Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Zhize Ye"'
Autor:
Jie Chen, Yingying Hu, Jinyu Hu, Zhize Ye, Qianmeng Lin, Jian-ping Cai, Guo-xin Hu, Ren-ai Xu
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 180, Iss , Pp 117511- (2024)
The aim of this study was to investigate the catalytic activity of 26 Cytochrome P450 3A4 (CYP3A4) variants and drug interactions on imatinib metabolism in recombinant insect microsomes. This study was designed with an appropriate incubation system a
Externí odkaz:
https://doaj.org/article/3cef741ee9d0453fa4742ed7da321f06
Autor:
Zhize Ye, Hailun Xia, Jinyu Hu, Ya-nan Liu, Anzhou Wang, Jian-ping Cai, Guo-xin Hu, Ren-ai Xu
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 175, Iss , Pp 116421- (2024)
Tofacitinib can effectively improve the clinical symptoms of rheumatoid arthritis (RA) patients. In this current study, a recombinant human CYP2C19 and CYP3A4 system was operated to study the effects of recombinant variants on tofacitinib metabolism.
Externí odkaz:
https://doaj.org/article/e521898341db4c25ac01509310f911d0
Publikováno v:
PeerJ, Vol 11, p e16601 (2023)
This study aimed to investigate the interactions between icotinib/apatinib and oxycodone in rats and to unveil the underlying mechanism. An ultra-performance liquid chromatography–tandem mass spectrometry (UPLC-MS/MS) method was developed and valid
Externí odkaz:
https://doaj.org/article/0cb7cba3db2541049f3ef965d5f99d45
Publikováno v:
Iranian Journal of Basic Medical Sciences, Vol 25, Iss 5, Pp 659-663 (2022)
Objective(s): This study aims to evaluate the catalytic activities of 31 CYP2C19 alleles and their effects on the metabolism of tapentadol in vitro. Materials and Methods: Insect microsomes expressing the CYP2C19 alleles were incubated with 50–1250
Externí odkaz:
https://doaj.org/article/1d071226d96f4fcfad5bf473dc120495
Autor:
Zhize Ye, Bingbing Chen, Nanyong Gao, Qihui Kong, Xiaoqin Hu, Zhongqiu Lu, Jianchang Qian, Guoxin Hu, Jianping Cai, Bin Wu
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
This study aimed 1) to investigate the influence of CYP2D6 variants on the catalyzing of fluvoxamine, and 2) to study the interaction between fluvoxamine and apatinib. An enzymatic reaction system was setup and the kinetic profile of CYP2D6 in metabo
Externí odkaz:
https://doaj.org/article/f2d5609d984b470db4d45a747477102c
The effect of Resveratrol on the pharmacokinetic profile of tofacitinib and the underlying mechanism
Publikováno v:
Chemico-Biological Interactions. 374:110398
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a3345603ccb6fff93beacdf6546035ae
https://doi.org/10.1016/j.cbi.2023.110398
https://doi.org/10.1016/j.cbi.2023.110398
Autor:
Mingming Han, Xiaodan Zhang, Zhize Ye, Jing Wang, Qihui Kong, Xiaoqin Hu, Jianchang Qian, Jianping Cai, Guoxin Hu
Publikováno v:
Chemical research in toxicology. 35(2)
We aim to study the effects of CYP2D6 variants and drug-drug interaction on the metabolism of dacomitinib. CYP2D6 variants were incubated with 25-1000 μM dacomitinib for 40 min at 37 °C, and the reaction was terminated by cooling to -80 °C immedia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::055de62a022c401f677c0fb1537aa0e6
https://pubmed.ncbi.nlm.nih.gov/34936353
https://pubmed.ncbi.nlm.nih.gov/34936353
Publikováno v:
Chemico-Biological Interactions. 366:110123
This study investigated into the effect of CYP3A4 genetic polymorphism on istradefylline metabolism. Moreover, the potential drug-drug interaction with istradefylline was determined as well as underlied mechanism.In vitro, enzymatic reaction was perf
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::454e5fc92e3c42b6c6ddecf24cdc9fb7
https://doi.org/10.1016/j.cbi.2022.110123
https://doi.org/10.1016/j.cbi.2022.110123
Publikováno v:
Chemico-Biological Interactions. 364:110044
Cancer patients experience pain during medical treatment. Therefore, anticancer drugs and painkillers are often prescribed together. This study aims to determine the interaction between anlotinib and oxycodone and reveal the underlying mechanism.UPLC
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08dcde908e54fc65ee1cc23271ebf899
https://doi.org/10.1016/j.cbi.2022.110044
https://doi.org/10.1016/j.cbi.2022.110044
Autor:
Jian-Ping Cai, Ren-ai Xu, Daoxing Chen, Guo-Xin Hu, Mingming Han, Zhize Ye, Jian-Chang Qian, Saili Xie
Publikováno v:
Chemico-biological interactions. 345
Aim We aimed (i) to study the effects of genetic polymorphism of cytochrome P450 3A4 (CYP3A4) and drug interactions on acalabrutinib (ACA) metabolism and (ii) to investigate the mechanisms underlying the effects of CYP3A4 variants on the differential
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f819154a07e375e6d0388a2d4e5f67c
https://pubmed.ncbi.nlm.nih.gov/34153224
https://pubmed.ncbi.nlm.nih.gov/34153224