Zobrazeno 1 - 10
of 67
pro vyhledávání: '"Zhiyun Peng"'
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 38, Iss 1, Pp 361-375 (2023)
Urease is a kind of nickel-dependent metalloenzyme, which exists in the biological world widely, and can catalyse the hydrolysis of urea into ammonia and carbon dioxide to provide a nitrogen source for organisms. Urease has important uses in agricult
Externí odkaz:
https://doaj.org/article/43062acfeab646e08f5272c9329229d4
Publikováno v:
Food Chemistry: X, Vol 21, Iss , Pp 101128- (2024)
Thirteen kojic acid-coumarin derivatives were synthesized using the principle of molecular hybridization, and their structures were characterized by 1H NMR, 13C NMR, and HRMS. In vitro enzyme inhibition experiments showed that all newly synthesized d
Externí odkaz:
https://doaj.org/article/8272b1e262ff4c21a3c602f89083fde7
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-11 (2023)
Abstract RNA N6-methladenosine (m6A) regulators are required for a variety of biological processes, including immune responses, and increasing evidence indicates that their dysregulation is closely associated with many diseases. However, the potentia
Externí odkaz:
https://doaj.org/article/967757c68f37445697f358f71c8870c9
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 37, Iss 1, Pp 2530-2539 (2022)
A series of litseaone B analogues 4a∼4p were synthesised and antitumor activities of all compounds were screened. These compounds were designed by introducing different substituents on the B ring. Among these synthesised compounds, it was proved th
Externí odkaz:
https://doaj.org/article/dc74d280d4c24f3f97031f213a7b1caf
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 37, Iss 1, Pp 9-38 (2022)
Microtubules play an important role in the process of cell mitosis and can form a spindle in the mitotic prophase of the cell, which can pull chromosomes to the ends of the cell and then divide into two daughter cells to complete the process of mitos
Externí odkaz:
https://doaj.org/article/08287130af0f4ec2b92995f19f0aacc9
Publikováno v:
Current Research in Food Science, Vol 6, Iss , Pp 100421- (2023)
Kojic acid-aromatic aldehydes 6a-6m were synthesized and screened for their anti-tyrosinase activities. These compounds showed potently anti-tyrosinase activity with IC50 values in the range of 5.32 ± 0.23 to 77.89 ± 3.36 μM compared with kojic ac
Externí odkaz:
https://doaj.org/article/0a508f9860fc4b01ba635f4afac57065
Publikováno v:
Arabian Journal of Chemistry, Vol 15, Iss 11, Pp 104301- (2022)
A series of natural product (2-phenyethyl)chromone analogues (3–34) were designed, synthesized, and screened for their α-glucosidase inhibitory activity. The results indicated that some of the synthesized derivatives displayed inhibitory activitie
Externí odkaz:
https://doaj.org/article/f67ebeba459f498dac79374e6e0dbc12
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 36, Iss 1, Pp 1401-1409 (2021)
A new series of sulphonamide derivatives bearing naphthalene moiety were synthesised and evaluated for their antiproliferative and tubulin polymerisation inhibitory activities. These new compounds were evaluated for their in vitro antiproliferative a
Externí odkaz:
https://doaj.org/article/59f53c8f6e5346aa93cc1341911d9d88
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 36, Iss 1, Pp 1693-1701 (2021)
A novel series of thiazole-naphthalene derivatives as tubulin polymerisation inhibitors were designed, synthesised, and evaluated for the anti-proliferative activities. The majority of the tested compounds exhibited moderate to potent antiproliferati
Externí odkaz:
https://doaj.org/article/1415ec6a95e6439ab5fbcf59127aa560
Publikováno v:
Arabian Journal of Chemistry, Vol 13, Iss 6, Pp 5765-5775 (2020)
In this study, a novel series of isoxazole-naphthalene derivatives as tubulin polymerization inhibitors were designed, synthesized and evaluated for their anti-proliferative activities against human breast cancer cell line MCF-7. Most of the synthesi
Externí odkaz:
https://doaj.org/article/b8a0398aad4d4aec824c4af114aa0289