Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Zhiyun Wen"'
Autor:
Scott A. Hollingsworth, Cameron L. Noland, Karin Vroom, Anasuya Saha, Miranda Sam, Qinshan Gao, Haihong Zhou, David U. Grandy, Sujata Singh, Zhiyun Wen, Christopher Warren, Xiaohong Shirley Ma, Daniel Malashock, Jennifer Galli, Gwenny Go, Michael Eddins, Todd Mayhood, Karthik Sathiyamoorthy, Arthur Fridman, Fahimeh Raoufi, Yacob Gomez-Llorente, Andrea Patridge, Yinyan Tang, Shi-Juan Chen, Marc Bailly, Chengjie Ji, Laura J. Kingsley, Alan C. Cheng, Bernhard H. Geierstanger, Daniel M. Gorman, Lan Zhang, Kalyan Pande
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-15 (2023)
Abstract Coronaviruses have been the causative agent of three epidemics and pandemics in the past two decades, including the ongoing COVID-19 pandemic. A broadly-neutralizing coronavirus therapeutic is desirable not only to prevent and treat COVID-19
Externí odkaz:
https://doaj.org/article/a9d7ab42a9cb4a6cb05bac47eef92301
Autor:
Xiao Xiao, Arthur Fridman, Lu Zhang, Pavlo Pristatsky, Eberhard Durr, Michael Minnier, Aimin Tang, Kara S. Cox, Zhiyun Wen, Renee Moore, Dongrui Tian, Jennifer D. Galli, Scott Cosmi, Michael J. Eddins, Nicole L. Sullivan, Xiaodong Yan, Andrew J. Bett, Hua-Poo Su, Kalpit A. Vora, Zhifeng Chen, Lan Zhang
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
Here, Xiao et al. isolate a large panel of antibodies against human metapneumovirus fusion protein from human B cells, and characterize their epitopes, neutralization activities, and antigen binding specificity, providing a useful framework for under
Externí odkaz:
https://doaj.org/article/39a413c0e00f4ee69f63888b87fa5809
Autor:
Aimin Tang, Zhifeng Chen, Kara S. Cox, Hua-Poo Su, Cheryl Callahan, Arthur Fridman, Lan Zhang, Sangita B. Patel, Pedro J. Cejas, Ryan Swoyer, Sinoeun Touch, Michael P. Citron, Dhanasekaran Govindarajan, Bin Luo, Michael Eddins, John C. Reid, Stephen M. Soisson, Jennifer Galli, Dai Wang, Zhiyun Wen, Gwendolyn J. Heidecker, Danilo R. Casimiro, Daniel J. DiStefano, Kalpit A. Vora
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Respiratory syncytial virus (RSV) is a leading cause of infant hospitalization. Here, the authors isolate a human monoclonal antibody that binds to a highly conserved epitope on the RSV fusion protein, neutralizes RSV A and B subtypes equipotently an
Externí odkaz:
https://doaj.org/article/353ee58e3241465cbd5aae22b7984ad3
Autor:
Hualin Li, Cheryl Callahan, Michael Citron, Zhiyun Wen, Sinoeun Touch, Morgan A Monslow, Kara S Cox, Daniel J DiStefano, Kalpit A Vora, Andrew Bett, Amy Espeseth
Publikováno v:
PLoS ONE, Vol 12, Iss 11, p e0187642 (2017)
Respiratory syncytial virus (RSV) is a leading cause of serious lower respiratory tract disease in young children and older adults throughout the world. Prevention of severe RSV disease through active immunization is optimal but no RSV vaccine has be
Externí odkaz:
https://doaj.org/article/e018d3e0e3ee41dbb4b9118e502bda6f
Autor:
Xiao Xiao1,2,3, Zhiyun Wen1, Qing Chen4, Shipman, Jennifer M.4, Kostas, James4, Reid, John C.4, Warren, Christopher1, Aimin Tang1, Bin Luo5, O'Donnell, Gregory5, Fridman, Arthur6, Zhifeng Chen1, Vora, Kalpit A.1, Lan Zhang1, Hua-Poo Su4, Eddins, Michael J.4 michael.eddins@merck.com
Publikováno v:
Journal of Virology. Dec2023, Vol. 97 Issue 12, p1-19. 19p.
Publikováno v:
J Virol
Respiratory syncytial virus (RSV) is a serious human respiratory pathogen, but no RSV vaccine has been licensed. Many vaccine candidates are focused on the viral F protein since the F protein is more conserved than the viral G protein across RSV stra
Respiratory syncytial virus (RSV) is a serious human respiratory pathogen, but no RSV vaccine has been licensed. Many of the vaccine candidates are focused on the viral F protein. However, it is the G protein that binds the likely receptor, CX3CR1, i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::efd5125e79a6dddaf4eebbac57f69c8a
https://doi.org/10.1101/2022.09.12.507712
https://doi.org/10.1101/2022.09.12.507712
Autor:
Xiao Xiao, Arthur Fridman, Lu Zhang, Pavlo Pristatsky, Eberhard Durr, Michael Minnier, Aimin Tang, Kara S. Cox, Zhiyun Wen, Renee Moore, Dongrui Tian, Jennifer D. Galli, Scott Cosmi, Michael J. Eddins, Nicole L. Sullivan, Xiaodong Yan, Andrew J. Bett, Hua-Poo Su, Kalpit A. Vora, Zhifeng Chen, Lan Zhang
Publikováno v:
Nature communications. 13(1)
Human metapneumovirus (hMPV) belongs to thePneumoviridaefamily and is closely related to respiratory syncytial virus (RSV). The surface fusion (F) glycoprotein mediates viral fusion and is the primary target of neutralizing antibodies against hMPV. H
Autor:
Zhiyun Wen, Zhifeng Chen, Nicole L Sullivan, Kara S. Cox, Xiao Xiao, Deeptak Verma, Aimin Tang, Kerim Babaoglu, Andrew J. Bett, Lan Zhang, Jennifer D. Galli, Michael Minnier, Kalpit A. Vora, Cheryl Callahan, Deborah D. Nahas, Scott Cosmi, Hua Su
Publikováno v:
mAbs
Respiratory syncytial virus (RSV) is a leading cause of lower respiratory tract infection in young children and older adults. Currently, no licensed vaccine is available, and therapeutic options are limited. The primary target of neutralizing antibod
Autor:
Michael P. Citron, Zhiyun Wen, Nickita Mehta, Galit Alter, Amy S. Espeseth, Daniel J. DiStefano, Jishnu Das, Sinoeun Touch, Cheryl Callahan, Jeffrey R. Sachs, Tomer Zohar, Paloma Cejas, Andrew J. Bett, Anush Devadhasan, Douglas A. Lauffenburger, Wiktor Karpinski
Publikováno v:
SSRN Electronic Journal.
Respiratory syncytial virus (RSV) infection is a major cause of severe respiratory illness in both young infants and the elderly. While antibodies represent key correlates of protection, the antibody mechanisms remain poorly understood. Emerging data