug-resistant Gram-negative bacteria. However, their efficacy has been challenged by the emergence of the mobile colistin res
Externí odkaz:
https://doaj.org/article/e61867662dbd4c8aa81807caa3fdb7bb
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
The NDM-1 β-lactamase confers resistance to most β-lactam antibiotics. By functional analysis of residues required for hydrolysis, Sun et al. reveal stringent sequence constraints for carbapenems, suggesting that specific combinations of NDM-1 inhi
Externí odkaz:
https://doaj.org/article/8c2aae0dbe0a437bb3b03635d51701e9
Publikováno v:
PLoS ONE, Vol 9, Iss 5, p e97121 (2014)
Lantibiotics are ribosomally-synthesized and posttranslationally modified peptides with potent antimicrobial activities. Discovery of novel lantibiotics has been greatly accelerated with the soaring release of genomic information of microorganisms. A
Externí odkaz:
https://doaj.org/article/3d29bd4e230243e09af9a1d5f264ab44
Autor:
Zhizeng Sun1, Hanfeng Lin1, Liya Hu1, Neetu, Neetu1, Sankaran, Banumathi2, Jin Wang1, Prasad, B. V. Venkataram1, Palzkill, Timothy1 timothyp@bcm.edu
Publikováno v:
Journal of Biological Chemistry. Jan2024, Vol. 300 Issue 1, p1-16. 16p.
Evaluation of Tebipenem Hydrolysis by β-Lactamases Prevalent in Complicated Urinary Tract Infections
Autor:
Zhizeng Sun, Lynn Su, Nicole Cotroneo, Ian Critchley, Michael Pucci, Akash Jain, Timothy Palzkill
Publikováno v:
Antimicrob Agents Chemother
Tebipenem pivoxil is the first orally available carbapenem antibiotic and has been approved in Japan for treating ear, nose, and throat and respiratory infections in pediatric patients. Its active moiety, tebipenem, has shown potent antimicrobial act
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::532a701cc17bec75ba583ff6f4f918a7
https://doi.org/10.1128/aac.02396-21
https://doi.org/10.1128/aac.02396-21
Autor:
Timothy Palzkill, Zhizeng Sun
Publikováno v:
mBio
mBio, Vol 12, Iss 6 (2021)
mBio, Vol 12, Iss 6 (2021)
Colistin (polymyxin E) and polymyxin B have been used as last-resort agents for treating infections caused by multidrug-resistant Gram-negative bacteria. However, their efficacy has been challenged by the emergence of the mobile colistin resistance g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b004d04cf0da7d2e2fa3e9b7ea1f027d
https://pubmed.ncbi.nlm.nih.gov/34781730
https://pubmed.ncbi.nlm.nih.gov/34781730
Autor:
Sara I. Gomez-Villegas, Vance G. Fowler, Rafael Rios, Jinnethe Reyes, Cesar A. Arias, Lina P Carvajal, Lorena Diaz, An Dinh, William R. Miller, Sandra Rincon, Esteban C. Nannini, Karen Ordóñez, Claudia Pedroza, Timothy Palzkill, Aura M Echeverri, Barbara E. Murray, Zhizeng Sun
Publikováno v:
J Clin Microbiol
The cefazolin inoculum effect (CzIE) has been associated with therapeutic failures and mortality in invasive methicillin-susceptible Staphylococcus aureus (MSSA) infections. A diagnostic test to detect the CzIE is not currently available. We develope
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05a66370b28e6f17a80e4702f4c80da5
https://pubmed.ncbi.nlm.nih.gov/33536292
https://pubmed.ncbi.nlm.nih.gov/33536292
Autor:
Zhizeng Sun, Andrew S. Waller, Samantha L. Kubiak, Matthew Ojeda Saavedra, Adeline R. Porter, Frank R. DeLeo, Timothy Palzkill, Leslie Jenkins, Luchang Zhu, Concepcion C. Cantu, Randall J. Olsen, Stephen B. Beres, James M. Musser
Publikováno v:
JCI Insight
Streptococcus pyogenes (group A streptococcus; GAS) causes 600 million cases of pharyngitis annually worldwide. There is no licensed human GAS vaccine despite a century of research. Although the human oropharynx is the primary site of GAS infection,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06fa098f2ed16ead04a25dd7a6677796
https://doi.org/10.1172/jci.insight.137686
https://doi.org/10.1172/jci.insight.137686
Autor:
Ayesha, Khan, Truc T, Tran, Rafael, Rios, Blake, Hanson, William C, Shropshire, Zhizeng, Sun, Lorena, Diaz, An Q, Dinh, Audrey, Wanger, Luis, Ostrosky-Zeichner, Timothy, Palzkill, Cesar A, Arias, William R, Miller
Publikováno v:
Open Forum Infectious Diseases
Background Treatment of serious infections due to multidrug-resistant (MDR) Pseudomonas aeruginosa remains a challenge, despite the introduction of novel therapeutics. In this study, we report 2 extensively drug-resistant clinical isolates of sequenc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::576f3e1692023d0f51a0818457bc8106
https://pubmed.ncbi.nlm.nih.gov/31281867
https://pubmed.ncbi.nlm.nih.gov/31281867
Autor:
William R. Miller, Blake Hanson, An Q Dinh, Truc T. Tran, Lorena Diaz, Rafael Rios, William C Shropshire, Audrey Wanger, Zhizeng Sun, Timothy Palzkill, Cesar A. Arias, Ayesha Khan, Luis Ostrosky-Zeichner
Two ST309Pseudomonas aeruginosaclinical isolates resistant to carbapenems and newer β-lactam/β-lactamase inhibitor combinations were found to harbor the extended spectrum beta-lactamases GES 19 and 26 genetically clustered in tandem. The combinatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69c160d1041398e1e7680662507ef3a2
https://doi.org/10.1101/535302
https://doi.org/10.1101/535302
